Standpoints in mitochondrial dysfunction: Underlying mechanisms in search of therapeutic strategies

Mitochondrial dysfunction has been defined as a reduced efficiency of mitochondria to produce ATP given by a loss of mitochondrial membrane potential, alterations in the electron transport chain (ETC) function, with in-crease in reactive oxygen species (ROS) generation and decrease in oxygen consumption. During the last decades, mitochondrial dysfunction has been the focus of many researchers as a convergent point for the pathophysiology of several diseases. Numerous investigations have demonstrated that mitochondrial dysfunction is detrimental to

Automated summary

Mitochondrial dysfunction is characterized by a reduced efficiency of ATP production, caused by a loss of mitochondrial membrane potential, alterations in the electron transport chain function, increased generation of reactive oxygen species (ROS), and decreased oxygen consumption. It has been the focus of many researchers as a convergent point for the pathophysiology of several diseases.