Relationship between Gut Microbiota and Bone Health

Gut Microbiota (GM) are microorganisms that live in the host gastrointestinal tract, and their abundance varies throughout the host's life. With the development of sequencing technology, the role of GM in various diseases has been increasingly elucidated. Unlike earlier studies on orthopedic diseases, this review elucidates the correlation between GM health and bone health and discusses the potential mechanism of GM effects on host metabolism, inflammation, and ability to induce or aggravate some common orthopedic diseases, such as osteoarthritis, osteoporosis, rheumatoid arthritis, etc. Finally, the prospective methods of GM manipulation and evaluation of potential GM-targeting strategies in the diagnosis and treatment of orthopedic diseases are reviewed.

Automated summary

This review explores the correlation between gut microbiota (GM) and bone health, discussing the potential mechanisms by which GM affects host metabolism, inflammation, and the development of common orthopedic diseases. The review also evaluates prospective methods of GM manipulation and potential GM-targeting strategies for the diagnosis and treatment of orthopedic diseases.