☆ 4.4 Review

A year in review in Minerva Anestesiologica 2021 Anesthesia, analgesia, and perioperative medicine

MINERVA ANESTESIOLOGICA (2022)

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Letter Anesthesiology

Defining the optimal spread of local anesthetic during pericapsular nerve group (PENG) block may help to avoid short-term motor block (reply to Aliste et al)

Giuseppe Pascarella et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2022)

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Letter Anesthesiology

Pressure monitoring devices may undetect epidural space: a report on the use of Compuflo® system for epidural injection

Massimiliano Carassiti et al.

Summary: The Compuflo pressure monitoring device can aid in the correct positioning of an epidural needle, but may sometimes yield false negative results, indicating a need for further research and specific settings for this epidural system. Therefore, in chronic pain patients, this anesthetic technique should only be used by experienced hands.

JOURNAL OF CLINICAL MONITORING AND COMPUTING (2022)

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Article Anesthesiology

Physiological effects of two driving pressure-based methods to set positive end-expiratory pressure during one lung ventilation

Savino Spadaro et al.

Summary: This study compared two different PEEP titration strategies on respiratory mechanics, ventilation/perfusion mismatch, and gas exchange, showing that PEEP (DECREMENTAL) improved oxygenation and lowered intraoperative Delta P.

JOURNAL OF CLINICAL MONITORING AND COMPUTING (2021)

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Review Anesthesiology

Mechanisms of action of the erector spinae plane (ESP) block: a narrative review

Ki Jinn Chin et al.

Summary: The possible mechanisms of analgesia for the ESP block include neural blockade, central inhibition, direct spread of local anesthetic, elevated plasma concentrations, immunomodulatory effects, and mechanosensory properties. The primary mechanism is likely the direct effect of local anesthetic via physical spread to neural structures. Evidence for other proposed mechanisms is limited and speculative at present.

CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE (2021)

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Review Clinical Neurology

Dexmedetomidine as an Adjunct for Regional Anesthetic Nerve Blocks

Srikantha Rao et al.

Summary: Recent studies suggest that dexmedetomidine can prolong the duration of intravenous regional anesthesia, peripheral nerve blocks, and spinal analgesia. However, the potential neurotoxicity of perineural dexmedetomidine in diabetic neuropathy patients remains controversial and requires further evaluation.

CURRENT PAIN AND HEADACHE REPORTS (2021)

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Article Anesthesiology

The effects of two-handed jaw thrust on i-gel™ placement in anesthetized non-paralyzed patients

Hyub Huh et al.

Summary: The two-handed jaw thrust technique facilitated i-gel insertion compared to the conventional technique in anesthetized non-paralyzed patients, with increased first attempt success rate, higher air leakage pressure, shorter insertion time, and reduced incidence of postoperative sore throat.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Ultrasound-guided parasternal blocks: techniques, clinical indications and future prospects

Giuseppe Sepolvere et al.

Summary: Fascial plane blocks are anesthetic procedures used to manage perioperative and chronic pain, with recent advances in techniques such as ultrasound parasternal blocks. These blocks offer effective anesthesia and analgesia with low risk, particularly targeting the antero-medial chest wall to provide pain relief for various surgeries and pain management situations.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Wound infiltration of dexmedetomidine as an adjunct to local anesthesia in postoperative analgesia for lumbar surgery

Hui Dong et al.

Summary: Infiltration of dexmedetomidine significantly reduces postoperative pain scores, prolongs time to first rescue analgesia, and decreases the incidence of nausea or vomiting, making it a promising adjunct for pain control after lumbar surgery.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

Dexmedetomidine: the most versatile and multitasking of anesthetics

Alessandro Di Filippo et al.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Safety and efficacy of remimazolam compared with propofol in induction of general anesthesia

Guangrong Dai et al.

