期刊
MOLECULAR BIOLOGY REPORTS
卷 49, 期 7, 页码 6633-6645出版社
SPRINGER
DOI: 10.1007/s11033-022-07246-y
关键词
Esophageal squamous cell carcinoma; PTEN; Radiotherapy; Chemotherapy; PD-L1
资金
- Hebei Clinical Research Center for Radiation Oncology
- Oncology Department of Hebei Medical University
This review summarizes the roles of tumor suppressor gene PTEN and programmed cell death protein PD-1 in promoting ESCC, including their involvement in cell proliferation, invasion, migration, and resistance to treatment. The expression of PD-L1 and PTEN is also associated with ESCC progression and patient prognosis.
Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer in China and developing countries. The purpose of this review is to summarize the roles of inactivation of the tumor suppressor gene, phosphatase and tensin homolog (PTEN), and activation of the programmed cell death protein 1 (PD-1) upon binding to its ligand (PD-L1) in the promotion of ESCC. Studies of ESCC performed in vitro and in vivo indicated that PTEN and PD-L1 function in the regulation of cell proliferation, invasion, and migration; the epithelial-mesenchymal transition; resistance to chemotherapy and radiotherapy; and the PI3K/AKT signaling pathway. Certain genetic variants of PTEN are related to susceptibility to ESCC, and PTEN and PD-L1 also function in ESCC progression and affect the prognosis of patients with ESCC. There is also evidence that the expression of PD-L1 and PTEN are associated with the progression of certain other cancers. Future studies should further examine the relationship of PD-L1 and PTEN and their possible interactions in ESCC.
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