4.8 Article

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Virology

SARS-CoV-2 viroporin encoded by ORF3a triggers the NLRP3 inflammatory pathway

Huanzhou Xu et al.

Summary: The study reveals that the ORF3a viroporin of SARS-CoV-2 activates the NLRP3 inflammasome, leading to heightened inflammatory response in severe COVID-19 cases. The activation of the inflammasome involves multiple molecular and cellular pathways, providing potential targets for intervention.

VIROLOGY (2022)

Article Immunology

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

Tamara S. Rodrigues et al.

Summary: The active NLRP3 inflammasome in response to SARS-CoV-2 infection is associated with disease severity in COVID-19 patients, with higher levels of IL-18 and Casp1p20 correlating with poor clinical outcomes. These findings suggest that inflammasomes may serve as markers of disease severity and potential therapeutic targets for COVID-19.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Multidisciplinary Sciences

NINJ1 mediates plasma membrane rupture during lytic cell death

Nobuhiko Kayagaki et al.

Summary: Plasma membrane rupture is a cataclysmic event in lytic cell death, releasing damage-associated molecular patterns to propagate the inflammatory response. NINJ1 protein plays an essential role in inducing PMR, with Ninj1-deficient macrophages showing impaired release of intracellular proteins and distinctive ballooned morphology. This study overturns the long-held belief that cell death-related PMR is a passive event, highlighting the active role of NINJ1 in mediating PMR.

NATURE (2021)

Article Immunology

Untuned antiviral immunity in COVID-19 revealed by temporal type I/III interferon patterns and flu comparison

Ioanna-Evdokia Galani et al.

Summary: Andreakos and colleagues conducted a study comparing patients with COVID-19 and influenza, finding that COVID-19 patients exhibited a dysregulated interferon response with diminished and delayed interferon production compared to flu patients. In COVID-19 patients, pro-inflammatory cytokines were produced before interferons and persisted longer, leading to worsened clinical outcomes.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Human NLRP1 is a sensor for double-stranded RNA

Stefan Bauernfried et al.

Summary: Inflammasomes play a crucial role as intracellular sensors in pathogen infection and cellular perturbation. Human NLRP1 has been identified as a direct sensor for dsRNA, triggering activation during RNA virus infection. The NLRP1 complex binds dsRNA through its leucine-rich repeat domain, leading to activation through adenosine triphosphatase activity in its NACHT domain.

SCIENCE (2021)

Article Biology

Diverse viral proteases activate the NLRP1 inflammasome

Brian Tsu et al.

Summary: The NLRP1 inflammasome can be activated by proteases from various picornaviruses within a rapidly evolving region of the protein, leading to host-specific and virus-specific activation. This suggests that host mimicry of viral polyprotein cleavage sites can be an evolutionary strategy to trigger a strong inflammatory response.
Editorial Material Critical Care Medicine

The right place for IL-1 inhibition in COVID-19

Giulio Cavalli et al.

LANCET RESPIRATORY MEDICINE (2021)

Review Biochemistry & Molecular Biology

COVID-19 and the human innate immune system

Joachim L. Schultze et al.

Summary: The introduction of SARS-CoV-2 into the human population has led to a significant medical and economic crisis. Innate immunity plays a central role in combating the novel virus, with variability in its components contributing to the diverse disease courses observed for COVID-19. Further research into the pathophysiological mechanisms of innate immunity is crucial for the development of diagnostic markers and therapeutic strategies targeting COVID-19.
Article Virology

SARS-CoV-2 Triggers an MDA-5-Dependent Interferon Response Which Is Unable To Control Replication in Lung Epithelial Cells

Antoine Rebendenne et al.

Summary: The study found that in lung cells, despite producing high levels of IFNs in response to SARS-CoV-2 infection, the IFN response was unable to control viral replication, contrary to what was observed in intestinal epithelial cells. The ambiguous interplay between viral replication and the timing of IFN responses needs to be further understood for guiding future therapeutic interventions.

JOURNAL OF VIROLOGY (2021)

Review Biochemistry & Molecular Biology

Cell entry by SARS-CoV-2

Ruchao Peng et al.