Summary: Remimazolam demonstrates good efficacy and high safety during general anesthesia induction, with lower rates of hypotension and injection site pain compared to propofol.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Perioperative management of spinal cord injury: the anesthesiologist's point of view

Davide Furlan et al.

Summary: Traumatic spinal cord injury is a devastating event which requires systematic perioperative management. Respiratory complications are common, and careful fluid management and patient positioning are crucial during surgery. Individualized perioperative management can improve outcomes and reduce complications.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Neuropathic component of postoperative pain for predicting post-cesarean chronic pain at three months: a prospective observational study

Maria C. Rodriguez Roca et al.

Summary: The study found that patients experiencing neuropathic pain one week after cesarean section are more likely to develop chronic pain at three months post-operation. Other identified risk factors for post-cesarean section chronic pain include specific aspects of the cesarean section procedure.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

Measuring cognitive workload and response time for airway management: will this help decide which airway equipment is safer and more efficient?

Lorraine J. Foley

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Anesthesia for the elderly: a narrative review

Cynthia Olotu

Summary: Perioperative management for elderly patients should be tailored to meet their specific needs, with a focus on comprehensive preoperative assessments, maintaining functionality, and preventing cognitive decline. Adjustments to routine care processes are often only needed to improve postoperative outcomes for this vulnerable and growing group of patients.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

Remimazolam: an ultrashort-acting intravenous anesthetic suitable for general anesthesia

Luigi Cardia

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Effects of direct laryngoscopy versus Glidescope videolaryngoscopy on subjective and objective measures of cognitive workload: an in-vivo randomized trial

Costanza Vuolato et al.

Summary: This study found that using a videolaryngoscope with hyperangulated blade in a real clinical setting significantly reduces both subjective and objective cognitive workload compared to a direct laryngoscope. There is a significant positive correlation between subjective workload and reaction times during the procedures.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Pain, the unknown: epistemological issues and related clinical implications

Enrico Facco

Summary: Despite significant advancements in pain management, pain remains elusive due to its subjective nature and patients often struggle between low drug efficacy and overuse. Pain is not just a symptom, but an essential aspect of life, consciousness, and connection with the world, with intensity and tolerability personalized to the patient's interpretation. The shift towards a patient-centered approach utilizing techniques such as hypnosis can help improve pain management and decrease reliance on pharmacological therapies.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

Anesthesia in the elderly: an increasingly common practice

Andrea Gentili

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Comparison of ropivacaine plasma concentration after posterior Quadratus Lumborum Block in Cesarean Section with ropivacaine with epinephrine vs. plane

Bruno A. Zanfini et al.

Summary: The study showed that adding epinephrine to ropivacaine for pQLB in cesarean section surgery can increase efficacy and duration of the block, as well as reduce the risk of local anesthetic systemic toxicity.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Effect of sugammadex on the recovery of gastrointestinal motility after open pancreaticoduodenectomy: a single-center retrospective study

Hye-Yeon Cho et al.

Summary: The study found that the use of sugammadex was significantly associated with a decrease in delayed passage of first flatus and oral intake tolerance following open pancreaticoduodenectomy compared to other reversal agents.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Left paratracheal pressure versus cricoid pressure for successful laryngeal mask airway insertion in adult patients: a randomized, non-inferiority trial

Min Hur et al.

Summary: In adult patients undergoing general anesthesia, Left paratracheal pressure (LPP) was shown to be non-inferior to Cricoid pressure (CP) in the success rate of Laryngeal Mask Airway (LMA) insertion on the first attempt.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Comparison of LMA® Gastro™ airway and gastrolaryngeal tube in endoscopic retrograde cholangiopancreatography: a prospective randomized observational trial

Harun Uysal et al.

Summary: The study compared the performance of LMA Gastro and GLT airway devices in ERCP, finding that LMA Gastro had higher oropharyngeal leak pressure (OLP) but GLT was preferred by endoscopists. The LMA Gastro group had lower rates of mucosal damage and sore throat.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

May the force be with you (but elsewhere): time to rethink cricoid pressure?

