A highly selective and sensitive electrochemical sensor based on graphene oxide and molecularly imprinted polymer magnetic nanocomposite for patulin determination

Since a high concentration of patulin is caused cytotoxic, the detection of a novel approach for patulin determination plays an important guiding role in the research and development of new control technologies. For the first time, we have developed a novel sensor using a glassy carbon electrode modified by a composite consisting of ionic liquid-based molecularly imprinted polymer (MIP) and magnetic nanoparticles/graphene oxide (Fe3O4/GO) for the determination of patulin toxin using square wave voltammetry technique. The nanostructures were prepared and characterized with scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and energy dispersive X-ray spectroscopy (EDX) techniques. Several experimental parameters affecting the patulin determination, such as scan rate, the type, and pH of buffer solution, were studied and optimized. Under the optimized conditions, a linear range of 0.001 nM 250.0 nM, a limit of quantification of 0.001 nM and a limit of detection of 3.33x10(-4) nM was obtained. The RSDs for 1.0 nM and 250.0 nM patulin were calculate 1.65 % and 0.83%, respectively. The MIP/ Fe3O4/GO/GCE was successfully applied to detect patulin toxin in apple juice real samples.

Automated summary

A novel sensor was developed for the determination of patulin toxin using a glassy carbon electrode modified with a composite material, providing high sensitivity and accuracy.