Role of non-coding RNAs in response of breast cancer to radiation therapy

Breast cancer ranks as the first common cancer with a high incidence rate and mortality among women. Radiation therapy is the main therapeutic method for breast cancer patients. However, radiation resistance of tumor cells can reduce the efficacy of treatment and lead to recurrence and mortality in patients. Non-coding RNA (ncRNAs) refers to a group of small RNA molecules that are not translated into protein, while they have the ability to modulate the translation of target mRNA. Several studies have reported the altered expression of ncRNAs in response to radiation in breast cancer. NcRNAs have been found to influence on radiation response of breast cancer by regulating various mechanisms, including DNA damage response, cell cycle regulation, cell death, inflammatory response, cancer stem cell and EGFR related pathways. This paper aimed to provide a summary of current findings on ncRNAs dysregulation after irradiation. We also present the function and mechanism of ncRNAs in modulating radiosensitivity or radioresistance of breast cancer cells.

Automated summary

Breast cancer is the most common cancer among women, and radiation therapy is the main treatment method. However, radiation resistance of tumor cells can affect the efficacy of treatment and lead to recurrence and mortality. Non-coding RNA (ncRNAs) play an important role in the response of breast cancer to radiation, influencing the radiosensitivity of breast cancer cells through the regulation of various mechanisms.