Massimiliano Sorbello et al.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

Place your bets: pediatric pain is no longer a game for gamblers

Marco Rossi et al.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

ECG changes after non-cardiac surgery: a prospective observational study in intermediate-high risk patients

Gil Marcus et al.

Summary: The study found that in intermediate-high risk surgical patients, approximately 62.2% of patients showed pathological changes in their preoperative ECG. Postoperatively, new ECG pathologies were documented in 49.8% of patients, with T-wave changes (36.4%) being the most common. Factors such as diabetes, history of ischemic heart disease, higher volumes of fluid replacement, and higher levels of preoperative hemoglobin were independently associated with postoperative ECG changes.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Anesthetic management of peripartum cardiomyopathy

David Turnbull

Summary: Patients with PPCM are at risk of rapid unpredictable decline and should be managed in specialist centers. Neither regional nor general anesthetic interventions have a discernible impact on the outcome of PPCM patients, with a mortality rate of 5-6%.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Comparison of remifentanil consumption in pupillometry-guided versus conventional administration in children: a randomized controlled trial

Sheung-Nyoung Choi et al.

Summary: Pupillometry-guided remifentanil administration in children undergoing general anesthesia can significantly reduce intraoperative remifentanil consumption without affecting intra- and postoperative blood pressure and heart rate.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Audit of international intraoperative hemotherapy and blood loss documentation on anesthetic records

Florian Piekarski et al.

Summary: Most evaluated anesthetic records lack relevant fields for perioperative hemotherapy, hemostatic therapy, and diagnostics. Guidelines and protocols for anesthetic documentation should include these topics to ensure information transfer and patient safety.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Future in regional anesthesia and pain medicine: the pharmacological view

Stanley Jablonski et al.

Summary: Local anesthetics primarily target voltage-gated sodium channels, leading to temporary nerve conduction interruption. However, they are not specific to blocking certain channels or cell types. Research has focused on extending duration of action, targeting nociceptors, specific isoforms, and combining with other analgesics.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Airways ultrasound in predicting difficult face mask ventilation

Amedeo Bianchini et al.

Summary: Preoperative upper airway ultrasound measurements can predict difficult mask ventilation situations. The thickness of the base of the tongue and the hyomental distance have predictive roles in difficult ventilation situations.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Future in regional anesthesia: new techniques and technological advancements

Ece Yamak Altinpulluk et al.

Summary: It can be seen that with advances in technology, the field of regional anesthesia has undergone continuous improvements and innovations, making block techniques safer and more effective. The use of new extended-release local anesthetic agents provides a more long-lasting analgesic effect with a single injection.

MINERVA ANESTESIOLOGICA (2021)

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Editorial Material Anesthesiology

Moving past Mallampati: airway ultrasound in predicting difficult face mask ventilation

Lev Deriy et al.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Neuromuscular blockade management and postoperative outcomes in enhanced recovery colorectal surgery: secondary analysis of POWER trial

Ana B. Serrano et al.

Summary: The study found that optimal neuromuscular blockade management in colorectal surgery did not lead to reduced moderate-severe complications, length of hospital stay, or mortality postoperatively within an enhanced recovery program. Reversing neuromuscular blockade with neostigmine was associated with a higher mortality rate compared to using sugammadex.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Hemoadsorption: effective in reducing circulating fragments of the endothelial glycocalyx during cardiopulmonary bypass in patients undergoing on-pump cardiac surgery?

Andreas Hohn et al.

Summary: The study demonstrated that the novel hemoadsorption device was able to effectively adsorb HEP from circulation, but blood concentrations of HYA, SYN, and ANP could not be reduced during CPB in patients undergoing on-pump cardiac surgery.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Sublingual sufentanil tablet system for the management of acute postoperative pain in a hospital setting: an observational study

Marco Scardino et al.

