期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 66, 期 10, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202100669
关键词
AMPK; calcium; CaMKII; diabetes; Garcinia cambogia; glucose uptake
资金
- National Research Foundation of Korea (NRF) - Korean government [2019R1C1C1010698]
- BK21 FOUR Program by Chungnam National University
- National Research Foundation of Korea [2019R1C1C1010698] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study investigates the therapeutic effects and underlying mechanisms of Garcinia cambogia on glucose homeostasis in obesity-induced diabetes. The results show that Garcinia cambogia increases glucose uptake in muscle cells, activates signaling pathways, and regulates intracellular Ca2+ levels to facilitate glucose uptake. In a diabetes mouse model, Garcinia cambogia administration significantly lowers blood glucose levels.
Scope Garcinia cambogia (G. cambogia) is known to have antiobesity effects. In this study, the therapeutic effects of G. cambogia on glucose homeostasis in obesity-induced diabetes are explored and the underlying mechanisms are investigated. Methods and results C2C12 myotubes are treated with G. cambogia; glucose uptake, intracellular Ca2+ levels, and related alterations in signaling pathways are examined. High-fat diet (HFD)-fed mice are administered G. cambogia for 8 weeks; oral glucose tolerance is evaluated, and the regulation of identified targets of signaling pathways in quadriceps skeletal muscle are examined in vivo. G. cambogia increases glucose uptake in C2C12 myotubes and induces the upregulation of AMPK, ACC, and p38 MAPK phosphorylation. Notably, G. cambogia markedly elevates both intracellular Ca2+ levels, activating CaMKII, a Ca2+-sensing protein, and TBC1D4-mediated GLUT4 translocation, to facilitate glucose uptake. Furthermore, high-glucose-induced inhibition of glucose uptake and signal transduction is reverted by G. cambogia. In an HFD-induced diabetes mouse model, G. cambogia administration results in significant blood glucose-lowering effects, which are attributed to the regulation of targets that have been identified in vitro, in quadricep skeletal muscle. Conclusion These findings provide new insights into the mechanism by which G. cambogia regulates glucose homeostasis in obesity-induced diabetes.
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