☆ 4.5 Review

The Immune Response to SARS-CoV-2: Mechanisms, Aging, Sequelae, and Vaccines

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Review Biochemistry & Molecular Biology

PANoptosis in Viral Infection: The Missing Puzzle Piece in the Cell Death Field

Lam Nhat Nguyen et al.

Summary: Viral infections can activate programmed cell death (PCD) pathways, including pyroptosis, apoptosis, and necroptosis. The emerging concept of PANoptosis suggests extensive crosstalk between these PCD pathways. PANoptosis plays a significant role in regulating viral infection, but it can also have different effects on host defense and viral pathogenesis.

JOURNAL OF MOLECULAR BIOLOGY (2022)

添加到收藏夹

Article Chemistry, Medicinal

In Silico Identification of New Anti-SARS-CoV-2 Agents from Bioactive Phytocompounds Targeting the Viral Spike Glycoprotein and Human TLR4

Nabarun Chandra Das et al.

Summary: This study identified two potential inhibitors of the spike glycoprotein of SARS-CoV-2 and also predicted their ability to block human TLR4, suggesting their potential use in mitigating COVID-19-induced immunopathological manifestations. Further experimental validation and toxicological studies are required.

LETTERS IN DRUG DESIGN & DISCOVERY (2022)

添加到收藏夹

Letter Virology

Targeting human TLRs to combat COVID-19: A solution?

Ritwik Patra et al.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Infectious Diseases

Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study

Qiutang Xiong et al.

Summary: The study described the common clinical sequelae in COVID-19 survivors discharged from the hospital for more than 3 months, including general symptoms, respiratory symptoms, cardiovascular-related symptoms, psychosocial symptoms, and alopecia. Female patients were more likely to experience physical decline/fatigue, postactivity polypnoea, and alopecia.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Is Toll-like receptor 4 involved in the severity of COVID-19 pathology in patients with cardiometabolic comorbidities?

Simone Cristina Soares Brandao et al.

Summary: The severe form of COVID-19 is characterized by an abnormal and exacerbated immune response, especially in patients with obesity, diabetes, hypertension, and atherosclerosis. The virus spike protein interacts strongly with TLR4, leading to a cytokine storm and multiple organ failure in some cases.

CYTOKINE & GROWTH FACTOR REVIEWS (2021)

添加到收藏夹

Article Infectious Diseases

Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial

Shengli Xia et al.

Summary: The inactivated SARS-CoV-2 vaccine, BBIBP-CorV, demonstrated safety and immunogenicity in two age groups. Humoral responses against SARS-CoV-2 were induced in all vaccine recipients by day 42. A two-dose immunisation with 4 mu g vaccine on days 0 and 21 or days 0 and 28 achieved higher neutralising antibody titres compared to other dosing schedules.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Review Virology

Severe acute respiratory syndrome-coronavirus-2 spike (S) protein based vaccine candidates: State of the art and future prospects

Arash Arashkia et al.

Summary: COVID-19 is caused by SARS-CoV-2 and an urgent need for the development of a safe and effective vaccine exists to prevent global spread. The spike (S) protein of SARS-CoV-2 plays a crucial role in cell entry and is a key target for vaccine development to induce protective immunity.

REVIEWS IN MEDICAL VIROLOGY (2021)

添加到收藏夹

Editorial Material Geriatrics & Gerontology

Efficacy and safety of COVID-19 vaccines in older people

Roy L. Soiza et al.

Summary: The safety and efficacy of COVID-19 vaccines in older people are crucial for their success, but there is currently a lack of data. While some Phase III trials have made efforts to recruit older people, those with co-morbidities and frailty have still been largely excluded. Older people, their carers, and healthcare professionals will need to make decisions on vaccination acceptance based on limited evidence.

AGE AND AGEING (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes

Rajendra Karki et al.