Summary: The study evaluated the efficacy, safety, and usability of SSTS for post-surgical analgesia in a real-life setting, demonstrating that SSTS provides effective pain management and is easy to use for patients and nurses under real-life clinical practice.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

PEEP in thoracic anesthesia: pros and cons

Denise Battaglini et al.

Summary: Protective ventilation includes strategies such as low tidal volume, Plateau pressure, driving pressure, PEEP, and recruitment maneuvers. While PEEP can minimize atelectrauma during OLV, it may also increase pulmonary vascular resistance and hemodynamic impairment, especially under high oxygen levels. Titrating PEEP based on driving pressure may have positive effects on respiratory and pulmonary compliance, but should be tailored to individual patients.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Chronic cancer and non-cancer pain and opioid-induced hyperalgesia share common mechanisms: neuroinflammation and central sensitization

Angela Santoni et al.

Summary: Neuroinflammation is a unique form of inflammation that affects both cancer and non-cancer pain. The tumor microenvironment and long-term opioid use can contribute to neuroinflammation, exacerbating rather than alleviating pain.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Opioid free anesthesia: evidence for short and long-term outcome

Dario Bugada et al.

Summary: The historical use of synthetic opioids in anesthesia has been reevaluated, with a shift towards opioid-free anesthesia (OFA) for better perioperative outcomes. OFA combines various drugs and techniques to provide effective analgesia with fewer opioid-related side effects, showing promising results. Further research is needed to determine the long-term effects and optimal approach for each patient, but interest in OFA is growing.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Pericapsular nerve group block: an overview

Romualdo Del Buono et al.

Summary: The PENG block is a newly described ultrasound-guided technique for pain management in the hip. The main indication is hip-related analgesia, with the most commonly injected drug being a 20ml long-acting local anesthetic. No major complications have been reported so far.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Comparison of the analgesic effect of quadratus lumborum block and epidural block in open uterine surgery: a randomized controlled trial

Huiyu She et al.

Summary: The study found that in open uterine surgery, although the QLB group had higher remifentanil consumption during surgery, cumulative sufentanil consumption within 24 hours post-surgery was similar between the QLB and EB groups. The QLB group had lower ephedrine requirements, higher lower limb muscle strength, and lower nausea incidence.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Effectiveness and validity of midsagittal tongue cross-sectional area and width measured by ultrasound to predict difficult airways

Zhenwei Zheng et al.

Summary: The study showed that using ultrasound to measure midsagittal tongue CSA can help predict the risk of difficult laryngoscopy and difficult intubation. Midsagittal tongue CSA has certain sensitivity and specificity in predicting difficult airways.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Neurophysiological models of phantom limb pain: what can be learnt

Giovanni Di Pino et al.

Summary: Phantom Limb Pain (PLP) is a painful sensation perceived in the lost limb, caused by structural and functional changes in the nervous system. Various pathogenetic models include the neuroma model, peripheral-origin models, and the cortical remapping model, among others. Relief of PLP may involve interactions between motor and somatosensory circuits and mechanisms of limb replacement.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Risk factors for difficult Laryngeal Mask Airway LMA-Supreme™ (LMAS) placement in adults: a multicentric prospective observational study in an Italian population

Alessandro Di Filippo et al.

Summary: A study on 432 Italian adult patients found that Mallampati grading, inter-incisor distance, reduced neck mobility, and administration of neuromuscular blocking agents were significantly associated with difficult placement of the Laryngeal Mask Airway LMA-Supreme.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Superficial cervical plexus block alone or combined with interscalene brachial plexus block in surgery for clavicle fractures: a randomized clinical trial

Mohamed S. Abdelghany et al.

Summary: In patients undergoing internal fixation of clavicular fracture, the perioperative analgesic effect of superficial cervical plexus block alone is equally effective to its use in combination with interscalene block, with no significant impact on postoperative pain control.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Impact of the pericapsular nerve group (PENG) block on postoperative analgesia and functional recovery following total hip arthroplasty: a randomised, observer-masked, controlled trial

G. Pascarella et al.

Summary: The pericapsular nerve group block significantly reduced pain and opioid consumption, improved hip motion range, and promoted early functional recovery in patients undergoing total hip arthroplasty.

