期刊
MOLECULAR MEDICINE REPORTS
卷 25, 期 6, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2022.12730
关键词
curcumin; hydrogen peroxide; pyroptosis; atherosclerosis; endothelial cell
Curcumin alleviates H2O2-induced endothelial cell damage by inhibiting pyroptosis and reducing endothelin-1 expression.
Endothelial cell (EC) dysfunction is one of the initiating factors of atherosclerosis. EC dysfunction is primarily caused by oxidative damage and inflammation. As a classic non-specific antioxidant and anti-inflammatory drug, curcumin has been widely used in studies of lipid metabolism disorders. However, whether curcumin is able to alleviate H2O2-induced EC damage and its related mechanisms has remained to be elucidated. The present study confirmed the protective effects of curcumin on human umbilical vein endothelial cells (HUVECs). A HUVEC injury model was established using H2O2 and the optimal concentrations and time of curcumin to achieve therapeutic effects were explored. Curcumin was observed to inhibit H2O2-induced pyroptosis by inhibiting the activation of NOD-, LRR- and pyrin domain-containing protein 3. In addition, curcumin improved HUVEC function by restoring alpha v beta 3 and reducing endothelin-1 expression. In conclusion, the results of the present study revealed the mechanism through which curcumin inhibits pyroptosis and indicated that curcumin may have a potential utility in treating diseases of EC dysfunction.
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