Summary: SARS-CoV-2 enters host cells by interacting with the ACE2 receptor, leading to fusion between viral and cellular membranes, with involvement of auxiliary receptors and cofactors. Understanding the molecular events during viral entry is crucial for developing vaccines and therapeutics.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Article Virology

Interfering with SARS-CoV-2: are interferons friends or foes in COVID-19?

Ivan Zanoni

Summary: Type I and type III interferons are potent antiviral cytokines essential in controlling SARS-CoV-2 infection, but the virus can hinder their production and action. Understanding the properties of these interferon families is crucial for designing efficient therapeutic interventions against COVID-19.

CURRENT OPINION IN VIROLOGY (2021)

Article Immunology

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

Megan H. Orzalli et al.

Summary: During viral infection, inhibition of protein synthesis triggers pyroptosis in human keratinocytes, leading to the release of inflammatory cytokines. MCL-1 and BCL-xL act as sensors of translation shutdown, contributing to antiviral defense by inhibiting virus replication.

IMMUNITY (2021)

Letter Critical Care Medicine

Autoantibodies against type I interferons are associated with multi-organ failure in COVID-19 patients

Rutger Koning et al.

INTENSIVE CARE MEDICINE (2021)

Article Immunology

Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1

Paul Bastard et al.

Summary: Patients with biallelic loss-of-function variants of AIRE, suffering from APS-1, produce autoantibodies that neutralize most type I interferons, leading to a significantly increased risk of life-threatening COVID-19 pneumonia. Research has shown that in APS-1 patients with these neutralizing autoantibodies, 86% developed COVID-19 pneumonia.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Virology

Inhibitors of Coronavirus 3CL Proteases Protect Cells from Protease-Mediated Cytotoxicity

Samuel J. Resnick et al.

Summary: The study developed a simplified cell-based assay for identifying chemical inhibitors of a wide range of coronavirus 3CL proteases, which can be widely used in laboratories. The assay, without the need for live virus, is suitable for high-throughput screening and has identified broad-spectrum inhibitors.

JOURNAL OF VIROLOGY (2021)

Article Multidisciplinary Sciences

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

L. Robert Hollingsworth et al.

Summary: NLRP1 is an inflammasome sensor that mediates caspase-1 activation, and its function is regulated by DPP8/DPP9, with VbP disrupting the NLRP1-DPP9 interaction to accelerate inflammasome activation.

NATURE (2021)

Article Cell Biology

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

Bowen Zhou et al.

Summary: Gasdermin E (GSDME) functions as an independent conduit for interleukin-1b (IL-1b) release in cellular inflammasome activation, regardless of its cell death ability. Our study reveals that both NLRP3 and NLRP1 inflammasomes depend on both gasdermins for IL-1b processing and release, apart from their ability to induce cell lysis.

CELL REPORTS (2021)

Article Biology

Co-regulation and function of FOXM1/RHNO1 bidirectional genes in cancer

Carter J. Barger et al.

Summary: FOXM1 and RHNO1 are co-amplified and co-expressed in high-grade serous carcinoma, and their bidirectional promoter may serve as a potential therapeutic target for ovarian and other cancers. Their oncogenic properties in HGSC cells highlight the significance of targeting the FOXM1/RHNO1 gene pair in cancer therapy.
Article Biochemistry & Molecular Biology

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

Justin M. Hansen et al.

Summary: GSDMB is targeted and destroyed by the IpaH7.8 effector protein secreted by Shigella flexneri, protecting the bacterium from natural killer cells. Unlike other gasdermin family members, GSDMB exhibits direct microbiocidal activity by recognizing phospholipids found on Gram-negative bacterial membranes.
Article Microbiology

Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection

Giovanni Luchetti et al.

Summary: The study reveals the mechanism by which IpaH7.8 from Shigella ubiquitinates human GSDMD and targets it for proteasomal degradation, contributing to the bacterium's impact on humans rather than mice.

CELL HOST & MICROBE (2021)

Article Cell Biology

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

Monique G. P. van der Wijst et al.

Summary: Autoantibodies against type I interferons have been identified in some patients with critical COVID-19, with higher prevalence in severe cases. The longitudinal dynamics and functional effects of these antibodies on circulating leukocytes remain unclear.

SCIENCE TRANSLATIONAL MEDICINE (2021)

Article Immunology

Autoantibodies neutralizing type I IFNs are present in ∼4% of uninfected individuals over 70 years old and account for ∼20% of COVID-19 deaths

Paul Bastard et al.