Summary: The combination of TNF-alpha and IFN-gamma induces inflammatory cell death characterized by PANoptosis, which can be inhibited to protect mice from the pathological effects and death caused by COVID-19. Blocking the cytokine-mediated inflammatory cell death signaling pathway may benefit patients with COVID-19 or other infectious and autoinflammatory diseases by limiting tissue damage/inflammation.

CELL (2021)

添加到收藏夹

Article Virology

In silico analyses on the comparative sensing of SARS-CoV-2 mRNA by the intracellular TLRs of humans

Abhigyan Choudhury et al.

Summary: This study demonstrates the potential role of TLR3, 7, and 9 in COVID-19 immunobiology, with the viral mRNAs of NSP10, S2, and E proteins of SARS-CoV-2 binding to TLR3, TLR9, and TLR7 respectively, triggering downstream inflammatory signaling cascades. The binding of viral mRNAs leads to conformational changes in the ligand-binding domain of TLRs, validating the activation of inflammatory responses.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

添加到收藏夹

Review Cell Biology

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mohamed M. Aboudounya et al.

Summary: Mortality in COVID-19 is caused by respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4, an innate immune receptor, recognizes viral proteins and triggers immune responses. SARS-CoV-2 binds to TLR4, potentially leading to inflammation and multi-organ injury.

MEDIATORS OF INFLAMMATION (2021)

添加到收藏夹

Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

添加到收藏夹

Review Immunology

T Cells: Warriors of SARS-CoV-2 Infection

Paola de Candia et al.

Summary: Severe infection with SARS-CoV-2 is characterized by massive cytokine release and T cell loss. The exaggerated host immune response, possibly dependent on T cell immunological memory, may significantly contribute to immunopathology and massive collateral damage in COVID-19 patients, especially in adults compared with children.

TRENDS IN IMMUNOLOGY (2021)

添加到收藏夹

Review Virology

Viral Evasion of RIG-I-Like Receptor-Mediated Immunity through Dysregulation of Ubiquitination and ISGylation

Cindy Chiang et al.

Summary: Viral manipulation of ubiquitin or ISG15-mediated immune responses is a key strategy for virus evasion, including direct targeting of ubiquitin E3 ligases, active deubiquitination using viral DUBs, and the upregulation of cellular DUBs to regulate RLR signaling. Certain coronaviruses, such as SARS-CoV-2, actively deISGylate key molecules in the RLR pathway to escape type I interferon-mediated antiviral responses. Targeting virally-encoded proteins that manipulate ubiquitin or ISG15-mediated innate immune responses may be a potential strategy for the development of new antivirals and vaccines.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Critical Care Medicine

A Clinic Blueprint for Post-Coronavirus Disease 2019 RECOVERY Learning From the Past, Looking to the Future

Denyse D. Lutchmansingh et al.

Summary: The COVID-19 pandemic has led to a significant number of survivors facing prolonged symptoms, prompting the need for multidisciplinary post-COVID-19 clinics. Understanding the acute disease and emerging data is crucial for addressing persistent symptoms and long-term complications, while effective collaboration between physicians and researchers is essential in shaping the treatment of acute disease and chronic complications. A successful multidisciplinary model must leverage early pandemic lessons to overcome logistical challenges and meet the needs of COVID-19 survivors.

CHEST (2021)

添加到收藏夹

Article Respiratory System

Diffusion Capacity Abnormalities for Carbon Monoxide in Patients with COVID-19 At Three-Month Follow-up

Wei Qin et al.

EUROPEAN RESPIRATORY JOURNAL (2021)

添加到收藏夹

Review Virology

Role of Toll-like receptors in the pathogenesis of COVID-19

Shaghayegh Khanmohammadi et al.

Summary: COVID-19 caused by SARS-CoV-2 has led to a pandemic. TLRs play a crucial role in activating the immune system in response to the virus, and could potentially be a target for controlling the infection. Understanding the mechanisms of TLR in COVID-19 may help in developing vaccines and treatments.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy adults aged 60 years and older: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Zhiwei Wu et al.

