4.5 Review

Miller Fisher syndrome after COVID-19 vaccination: Case report and review of literature

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A systematic review of cases of CNS demyelination following COVID-19 vaccination

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Summary: This study conducted a systematic review on CNS demyelination cases following COVID-19 vaccination and identified a total of 32 cases. Most cases occurred after the first dose of the vaccine, with half of them having a history of immune-mediated diseases. Treatment included high dose methylprednisolone, PLEX, IVIg, or a combination of those, with favorable outcomes observed in the majority of cases, suggesting the need for long-term post-marketing surveillance.

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Summary: This case report describes the first instance of Guillain-Barre Syndrome following the Pfizer COVID-19 vaccine, highlighting the potential for neurological complications. Treatment included intravenous immunoglobulin administration and regular monitoring of lung function, but more research and attention are needed to fully understand the risk of neurological complications from COVID-19 vaccines.

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Case of Guillain-Barre syndrome following COVID-19 vaccine

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Summary: This case report presents a instance of Guillain-Barre syndrome occurring after receiving the Oxford/AstraZeneca COVID-19 vaccine. While a direct link could not be established, it emphasizes the need to consider this issue when evaluating cases of GBS.

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Guillain-Barre syndrome after COVID-19 vaccination

Norma McKean et al.

Summary: The correlation between COVID-19 infection/vaccination and GBS remains unclear, requiring ongoing assessment of risks. The specific presentation of bifacial weakness as a symptom of GBS may be related to COVID-19 vaccination.

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Miller Fisher syndrome following BNT162b2 mRNA coronavirus 2019 vaccination

Yamato Nishiguchi et al.

Summary: This case report describes a 71-year-old man who developed Miller Fisher syndrome (MFS) after receiving the BNT162b2 mRNA COVID-19 vaccine. More research is needed to establish the association between MFS and COVID-19 vaccines.

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Miller Fisher syndrome associated with COVID-19: an up-to-date systematic review

Zheng Li et al.

Summary: From the first report of COVID-19 to October 8, 2020, there were 7 cases of Miller Fisher syndrome (MFS) associated with COVID-19, mainly from Europe, with symptoms including sensory abnormalities, ataxia, blurred vision, etc. More research is needed to establish the epidemiological linkage.

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Guillain-Barre Syndrome following ChAdOx1-S/nCoV-19 Vaccine

Boby Maramattom et al.

Summary: In three districts of Kerala, India, around 1.5 million individuals have been vaccinated with COVID-19 vaccines, with over 80% receiving the ChAdOx1-S/nCoV-19 vaccine. Seven cases of Guillain-Barre syndrome (GBS) have been observed within this vaccinated population, with a frequency 1.4- to 10-fold higher than expected.

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Miller-Fisher Syndrome and Guillain-Barre Syndrome overlap syndrome in a patient post Oxford-AstraZeneca SARS-CoV-2 vaccination

Yew Li Dang et al.

Summary: This case highlights the importance of recognizing rare neurological complications post-vaccination, particularly GBS and MFS syndrome overlap, which have potential implications for patient counselling and monitoring.

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Miller-Fisher syndrome after SARS-CoV-2 infection

J. A. Reyes-Bueno et al.

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Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barre Syndrome in Brazil

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LANCET (2016)

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Guillain-Barre and Miller Fisher syndromes-new diagnostic classification

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Fisher syndrome: clinical features, immunopathogenesis and management

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Miller Fisher's Syndrome

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