期刊
MOLECULAR DIVERSITY
卷 26, 期 5, 页码 2813-2823出版社
SPRINGER
DOI: 10.1007/s11030-022-10401-z
关键词
Imidazole; Oxazole; N-(4,6-Dimethylpyrimidin-2-yl)cyanamide; Regiospecificity; Eco-friendly reaction; Intramolecular cyclization
类别
资金
- Taif University, Taif, Saudi Arabia [TURSP-2020/111]
An eco-friendly, low-cost and high-yielding synthetic route towards imidazoles and oxazoles has been developed. The desired compounds were synthesized efficiently using water as a green solvent under specific conditions.
Eco-friendly, low-cost and high-yielding synthetic route toward imidazoles and oxazoles has been developed. 1-(4,6-Dimethylpyrimidin-2-yl)-2-(alkylamino)-1,5-dihydro-4H-imidazol-4-one 3a-c have been synthesized via regiospecific reaction of ethyl 2-(N-(4,6-dimethylpyrimidin-2-yl)cyanamide)acetate 1 with primary aliphatic amines in water as green solvent. While, the reaction between 4,6-dimethylpyrimidin-2-yl(2-oxo-2-phenylethyl)cyanamide 2 and primary aliphatic amines using water and/or iso-propanol as green solvents afforded 3-(4,6-dimethylpyrimidin-2-yl)-5-phenyl-1,3-oxazole-2(3H)-imine 6 and 1-(4,6-dimethylpyrimidin-2-yl)-N-alkyl-4-phenyl-1H-imidazol-2-amine 7a-d, respectively.
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