ANAESTHESIA (2021)

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Editorial Material Anesthesiology

It is time to prove that regional anesthesia can be a game changer in the recovery after surgery in children

Cassandra Poirier et al.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Predicting difficult spinal anesthesia: development of a neuraxial block assessment score

Romualdo Del Buono et al.

Summary: This study proposed a simple clinical scoring system to predict the difficulty of lumbar spinal anesthesia, finding that the combination of multiple factors increased the chance of a second skin puncture success.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Causes of arterial hypotension during anesthetic induction with propofol investigated with perfusion index and ClearSight™ in young and elderly patients

Masato Nakasuji et al.

Summary: The main mechanism of hypotension during anesthetic induction in elderly patients is a decrease in cardiac output, while in younger patients it is primarily a reduction of systemic vascular resistance.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

A randomized clinical trial comparing six techniques of postoperative analgesia for elective total hip arthroplasty under subarachnoid anesthesia with opioids

Jose R. Ortiz-Gomez et al.

Summary: The study showed that infra-inguinal FICB and LFCNB, combined with a multimodal analgesic approach, did not improve immediate postoperative analgesia for total hip arthroplasty in the hospital setting. Further investigation is needed to determine the role of peripheral blocks in postoperative pain treatment protocols.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Updates on neurologic complications in pediatric regional anesthesia

Yeona Chun et al.

Summary: While there are risks of neurological injury, studies have shown that pediatric regional anesthesia is as safe as in adult patients. Large datasets confirm the effectiveness and safety of regional anesthesia in pediatric patients, highlighting the need for further research on neurological complications.

MINERVA ANESTESIOLOGICA (2021)

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Review Pharmacology & Pharmacy

Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent

Gavin J. Kilpatrick

Summary: The program aimed to identify novel intravenous sedatives with short and predictable duration of action, leading to the discovery of remimazolam. However, slow development progress due to resource limitations, the compound has been approved for various uses in different countries. Remimazolam differentiates itself from other intravenous agents with its unique pharmacological profile and low liability for adverse effects.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Anesthesiology

Volatile anesthetics versus intravenous anesthetics for noncardiac thoracic surgery: a systematic review and meta-analysis

Yuchao Fan et al.

Summary: The meta-analysis found that volatile anesthetics reduce postoperative complications and the length of stay in the intensive care unit for lung surgery, and also lower airway inflammation levels in patients undergoing noncardiac thoracic surgery.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Prospective observational study evaluating the C-MAC Video Stylet for awake tracheal intubation: a single-center study

Sabine Nabecker et al.

Summary: The study evaluated the feasibility of awake orotracheal intubations using the C-MAC Video Stylet, showing a high success rate with minimal complaints of sore throat and minor injuries on the first postoperative day.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

The opioid sparing effect of erector spinae plane block for various surgeries: a meta-analysis of randomized-controlled trials

Andrea Fanelli et al.

Summary: The erector spinae plane block (ESPB) shows effectiveness in reducing opioid consumption in breast, thoracic, and vertebral surgeries; it outperforms alternative blocks in some surgeries; ESPB could be a valuable addition to multimodal analgesic regimens for various surgeries.

MINERVA ANESTESIOLOGICA (2021)

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Review Anesthesiology

Postoperative pain after intrathecal analgesia in laparoscopic liver resection: a retrospective chart review

April Y. Liu et al.

Summary: This study investigated the efficacy of postoperative pain management in patients undergoing laparoscopic liver resections, with results showing that intrathecal analgesia (IA) has the potential to reduce postoperative opioid use and appears to be safe and effective in this setting.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Update on the SedLine® algorithm for calculating the Patient State Index of older individuals during general anesthesia: a randomized controlled trial

Shinju Obara et al.