Summary: Autoantibodies neutralizing interferons are present in a significant percentage of critical COVID-19 patients, especially in older individuals, and their prevalence increases with age.

SCIENCE IMMUNOLOGY (2021)

Article Immunology

X-linked recessive TLR7 deficiency in ∼1% of men under 60 years old with life-threatening COVID-19

Takaki Asano et al.

Summary: A study revealed that rare X-linked TLR7 variants were found in 16 unrelated male individuals with critical COVID-19 pneumonia out of a cohort of 1202 male patients. No such variants were detected in 331 asymptomatic or mildly infected male individuals.

SCIENCE IMMUNOLOGY (2021)

Article Immunology

The first 12 months of COVID-19: a timeline of immunological insights

Thiago Carvalho et al.

Summary: The timeline of major scientific discoveries during the first year of the COVID-19 pandemic highlights the collaborative efforts that led to rapid progress in understanding the immune response to SARS-CoV-2. It showcases the unprecedented convergence of research efforts on COVID-19 and identifies gaps in knowledge for future investigations.

NATURE REVIEWS IMMUNOLOGY (2021)

Article Infectious Diseases

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

Victor M. Corman et al.

EUROSURVEILLANCE (2020)

Review Immunology

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

Achille Broggi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Microbiology

An Infectious cDNA Clone of SARS-CoV-2

Xuping Xie et al.

CELL HOST & MICROBE (2020)

Article Medicine, General & Internal

Severe Covid-19

David A. Berlin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Review Immunology

Inflammasomes and Pyroptosis as Therapeutic Targets for COVID-19

Jeremy K. Y. Yap et al.

JOURNAL OF IMMUNOLOGY (2020)

Article Infectious Diseases

A minimal common outcome measure set for COVID-19 clinical research

J. C. Marshall et al.

LANCET INFECTIOUS DISEASES (2020)

Article Multidisciplinary Sciences

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Carolina Lucas et al.

NATURE (2020)

Article Multidisciplinary Sciences

Early IL-1 receptor blockade in severe inflammatory respiratory failure complicating COVID-19

Raphael Cauchois et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia

Kim S. Robinson et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Qian Zhang et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Paul Bastard et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response

Elif Eren et al.

EMBO REPORTS (2020)

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

N-terminal degradation activates the NLRP1B inflammasome

Ashley J. Chui et al.

SCIENCE (2019)

Editorial Material Biochemistry & Molecular Biology

Degradation of proteins with N-terminal glycine

Mohamed Eldeeb et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2019)

Review Immunology

The NLRP1 inflammasome: new mechanistic insights and unresolved mysteries

Patrick S. Mitchell et al.

CURRENT OPINION IN IMMUNOLOGY (2019)

Article Biochemistry & Molecular Biology

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

Darren C. Johnson et al.

NATURE MEDICINE (2018)

Article Biochemistry & Molecular Biology

Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding

Franklin L. Zhong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

Marian C. Okondo et al.

CELL CHEMICAL BIOLOGY (2018)

Article Virology

Enterovirus 71 Inhibits Pyroptosis through Cleavage of Gasdermin D

Xiaobo Lei et al.

JOURNAL OF VIROLOGY (2017)

Article Biochemistry & Molecular Biology

Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages

Cornelius Y. Taabazuing et al.

CELL CHEMICAL BIOLOGY (2017)

Article Multidisciplinary Sciences

A Modular Assembly Platform for Rapid Generation of DNA Constructs

Elliot H. Akama-Garren et al.

SCIENTIFIC REPORTS (2016)

Review Immunology

Inflammasomes: mechanism of assembly, regulation and signalling

Petr Broz et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Multidisciplinary Sciences

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Nobuhiko Kayagaki et al.

NATURE (2015)

Article Multidisciplinary Sciences

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi et al.

NATURE (2015)

Article Biochemistry & Molecular Biology

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

Alvin Lu et al.

Article Immunology

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

Bernardo S. Franklin et al.

NATURE IMMUNOLOGY (2014)

Letter Biochemical Research Methods

Improved vectors and genome-wide libraries for CRISPR screening

Neville E. Sanjana et al.

NATURE METHODS (2014)