期刊
MOLECULAR NEUROBIOLOGY
卷 59, 期 8, 页码 4718-4729出版社
SPRINGER
DOI: 10.1007/s12035-021-02710-5
关键词
Artesunate; Neural stem/progenitor cells; White matter injury; Stroke; FOXO3a/p27(kip1) axis
资金
- Military Medicine Preresearch Project of Army Medical University [2018XYY11]
- National Natural Science Foundation of China [81901267]
- Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0458]
- Youth Natural Science Foundation of Xinjiang [2022D01C346]
This study demonstrates that treatment with artesunate promotes neurogenesis and proliferation of endogenous neural stem/progenitor cells (NSPCs), leading to functional recovery after stroke through rescuing ischemia/reperfusion damage and alleviating white matter injury.
Promoting neurogenesis and proliferation of endogenous neural stem/progenitor cells (NSPCs) is considered a promising strategy for neurorehabilitation after stroke. Our previous study revealed that a moderate dose of artesunate (ART, 150 mg/ kg) could enhance functional recovery in middle cerebral artery occlusion (MCAO) mice. This study aimed to investigate the effects of ART treatment on neurogenesis and proliferation of NSPCs using a rodent MCAO model. MRI results indicated that the ischemic brain volume of MCAO mice was reduced by ART treatment. The results of diffusion tensor imaging, electron microscopic, and immunofluorescence of Tuj-1 also revealed that ischemia-induced white matter lesion was alleviated by ART treatment. After ischemia/reperfusion, the proportion of Brdu + endogenous NSPCs in the ipsilateral subventricular zone and peri-infarct cortex was increased by ART treatment. Furthermore, the neuro-restorative effects of ART were abolished by the overexpression of FOXO3a. These findings suggested that ART could rescue ischemia/reperfusion damage and alleviate white matter injury, subsequently contributing to post-stroke functional recovery by promoting neurogenesis and proliferation of endogenous NSPCs via the FOX03a/p27(Kip1) pathway.
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