Summary: The study showed that the incidence of AHPSi decreased with the use of the updated version of the SedLine(R) algorithm. Lower TP values and the use of the old algorithm had a significant effect on increasing PSi values.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Comparison of arterial blood pressure and cardiac index-based hemodynamic management on cognitive function in elderly patients undergoing spinal surgery: a randomized clinical trial

Esra Saka et al.

Summary: In this study, it was found that hemodynamic management based on Cardiac Index (CI) provided better postoperative cognitive function compared to MAP-based management, along with improved intraoperative rScO(2) levels.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

The role of artificial intelligence in surgical patient perioperative management

Elena G. Bignami et al.

Summary: Perioperative medicine is a patient-centered clinical practice that involves studying and planning each phase of surgery to optimize patient management, with AI playing a key role in assisting human minds in decision-making.

MINERVA ANESTESIOLOGICA (2021)

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Article Anesthesiology

Determination of the initial minimum effective dose of 0.5% bupivacaine with 20 μg of fentanyl for an operative fixation of fractured neck of femur: a prospective, observational trial

Tomas Hitka et al.

Summary: This study shows that the use of a spinal catheter allows for precise titration of local anesthetic, reducing the initial intrathecal dose of 0.5% isobaric bupivacaine when combined with intrathecal opioids.

MINERVA ANESTESIOLOGICA (2021)

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Article Surgery

Utilizing Machine Learning Methods for Preoperative Prediction of Postsurgical Mortality and Intensive Care Unit Admission

Calvin J. Chiew et al.

ANNALS OF SURGERY (2020)

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Article Anesthesiology

Protective and Risk Factors for Phantom Limb Pain and Residual Limb Pain Severity

Marionna Munger et al.

PAIN PRACTICE (2020)

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Letter Anesthesiology

Breast surgery analgesia: another perspective for PROSPECT guidelines

F. Costa et al.

ANAESTHESIA (2020)

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Review Anesthesiology

Frailty for Perioperative Clinicians: A Narrative Review

Daniel I. McIsaac et al.

ANESTHESIA AND ANALGESIA (2020)

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Review Anesthesiology

The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises

Srinivasa N. Raja et al.

PAIN (2020)

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Article Anesthesiology

Continuous PENG block for hip fracture: a case series

Romualdo Del Buono et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2020)

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Article Medicine, General & Internal

Behavioral Factors Related to the Incidence of Frailty in Older Adults

Hiroyuki Shimada et al.

JOURNAL OF CLINICAL MEDICINE (2020)

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Letter Anesthesiology

Could US-guided PENG block pass the ICU door? First reported case in a multiple-fracture ICU patient

Pierfrancesco Fusco et al.

MINERVA ANESTESIOLOGICA (2020)

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Article Anesthesiology

Oxygen Reserve Index: Validation of a New Variable

Jaap Jan Vos et al.

ANESTHESIA AND ANALGESIA (2019)

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Review Anesthesiology

Intra-operative analgesia with remifentanil vs. dexmedetomidine: a systematic review and meta-analysis with trial sequential analysis

S. Grape et al.

ANAESTHESIA (2019)

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Review Anesthesiology

Objective monitoring of nociception: a review of current commercial solutions

Thomas Ledowski

BRITISH JOURNAL OF ANAESTHESIA (2019)

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Review Anesthesiology

Effect of Adding Dexmedetomidine to Local Anesthetic Agents for Transversus Abdominis Plane Block A Meta-analysis

Prannal Bansal et al.

CLINICAL JOURNAL OF PAIN (2019)

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Article Cardiac & Cardiovascular Systems

Pathophysiology, diagnosis and management of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy

Johann Bauersachs et al.

EUROPEAN JOURNAL OF HEART FAILURE (2019)

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Article Clinical Neurology

Opioid-Induced Tolerance and Hyperalgesia

Sebastiano Mercadante et al.

