期刊
MODERN RHEUMATOLOGY
卷 33, 期 2, 页码 330-337出版社
OXFORD UNIV PRESS
DOI: 10.1093/mr/roac026
关键词
systemic sclerosis; stem cell transplantation; long-term outcomes; meta-analysis
类别
Hematopoietic stem cell transplantation (HSCT) is an effective treatment for systemic sclerosis (SSc), although it is associated with higher treatment-related deaths. However, patients who undergo HSCT have a high survival rate post-transplant.
Objectives We aimed to evaluate the efficacy and safety of hematopoietic stem cell transplantation (HSCT) in patients with systemic sclerosis (SSc). Methods A systematic literature review and meta-analysis were carried out. We compared survival outcomes using the Kaplan-Meier method with patient-level data between HSCT and intravenous pulse cyclophosphamide (IVCY). Additionally, the incidence rate of treatment-related deaths with HSCT was pooled using a random-effect model. Results Of the 2,091 articles screened, 22 were included: 3 randomized controlled trials and 19 observational studies. HSCT studies showed significant improvement in the skin thickness score and lung function. Despite treatment-related deaths being higher in HSCT than in IVCY, the Kaplan-Meier analysis showed a high survival rate 2 years post-transplant (log-rank, P=0.004). The pooled frequency of transplant-related death from 700 SSc patients was 6.30% (95% confidence interval 4.21-8.38). However, the estimated frequency of treatment-related deaths has been reducing over the last decade. Conclusion HSCT is an effective treatment for SSc, but the optimal indications must be carefully determined by balancing the risks.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据