Summary: The study showed that CoronaVac vaccine is safe and well tolerated in older adults, and is able to induce neutralizing antibody levels. The highest dose of 3 μg of the vaccine can generate neutralizing antibody levels similar to the 6 μg dose, supporting the use of the 3 μg dose CoronaVac in phase 3 trials.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine in healthy adults aged 18-59 years: a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial

Yanjun Zhang et al.

Summary: This study investigated the safety, tolerability, and immunogenicity of the COVID-19 vaccine candidate CoronaVac, and found that the 3 μg dose showed higher seroconversion rates in the phase 2 trial.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors

Jerzy Osipiuk et al.

Summary: The study focused on papain-like protease (PLpro) as a potential target for antivirals against SARS-CoV-2, identifying inhibitors and their interactions with the enzyme. The findings demonstrate the potential for developing high-affinity inhibitors through structure-based drug design efforts targeting PLpro.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biology

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Chiara Fallerini et al.

Summary: Loss-of-function variants in TLR7 were found to be associated with severe COVID-19 in young males, representing a subset of male patients and contributing to disease susceptibility in approximately 2% of severe COVID-19 cases. This study provides insight into the genetic factors influencing COVID-19 severity in male patients.

ELIFE (2021)

添加到收藏夹

Article Virology

Exploring the binding efficacy of ivermectin against the key proteins of SARS-CoV-2 pathogenesis: an in silico approach

Abhigyan Choudhury et al.

Summary: The study suggests that ivermectin may act as a blocker of key proteins in SARS-CoV-2 pathogenesis, showing similar antiviral efficacy and safety profile to currently used drugs such as hydroxychloroquine and remdesivir. It illuminates the potential of ivermectin as an effective treatment for COVID-19.

FUTURE VIROLOGY (2021)

添加到收藏夹

Review Immunology

Chemotherapy vs. Immunotherapy in combating nCOVID19: An update

Abhigyan Choudhury et al.

Summary: The COVID-19 pandemic originated in Wuhan and has spread globally, causing millions of deaths with no credible cure yet. Chemotherapeutic and immunotherapeutic approaches are promising strategies for the management and potential cure, aiming to interrupt virus-host interactions and modulate host immunity to combat the virus and restore immune homeostasis. Combinatorial therapy involving chemotherapy and vaccines may offer hope to eradicate the crisis.

HUMAN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

TLR2 senses the SARS-CoV-2 envelope protein to produce inflammatory cytokines

Min Zheng et al.

Summary: The study revealed that the envelope protein of SARS-CoV-2 is sensed by TLR2, leading to the production of inflammatory cytokines, and the severity of the disease is associated with the expression of TLR2 and MYD88. The findings demonstrate the critical role of TLR2 signaling in promoting proinflammatory cytokine production during coronavirus infection, providing new insights for therapeutic strategies against the ongoing COVID-19 pandemic.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Post-acute COVID-19 syndrome

Ani Nalbandian et al.

Summary: SARS-CoV-2 is responsible for the COVID-19 pandemic, causing global healthcare crises. Recovery from COVID-19 may lead to persistent symptoms and long-term complications, prompting the need for multidisciplinary care and follow-up for survivors.

NATURE MEDICINE (2021)

添加到收藏夹

Article Microbiology

ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity

GuanQun Liu et al.

Summary: Conjugation of ISG15 plays a crucial role in activating the RIG-I-like receptor MDA5 and triggering antiviral responses, while SARS-CoV-2 suppresses MDA5 activation through direct de-ISGylation to evade innate immunity.

NATURE MICROBIOLOGY (2021)

添加到收藏夹

Review Microbiology

COVID-19: Insights into Potential Vaccines

Ke-Yan Loo et al.

