期刊
MOLECULAR SYSTEMS BIOLOGY
卷 18, 期 4, 页码 -出版社
WILEY
DOI: 10.15252/msb.202110822
关键词
active matter; enhanced diffusion; Gibbs energy; metabolism; regulation
资金
- Netherlands Ministry of Education, Culture, and Science (OCW) [024.003.019]
- Dutch Research Council (NWO) [NWA.1292.19.170]
- European Commission within the Marie Skodowska-Curie Innovative Training Network ALERT [713482]
- Marie Curie Actions (MSCA) [713482] Funding Source: Marie Curie Actions (MSCA)
Based on recent findings, this Perspective proposes a new mechanism to explain how metabolic activity can globally regulate biomolecular processes in a cell. The increased intracellular motion caused by catalysis-induced enzyme movement may compromise biomolecular functions, thus establishing a feedback mechanism on metabolic activity. While awaiting experimental validation, this proposed explanation offers an intriguing perspective of how metabolic activity can affect biomolecular functions and may inspire new research.
Based on recent findings indicating that metabolism might be governed by a limit on the rate at which cells can dissipate Gibbs energy, in this Perspective, we propose a new mechanism of how metabolic activity could globally regulate biomolecular processes in a cell. Specifically, we postulate that Gibbs energy released in metabolic reactions is used to perform work, allowing enzymes to self-propel or to break free from supramolecular structures. This catalysis-induced enzyme movement will result in increased intracellular motion, which in turn can compromise biomolecular functions. Once the increased intracellular motion has a detrimental effect on regulatory mechanisms, this will establish a feedback mechanism on metabolic activity, and result in the observed thermodynamic limit. While this proposed explanation for the identified upper rate limit on cellular Gibbs energy dissipation rate awaits experimental validation, it offers an intriguing perspective of how metabolic activity can globally affect biomolecular functions and will hopefully spark new research.
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