期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 548, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2022.111617
关键词
Fibroblast growth factor 19; Bile acid metabolism; Carbohydrate metabolism; Lipid metabolism; Protein synthesis; Farnesoid x receptor
资金
- USDA, Agricultural Research Service [3092-51000-060-01]
- National Institutes of Health NIDDK [R01-DK094616, T32-DK007664, K01-DK129408]
This review summarizes the current literature on the protein FGF19, its target receptors, and the biological pathways they target through unique signaling cascades.
Since the discovery of fibroblast growth factor (FGF)-19 over 20 years ago, our understanding of the peptide and its role in human biology has moved forward significantly. A member of a superfamily of paracrine growth factors regulating embryonic development, FGF19 is unique in that it is a dietary-responsive endocrine hormone linked with bile acid homeostasis, glucose and lipid metabolism, energy expenditure, and protein synthesis during the fed to fasted state. FGF19 achieves this through targeting multiple tissues and signaling pathways within those tissues. The diverse functional capabilities of FGF19 is due to the unique structural characteristics of the protein and its receptor binding in various cell types. This review will cover the current literature on the protein FGF19, its target receptors, and the biological pathways they target through unique signaling cascades.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据