Summary: The fear of COVID-19 loomed over the global population as they welcomed the new year in 2021, with millions infected and lives at risk. Pharmaceutical companies swiftly developed various types of vaccines, with several already authorized for emergency use, while others await approval.

MICROORGANISMS (2021)

添加到收藏夹

Review Medicine, General & Internal

Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data

Francesca Salamanna et al.

Summary: A substantial proportion of COVID-19 patients experience long-term symptoms after recovery, including abnormal lung functions, neurologic complaints, olfactory dysfunctions, chronic fatigue, and pain. Despite the heterogeneity in studies, findings highlight the presence of a post-COVID syndrome in a noteworthy proportion of patients who have suffered from SARS-CoV-2 infection.

FRONTIERS IN MEDICINE (2021)

添加到收藏夹

Review Allergy

Mechanisms underlying host defense and disease pathology in response to severe acute respiratory syndrome (SARS)-CoV2 infection: insights from inborn errors of immunity

Stuart G. Tangye et al.

Summary: The COVID-19 pandemic has highlighted the crucial role of the immune system in defense against emerging pathogens. Studying severe cases in patients with IEI has led to key insights into immunology, disease pathogenesis, and immunopathology, which can improve therapies for infectious diseases.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

添加到收藏夹

Review Cell Biology

Severe Acute Respiratory Syndrome Coronavirus 2: The Role of the Main Components of the Innate Immune System

Akbar Anaeigoudari et al.

Summary: The COVID-19 pandemic began in Wuhan, China in late 2019, affecting individuals with varying clinical manifestations. Immunity plays a crucial role in defense against the virus and recovery from the disease, with the innate immune system serving as the first line of defense and activating acquired immunity in response to virus detection.

INFLAMMATION (2021)

添加到收藏夹

Article Virology

COVID-19-associated Guillain-Barre syndrome: Postinfectious alone or neuroinvasive too?

Farman Khan et al.

Summary: COVID-19 has been associated with various neurological complications, with GBS being an important post-infectious consequence. This study found SARS-CoV-2 in the CSF of an adult patient for the first time, highlighting the need to consider separate pathogenesis in cases where COVID-19 symptoms and GBS occur concurrently. The study also suggests a neuroinvasive potential of SARS-CoV-2.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Infectious Diseases

Safety, tolerability, and immunogenicity of an inactivated SARS-CoV-2 vaccine (CoronaVac) in healthy children and adolescents: a double-blind, randomised, controlled, phase 1/2 clinical trial

Bihua Han et al.

Summary: The study evaluated the safety, tolerability, and immunogenicity of the candidate COVID-19 vaccine CoronaVac containing inactivated SARS-CoV-2 in children and adolescents aged 3-17 years. The research findings indicate that the 3.0 μg dose induced higher levels of neutralizing antibodies compared to the 1.5 μg dose, supporting the use of the 3.0 μg dose for further studies in this age group.

LANCET INFECTIOUS DISEASES (2021)

添加到收藏夹

Editorial Material Immunology

SARS-CoV-2 takes its Toll

Alan Sariol et al.

NATURE IMMUNOLOGY (2021)

添加到收藏夹

Review Immunology

Unraveling the Mystery Surrounding Post-Acute Sequelae of COVID-19

Rakhee K. Ramakrishnan et al.

Summary: COVID-19 has been present for over a year with limited treatment options available. Some recovered patients experience lingering symptoms, known as long COVID-19, possibly due to a persistent immune response causing ongoing inflammation processes.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

Xavier Solanich et al.

Summary: The study found loss-of-function TLR7 variants in young men with severe COVID-19, which may result in weakened interferon responses to the virus. Additionally, siblings of two patients carrying the variants also showed different degrees of disease symptoms, indicating a potential genetic predisposition.

FRONTIERS IN IMMUNOLOGY (2021)

添加到收藏夹

Article Immunology

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19

Aldo Bonaventura et al.

