期刊
MICROBIOLOGY-SGM
卷 168, 期 4, 页码 -出版社
MICROBIOLOGY SOC
DOI: 10.1099/mic.0.001159
关键词
lipopolysaccharide; antimicrobial peptides; outer membrane; permeability; intracellular survival; infection
类别
资金
- Biotechnology and Biological Sciences Research Council [BB/T005807/1, BB/S006281/1]
- US Cystic Fibrosis Foundation (USA) [VALVAN19G0]
- European Training Networks (BactiVax, MSCA-ITN)
Lipopolysaccharide (LPS) is a characteristic molecule of the outer leaflet of the Gram-negative bacterial outer membrane, consisting of lipid A, core oligosaccharide, and O antigen. It plays an important role in reducing the permeability of antibiotics, toxic cationic metals, and antimicrobial peptides, and modulates innate immune responses.
The lipopolysaccharide (LPS) is a characteristic molecule of the outer leaflet of the Gram-negative bacterial outer membrane, which consists of lipid A, core oligosaccharide, and O antigen. The lipid A is embedded in outer membrane and provides an efficient permeability barrier, which is particularly important to reduce the permeability of antibiotics, toxic cationic metals, and antimicrobial peptides. LPS, an important modulator of innate immune responses ranging from localized inflammation to disseminated sepsis, displays a high level of structural and functional heterogeneity, which arise due to regulated differences in the acylation of the lipid A and the incorporation of non-stoichiometric modifications in lipid A and the core oligosaccharide. This review focuses on the current mechanistic understanding of the synthesis and assembly of the lipid A molecule and its most salient non-stoichiometric modifications.
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