期刊
MICROSCOPY RESEARCH AND TECHNIQUE
卷 85, 期 7, 页码 2651-2658出版社
WILEY
DOI: 10.1002/jemt.24119
关键词
endostyle; immune cells; Styela plicata; TLR2; VIP; WGA
资金
- Universita degli Studi di Messina
The endostyle is the first component of the ascidian digestive tract, divided into nine zones with distinct cells and functions. Immunohistochemical investigation revealed the presence of immune cells in the endostyle of Styela plicata, indicating highly conserved innate immune mechanisms in the chordates' phylogeny.
The endostyle is the first component of the ascidian digestive tract, it is shaped like a through and is located in the pharynx's ventral wall. This organ is divided longitudinally into nine zones that are parallel to each other. Each zone's cells are physically and functionally distinct. Support elements are found in zones 1, 3, and 5, while mucoproteins secreting elements related to the filtering function are found in zones 2, 4, and 6. Zones 7, 8, and 9, which are located in the lateral dorsal section of the endostyle, include cells with high iodine and peroxidase concentrations. Immunohistochemical technique using the following antibodies, Toll-like receptor 2 (TLR-2) and vasoactive intestinal peptide (VIP), and lectin histochemistry (WGA-wheat-germagglutinin), were used in this investigation to define immune cells in the endostyle of Styela plicata (Lesueur, 1823). Our results demonstrate the presence of immune cells in the endostyle of S. plicata, highlighting that innate immune mechanisms are highly conserved in the phylogeny of the chordates.
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