Summary: The authors suggest that SARS-CoV-2 infection induces a prothrombotic state and dysregulated immunothrombosis, leading to severe manifestations of COVID-19. They also discuss potential antithrombotic and immunomodulating drugs for treating COVID-19 patients, aiming to reduce the acute and long-term consequences of the disease by targeting immunothrombosis.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Review Multidisciplinary Sciences

Current progress and challenges in the design and development of a successful COVID-19 vaccine

Tingting Li et al.

Summary: With over 200 COVID-19 vaccine candidates currently in development, there are numerous scientific and practical challenges that need to be addressed. The successful design of a vaccine is essential for effectively combating the pandemic.

FUNDAMENTAL RESEARCH (2021)

添加到收藏夹

Review Geriatrics & Gerontology

Review of COVID-19 Vaccines and Their Evidence in Older Adults

Shyh Poh Teo

Summary: The COVID-19 pandemic has had a significant impact on older adults, making them a priority group for vaccination. Different types of COVID-19 vaccines have shown varying effectiveness in older adults, with some vaccines demonstrating high efficacy and immunogenicity in this population. However, further research is needed to clarify the dosage of some vaccines.

ANNALS OF GERIATRIC MEDICINE AND RESEARCH (2021)

添加到收藏夹

Review Immunology

Viral targets for vaccines against COVID-19

Lianpan Dai et al.

Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Article Medicine, General & Internal

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang et al.

LANCET (2020)

添加到收藏夹

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

添加到收藏夹

Editorial Material Public, Environmental & Occupational Health

Wuhan novel coronavirus (COVID-19): why global control is challenging?

A. Lee

PUBLIC HEALTH (2020)

添加到收藏夹

Article Endocrinology & Metabolism

COVID-19 pandemic, coronaviruses, and diabetes mellitus

Ranganath Muniyappa et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Oxidative Stress as Key Player in Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) Infection

Livan Delgado-Roche et al.

ARCHIVES OF MEDICAL RESEARCH (2020)

添加到收藏夹

Review Immunology

Should we stimulate or suppress immune responses in COVID-19? Cytokine and anti-cytokine interventions

Yvan Jamilloux et al.

AUTOIMMUNITY REVIEWS (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

Qihui Wang et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals

Alba Grifoni et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Review Cardiac & Cardiovascular Systems

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System Celebrating the 20th Anniversary of the Discovery of ACE2

Mahmoud Gheblawi et al.

CIRCULATION RESEARCH (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Cytokine storm intervention in the early stages of COVID-19 pneumonia

Xinjuan Sun et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

IL-6: Relevance for immunopathology of SARS-CoV-2

E. O. Gubernatorova et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2020)

添加到收藏夹

Article Immunology

Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan

Jasper Fuk-Woo Chan et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Correction Critical Care Medicine

Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China (vol 17, pg 851, 2020)

Qiurong Ruan et al.

INTENSIVE CARE MEDICINE (2020)

添加到收藏夹

Review Infectious Diseases

Prevalence of comorbidities and its effects in patients infected with SARS-CoV-2: a systematic review and meta-analysis

Jing Yang et al.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Medicine, General & Internal

Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China

An Pan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Article Allergy

Type 2 inflammation modulates ACE2 and TMPRSS2 in airway epithelial cells

Hiroki Kimura et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Review Virology

Immune responses and pathogenesis of SARS-CoV-2 during an outbreak in Iran: Comparison with SARS and MERS

Mohsen Rokni et al.

REVIEWS IN MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Development of an inactivated vaccine candidate for SARS-CoV-2

Qiang Gao et al.

SCIENCE (2020)

添加到收藏夹

Article Virology

In silico studies on the comparative characterization of the interactions of SARS-CoV-2 spike glycoprotein with ACE-2 receptor homologs and human TLRs

Abhigyan Choudhury et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

添加到收藏夹

Article Immunology

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

Dandan Wu et al.

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

Javier A. Jaimes et al.

