4.6 Article

An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Food Science & Technology

Oxalate-rich foods

Roswitha SIENER et al.

Summary: Plants from the Fabaceae, Convolvulaceae, and Malvaceae families have high concentrations of oxalate, which can contribute to the risk of hyperoxaluria and calcium oxalate stone formation.

FOOD SCIENCE AND TECHNOLOGY (2021)

Article Biology

Development of a mechanistic model to predict synthetic biotic activity in healthy volunteers and patients with phenylketonuria

Mark R. Charbonneau et al.

Summary: The research team developed a mathematical model to predict the consumption of Phe by SYNB1618 in the gastrointestinal tract and the lowering of plasma Phe levels in PKU patients.

COMMUNICATIONS BIOLOGY (2021)

Article Transplantation

Subsequent urinary stone events are predicted by the magnitude of urinary oxalate excretion in enteric hyperoxaluria

Matthew R. D'Costa et al.

Summary: This study investigated the relationship between urinary oxalate excretion and kidney stone events in patients with enteric hyperoxaluria, finding that higher UOx levels were associated with an increased risk of kidney stones, suggesting that strategies to reduce UOx may be beneficial in this patient group.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2021)

Article Multidisciplinary Sciences

Improvement of a synthetic live bacterial therapeutic for phenylketonuria with biosensor-enabled enzyme engineering

Kristin J. Adolfsen et al.

Summary: In this study, a more potent EcN-based PKU strain was developed through the optimization of whole cell PAL activity, showcasing approximately two-fold increase in in vivo PAL activity compared to the previous strain. The biosensor-based ultra-high-throughput screening approach utilized in this study could potentially lead to improved in vivo performance for PKU treatment in the future.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip

M. Tyler Nelson et al.

Summary: Engineered bacteria, or synthetic biotics, utilize synthetic biology tools for therapeutic purposes and require translational testing to predict their function in the human body. Gut-on-a-chip microfluidics technology allows for characterization of strain function within a simulated human gastrointestinal tract, providing a framework to predict the function of candidate strains in vivo.

NATURE COMMUNICATIONS (2021)

Article Biology

Microbial genetic and transcriptional contributions to oxalate degradation by the gut microbiota in health and disease

Menghan Liu et al.

Summary: The human microbiota primarily uses type II oxalate degradation pathways, with the oxalate autotroph Oxalobacter formigenes dominating this function. Patients with inflammatory bowel disease show elevated enteric oxalate levels and reduced microbiota ODP expression, potentially contributing to disrupted oxalate homeostasis. Colonization of mice with O. formigenes leads to significant reduction in host fecal and urine oxalate levels, supporting the importance of the microbiome in host oxalate homeostasis.
Article Endocrinology & Metabolism

Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study

Marja K. Puurunen et al.

Summary: The engineered E. coli strain SYNB1618 shows potential for the treatment of PKU, as it was safe and well tolerated in a phase 1/2a clinical trial with both healthy volunteers and PKU patients. The study demonstrated dose-responsive increases in strain-specific Phe metabolites in plasma and urine, supporting the proof of concept for using engineered bacteria in the treatment of rare metabolic disorders.

NATURE METABOLISM (2021)

Article Multidisciplinary Sciences

Developing a new class of engineered live bacterial therapeutics to treat human diseases

Mark R. Charbonneau et al.

NATURE COMMUNICATIONS (2020)

Article Urology & Nephrology

Risk of chronic kidney disease in patients with kidney stones-a nationwide cohort study

Tzung-Fang Chuang et al.

BMC NEPHROLOGY (2020)

Article Multidisciplinary Sciences

Receptor-targeted engineered probiotics mitigate lethal Listeria infection

Rishi Drolia et al.

NATURE COMMUNICATIONS (2020)

Article Biotechnology & Applied Microbiology

Evaluation of Oxalobacter formigenes DSM 4420 biodegradation activity for high oxalate media content: An in vitro model

Dina Karamad et al.

BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY (2019)

Review Physiology

Dietary oxalate and kidney stone formation

Tanecia Mitchell et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2019)

Article Biotechnology & Applied Microbiology

Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria

Vincent M. Isabella et al.

NATURE BIOTECHNOLOGY (2018)

Article Medicine, Research & Experimental

Translational Development of Microbiome-Based Therapeutics: Kinetics of E-coli Nissle and Engineered Strains in Humans and Nonhuman Primates

Caroline Kurtz et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2018)

Article Biotechnology & Applied Microbiology

Engineered bacteria can function in the mammalian gut long-term as live diagnostics of inflammation

David T. Riglar et al.

NATURE BIOTECHNOLOGY (2017)

Review Food Science & Technology

Engineered Probiotics: Applications and Biological Containment

Babasola Sola-Oladokun et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 8 (2017)

Review Transplantation

Enteric hyperoxaluria: an important cause of end-stage kidney disease

Lama Nazzal et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2016)

Article Multidisciplinary Sciences

The outer mucus layer hosts a distinct intestinal microbial niche

Hai Li et al.

NATURE COMMUNICATIONS (2015)

Article Urology & Nephrology

Oxalobacter formigenes: Opening the door to probiotic therapy for the treatment of hyperoxaluria

Ankush Jairath et al.

SCANDINAVIAN JOURNAL OF UROLOGY (2015)

Review Endocrinology & Metabolism

Gastrointestinal changes after bariatric surgery

I. Quercia et al.

DIABETES & METABOLISM (2014)

Article Biochemistry & Molecular Biology

An oxalyl-CoA synthetase is important for oxalate metabolism in Saccharomyces cerevisiae

Justin Foster et al.

FEBS LETTERS (2014)

Article Urology & Nephrology

Oxalate Content of Food: A Tangled Web

Kyrollis Attalla et al.

UROLOGY (2014)

Article Pharmacology & Pharmacy

Model-Based Drug Development: A Rational Approach to Efficiently Accelerate Drug Development

P. A. Milligan et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2013)

Article Biochemistry & Molecular Biology

Translational Regulation of Gene Expression by an Anaerobically Induced Small Non-coding RNA in Escherichia coli

Anders Boysen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Biochemistry & Molecular Biology

Reprogramming of anaerobic metabolism by the FnrS small RNA

Sylvain Durand et al.

MOLECULAR MICROBIOLOGY (2010)

Article Multidisciplinary Sciences

A microbial symbiosis factor prevents intestinal inflammatory disease

Sarkis K. Mazmanian et al.

NATURE (2008)

Article Urology & Nephrology

Hyperoxaluria in kidney stone formers treated with modern bariatric surgery

John R. Asplin et al.

JOURNAL OF UROLOGY (2007)

Article Multidisciplinary Sciences

An obesity-associated gut microbiome with increased capacity for energy harvest

Peter J. Turnbaugh et al.

NATURE (2006)

Review Microbiology

Oxalobacter formigenes and its role in oxalate metabolism in the human gut

CS Stewart et al.

FEMS MICROBIOLOGY LETTERS (2004)

Article Physiology

Measurement of meal-stimulated gastric acid secretion by in vivo gastric autotitration

JD Gardner et al.

JOURNAL OF APPLIED PHYSIOLOGY (2002)

Article Urology & Nephrology

Contribution of dietary oxalate to urinary oxalate excretion

RP Holmes et al.

KIDNEY INTERNATIONAL (2001)

Article Multidisciplinary Sciences

One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products

KA Datsenko et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Urology & Nephrology

Estimation of the oxalate content of foods and daily oxalate intake

RP Holmes et al.

KIDNEY INTERNATIONAL (2000)