CNS DRUGS (2019)

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Article Anesthesiology

y General principles of regional anaesthesia in children

F. Merella et al.

BJA EDUCATION (2019)

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Review Anesthesiology

Postoperative acute pain challenges in patients with cancer

Juan P. Cata et al.

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY (2019)

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Letter Anesthesiology

Reply to Dr Nielsen: Pericapsular Nerve Group (PENG) block for hip fracture

Philip W. H. Peng et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2019)

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Review Anesthesiology

Perioperative Noninvasive Blood Pressure Monitoring

Kai Kuck et al.

ANESTHESIA AND ANALGESIA (2018)

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Article Anesthesiology

Guidelines for the management of tracheal intubation in critically ill adults

A. Higgs et al.

BRITISH JOURNAL OF ANAESTHESIA (2018)

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Review Medicine, General & Internal

Supraglottic airway devices: current and future uses

Lloyd E. Kwanten et al.

BRITISH JOURNAL OF HOSPITAL MEDICINE (2018)

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Review Cardiac & Cardiovascular Systems

NEW Prehabilitation: A 3-Way Approach to Improve Postoperative Survival and Health-Related Quality of Life in Cardiac Surgery Patients

Rakesh C. Arora et al.

CANADIAN JOURNAL OF CARDIOLOGY (2018)

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Review Anesthesiology

Does goal-directed haemodynamic and fluid therapy improve peri-operative outcomes? A systematic review and meta-analysis

Matthew A. Chong et al.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY (2018)

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Review Anesthesiology

Enhanced recovery after surgery in children: Promising, evidence-based multidisciplinary care

Kyle O. Rove et al.

PEDIATRIC ANESTHESIA (2018)

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Article Clinical Neurology

Immune function after major surgical interventions: the effect of postoperative pain treatment

Giada Amodeo et al.

JOURNAL OF PAIN RESEARCH (2018)

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Article Anesthesiology

Pericapsular Nerve Group (PENG) Block for Hip Fracture

Laura Giron-Arango et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2018)

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Article Anesthesiology

Multimodal General Anesthesia: Theory and Practice

Emery N. Brown et al.

ANESTHESIA AND ANALGESIA (2018)

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Editorial Material Clinical Neurology

From SIMPAR to CIMPARC: the evolution of international pain research and management

Massimo Allegri et al.

JOURNAL OF PAIN RESEARCH (2018)

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Article Anesthesiology

Prediction of difficult mask ventilation using a systematic assessment of risk factors vs. existing practice - a cluster randomised clinical trial in 94,006 patients

A. K. Norskov et al.

ANAESTHESIA (2017)

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Article Emergency Medicine

EFFECT OF CRICOID PRESSURE ON THE INSERTION EFFICACY OF SIX SUPRAGLOTTIC DEVICES: A CROSSOVER RANDOMIZED SIMULATION TRIAL

Fumihiro Ohchi et al.

JOURNAL OF EMERGENCY MEDICINE (2017)

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Review Cell Biology

Anesthetic considerations for patients with acute cervical spinal cord injury

Fang-ping Bao et al.

NEURAL REGENERATION RESEARCH (2017)

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Review Anesthesiology

Investigating the Efficacy of Dexmedetomidine as an Adjuvant to Local Anesthesia in Brachial Plexus Block A Systematic Review and Meta-Analysis of 18 Randomized Controlled Trials

Nasir Hussain et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2017)

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Review Anesthesiology

Do we feel pain during anesthesia? A critical review on surgery-evoked circulatory changes and pain perception

A. Cividjian et al.

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY (2017)

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Article Anesthesiology

Opioid-free anesthesia opioid side effects: Tolerance and hyperalgesia

Patricia Lavand'homme et al.