JOURNAL OF MOLECULAR BIOLOGY (2020)

添加到收藏夹

Article Medical Laboratory Technology

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases

Cynthia Magro et al.

TRANSLATIONAL RESEARCH (2020)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

ABO blood group predisposes to COVID-19 severity and cardiovascular diseases

Xiaofeng Dai

EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY (2020)

添加到收藏夹

Article Microbiology

The hallmarks of COVID-19 disease

Daolin Tang et al.

PLoS Pathogens (2020)

添加到收藏夹

Editorial Material Hematology

Thromboinflammation and the hypercoagulability of COVID-19

Jean M. Connors et al.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2020)

添加到收藏夹

Article Medicine, General & Internal

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China

Chaomin Wu et al.

JAMA INTERNAL MEDICINE (2020)

添加到收藏夹

Article Oncology

SARS-CoV-2 infection and overactivation of Nlrp3 inflammasome as a trigger of cytokine storm and risk factor for damage of hematopoietic stem cells

Mariusz Z. Ratajczak et al.

LEUKEMIA (2020)

添加到收藏夹

Article Rheumatology

On the Alert for Cytokine Storm: Immunopathology in COVID-19

Lauren A. Henderson et al.

ARTHRITIS & RHEUMATOLOGY (2020)

添加到收藏夹

Article Immunology

Novel Coronavirus-Induced NLRP3 Inflammasome Activation: A Potential Drug Target in the Treatment of COVID-19

Adnan Shah

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

Bo Diao et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

添加到收藏夹

News Item Multidisciplinary Sciences

THE RACE FOR CORONAVIRUS VACCINES

Ewen Callaway

NATURE (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-Xin Long et al.

NATURE MEDICINE (2020)

添加到收藏夹

Review Immunology

Recent Insight into SARS-CoV2 Immunopathology and Rationale for Potential Treatment and Preventive Strategies in COVID-19

Sara Lega et al.

VACCINES (2020)

添加到收藏夹

Review Infectious Diseases

The genetic sequence, origin, and diagnosis of SARS-CoV-2

Huihui Wang et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2

Hui Wang et al.

CELL (2020)

添加到收藏夹

Review Cell Biology

The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of inflame-aging

Gholam Hossein Meftahi et al.

INFLAMMATION RESEARCH (2020)

添加到收藏夹

Review Pharmacology & Pharmacy

A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic

Colin D. Funk et al.

FRONTIERS IN PHARMACOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

COVID-19: The Immune Responses and Clinical Therapy Candidates

Sareh Zhand et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Presence of Genetic Variants Among Young Men With Severe COVID-19

Caspar I. van der Made et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Hypercoagulopathy and Adipose Tissue Exacerbated Inflammation May Explain Higher Mortality in COVID-19 Patients With Obesity

Gabriel Pasquarelli-do-Nascimento et al.

FRONTIERS IN ENDOCRINOLOGY (2020)

添加到收藏夹

Review Medicine, General & Internal

The four horsemen of a viral Apocalypse: The pathogenesis of SARS-CoV-2 infection (COVID-19)

Pere Domingo et al.

EBIOMEDICINE (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Characteristics and diagnosis rate of 5630 subjects receiving SARS-CoV-2 nucleic acid tests from Wuhan, China

Na Shen et al.

JCI INSIGHT (2020)

添加到收藏夹

Article Medicine, Research & Experimental

The laboratory tests and host immunity of COVID-19 patients with different severity of illness

Feng Wang et al.

JCI INSIGHT (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The complement system in COVID-19: friend and foe?

Anuja Java et al.

JCI INSIGHT (2020)

添加到收藏夹

Review Cell Biology

Cytokine storm and leukocyte changes in mild versus severe SARS-CoV-2 infection: Review of 3939 COVID-19 patients in China and emerging pathogenesis and therapy concepts

Jin Wang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

添加到收藏夹

Article Hematology

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

Eugenio D. Hottz et al.

