期刊
MICROBIAL PATHOGENESIS
卷 167, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2022.105590
关键词
Zebrafish; Mycobacteria; Angiogenesis; Vascular permeability; Platelet
资金
- New South Wales Ministry of Health [H18/31086]
- University of Sydney [G197581]
- Australian National Health and Medical Research Council [APP1153493]
Mycobacterium abscessus infections are difficult to treat due to complex antibiotic resistance. This study used a zebrafish-M. abscessus model to identify potential host-directed therapies, finding that anti-angiogenic and vascular normalizing therapies were effective against the infection.
Mycobacterium abscessus infections are of increasing global prevalence and are often difficult to treat due to complex antibiotic resistance profiles. While there are similarities between the pathogenesis of M. abscessus and tuberculous mycobacteria, including granuloma formation and stromal remodelling, there are distinct molecular differences at the host-pathogen interface. Here we have used a zebrafish-M. abscessus model and host-directed therapies that were previously identified in the zebrafish-M. marinum model to identify potential host-directed therapies against M. abscessus infection. We find efficacy of anti-angiogenic and vascular normalizing therapies against rough M. abscessus infection, but no effect of anti-platelet drugs.
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