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY (2017)

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Article Anesthesiology

Postoperative pulmonary complications, pulmonary and systemic inflammatory responses after lung resection surgery with prolonged one-lung ventilation. Randomized controlled trial comparing intravenous and inhalational anaesthesia

F. de la Gala et al.

BRITISH JOURNAL OF ANAESTHESIA (2017)

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Article Neurosciences

Postoperative pain-from mechanisms to treatment

Esther M. Pogatzki-Zahn et al.

PAIN REPORTS (2017)

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Article Medicine, General & Internal

Multimodal Treatment of Chronic Pain

Rebecca Dale et al.

MEDICAL CLINICS OF NORTH AMERICA (2016)

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Review Surgery

Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations

Emmanuel Melloul et al.

WORLD JOURNAL OF SURGERY (2016)

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Review Emergency Medicine

The endothelial glycocalyx and its disruption, protection and regeneration: a narrative review

Ulf Schott et al.

SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE (2016)

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Review Anesthesiology

A systematic review of sugammadex vs neostigmine for reversal of neuromuscular blockade

A. Abad-Gurumeta et al.

ANAESTHESIA (2015)

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Article Anesthesiology

The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia

P. L. Purdon et al.

BRITISH JOURNAL OF ANAESTHESIA (2015)

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Article Anesthesiology

Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults

C. Frerk et al.

BRITISH JOURNAL OF ANAESTHESIA (2015)

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Article Anesthesiology

Quadratus lumborum block for postoperative pain after caesarean section A randomised controlled trial

Rafael Blanco et al.

EUROPEAN JOURNAL OF ANAESTHESIOLOGY (2015)

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Article Surgery

Effects of dexmedetomidine on patients undergoing radical gastrectomy

Yulan Wang et al.

JOURNAL OF SURGICAL RESEARCH (2015)

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Article Medicine, General & Internal

Macroeconomic implications of population ageing and selected policy responses

David E. Bloom et al.

LANCET (2015)

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Review Biotechnology & Applied Microbiology

Impact of Volatile Anesthetics on Oxidative Stress and Inflammation

Yoon-Mi Lee et al.

BIOMED RESEARCH INTERNATIONAL (2015)

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Article Anesthesiology

Diagnostic accuracy of anaesthesiologists' prediction of difficult airway management in daily clinical practice: a cohort study of 188 064 patients registered in the Danish Anaesthesia Database

A. K. Norskov et al.

ANAESTHESIA (2015)

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Article Anesthesiology

Analgesia for Clavicular Fracture and Surgery A Call for Evidence

De Q. H. Tran et al.

REGIONAL ANESTHESIA AND PAIN MEDICINE (2013)

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Article Anesthesiology

Anesthetic-induced Improvement of the Inflammatory Response to One-lung Ventilation

Elisena De Conno et al.

ANESTHESIOLOGY (2009)

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Article Anesthesiology

Cricoid pressure prevents placement of the laryngeal tube and laryngeal tube-suction II

T. Asai et al.

BRITISH JOURNAL OF ANAESTHESIA (2007)

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Article Anesthesiology

Documentation on the anesthetic record: correlation with clinically important variables

Michael J. Tessler et al.

CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE (2006)

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Article Anesthesiology

Reflex pupillary dilatation in response to skin incision and alfentanil in children anaesthetized with sevoflurane: a more sensitive measure of noxious stimulation than the commonly used variables

I Constant et al.

BRITISH JOURNAL OF ANAESTHESIA (2006)

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Review Medicine, General & Internal

Perioperative cardiac events in patients undergoing noncardiac surgery: a review of the magnitude of the problem, the pathophysiology of the events and methods to estimate and communicate risk

PJ Devereaux et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2005)

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Article Anesthesiology

Development of a difficulty score for spinal anaesthesia

MM Atallah et al.

BRITISH JOURNAL OF ANAESTHESIA (2004)

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Article Anesthesiology

Chronic pain following Caesarean section

L Nikolajsen et al.

ACTA ANAESTHESIOLOGICA SCANDINAVICA (2004)

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