BLOOD (2020)

添加到收藏夹

Review Cell Biology

Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment

Sebastiano Cicco et al.

MEDIATORS OF INFLAMMATION (2020)

添加到收藏夹

Letter Medicine, Research & Experimental

May IL-17 have a role in COVID-19 infection?

Matteo Megna et al.

MEDICAL HYPOTHESES (2020)

添加到收藏夹

Article Oncology

SARS-CoV-2 Viral Load Predicts Mortality in Patients with and without Cancer Who Are Hospitalized with COVID-19

Lars F. Westblade et al.

CANCER CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

Kizzmekia S. Corbett et al.

NATURE (2020)

添加到收藏夹

Article Multidisciplinary Sciences

ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques

Neeltje van Doremalen et al.

NATURE (2020)

添加到收藏夹

Editorial Material Rheumatology

Autoimmune and inflammatory diseases following COVID-19

Caroline Galeotti et al.

NATURE REVIEWS RHEUMATOLOGY (2020)

添加到收藏夹

Review Immunology

Vaccines for COVID-19

J. S. Tregoning et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2020)

添加到收藏夹

Review Virology

COVID-19 Vaccine: A comprehensive status report

Simran Preet Kaur et al.

VIRUS RESEARCH (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Deciphering SARS-CoV-2 Virologic and Immunologic Features

Gregorie Lebeau et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

添加到收藏夹

Article Allergy

Allergic disorders and susceptibility to and severity of COVID-19: A nationwide cohort study

Jee Myung Yang et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

添加到收藏夹

Review Medicine, General & Internal

SARS-CoV-2 immunity: review and applications to phase 3 vaccine candidates

Gregory A. Poland et al.

LANCET (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions

Abdollah Jafarzadeh et al.

LIFE SCIENCES (2020)

添加到收藏夹

Review Medicine, Research & Experimental

The immune system and COVID-19: Friend or foe?

Fereshteh Yazdanpanah et al.

LIFE SCIENCES (2020)

添加到收藏夹

Article Medicine, General & Internal

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

E. J. Anderson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Review Immunology

The Immune Response and Immunopathology of COVID-19

Esmaeil Mortaz et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

The emergence of COVID-19 as a global pandemic: Understanding the epidemiology, immune response and potential therapeutic targets of SARS-CoV-2

Shibi Muralidar et al.

BIOCHIMIE (2020)

添加到收藏夹

Article Immunology

Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets

V. Kumar

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

添加到收藏夹

Article Medicine, General & Internal

Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Maheshi N. Ramasamy et al.

LANCET (2020)

添加到收藏夹

Article Medicine, Research & Experimental

The potential use of ABO blood group system for risk stratification of COVID-19

Antoine Fakhry AbdelMassih et al.

MEDICAL HYPOTHESES (2020)

添加到收藏夹

Review Endocrinology & Metabolism

Obesity in patients with COVID-19: a systematic review and meta-analysis

Yi Huang et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2020)

添加到收藏夹

Article Medicine, Research & Experimental

Mitochondrial-targeted ubiquinone: A potential treatment for COVID-19

Lichen Ouyang et al.

MEDICAL HYPOTHESES (2020)

添加到收藏夹

Review Immunology

Adjuvants for Coronavirus Vaccines

Zhihui Liang et al.

FRONTIERS IN IMMUNOLOGY (2020)

添加到收藏夹

Article Multidisciplinary Sciences

SARS-CoV-2 viral load is associated with increased disease severity and mortality

Jesse Fajnzylber et al.

NATURE COMMUNICATIONS (2020)

添加到收藏夹

Article Immunology

Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibody Responses in Coronavirus Disease Patients

Nisreen M. A. Okba et al.

EMERGING INFECTIOUS DISEASES (2020)

添加到收藏夹

Article Genetics & Heredity

Evaluating of the association between ABO blood groups and coronavirus disease 2019 (COVID-19) in Iraqi patients

Ali H. Ad'hiah et al.

EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS (2020)

添加到收藏夹

Review Immunology

Immunological considerations for COVID-19 vaccine strategies

Mangalakumari Jeyanathan et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Considering how biological sex impacts immune responses and COVID-19 outcomes

Eileen P. Scully et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

T cell responses in patients with COVID-19

Zeyu Chen et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Article Immunology

Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages

Miriam Merad et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Review Immunology

The trinity of COVID-19: immunity, inflammation and intervention

Matthew Zirui Tay et al.

NATURE REVIEWS IMMUNOLOGY (2020)

添加到收藏夹

Review Infectious Diseases

The epidemiology and clinical information about COVID-19

Huipeng Ge et al.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2020)

添加到收藏夹

Letter Biochemistry & Molecular Biology

Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study

Li Tan et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Immune Response and COVID-19: A mirror image of Sepsis

Eduardo Lopez-Collazo et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

添加到收藏夹

Article Immunology

Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients

Yong Xiong et al.

EMERGING MICROBES & INFECTIONS (2020)

添加到收藏夹

Review Virology

Viral Innate Immune Evasion and the Pathogenesis of Emerging RNA Virus Infections

Tessa Nelemans et al.

VIRUSES-BASEL (2019)

添加到收藏夹

Review Cell Biology

Platelet TLR4 at the crossroads of thrombosis and the innate immune response

Mirta Schattner

JOURNAL OF LEUKOCYTE BIOLOGY (2019)

添加到收藏夹

Review Immunology

Advances in mRNA Vaccines for Infectious Diseases

Cuiling Zhang et al.

FRONTIERS IN IMMUNOLOGY (2019)

添加到收藏夹

Review Biotechnology & Applied Microbiology

mRNA vaccines - a new era in vaccinology

Norbert Pardi et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Chemopreventive Effects of Phytochemicals and Medicines on M1/M2 Polarized Macrophage Role in Inflammation-Related Diseases

Yen-Chun Koh et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

添加到收藏夹

Review Immunology

Sex Hormones in Acquired Immunity and Autoimmune Disease

Vaishali R. Moulton

FRONTIERS IN IMMUNOLOGY (2018)

添加到收藏夹

Review Immunology

Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology

Rudragouda Channappanavar et al.

SEMINARS IN IMMUNOPATHOLOGY (2017)

添加到收藏夹

Article Immunology

Cutting Edge: Synchronization of IRF1, JunB, and C/EBPβ Activities during TLR3-TLR7 Cross-Talk Orchestrates Timely Cytokine Synergy in the Proinflammatory Response

Qian Liu et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Immunology

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-α Production in Women

Morgane Griesbeck et al.

JOURNAL OF IMMUNOLOGY (2015)

添加到收藏夹

Article Virology

Severe acute respiratory syndrome coronavirus E protein transports calcium ions and activates the NLRP3 inflammasome

Jose L. Nieto-Torres et al.

VIROLOGY (2015)

添加到收藏夹

Review Cell Biology

Respiratory viral infection, epithelial cytokines, and innate lymphoid cells in asthma exacerbations

Rakesh K. Kumar et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2014)

添加到收藏夹

Review Immunology

Developments in Viral Vector-Based Vaccines

Takehiro Ura et al.

VACCINES (2014)

添加到收藏夹

Review Microbiology

Into the Eye of the Cytokine Storm

Jennifer R. Tisoncik et al.

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS (2012)

添加到收藏夹

Article Virology

Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH-and Cysteine Protease-Independent FcγR Pathway

Martial Jaume et al.

JOURNAL OF VIROLOGY (2011)

添加到收藏夹

Article Biochemistry & Molecular Biology

Inhibition of the interaction between the SARS-CoV Spike protein and its cellular receptor by anti-histo-blood group antibodies

Patrice Guillon et al.

GLYCOBIOLOGY (2008)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.