Quinoline: Synthesis to Application

This review aims to provide a comprehensive report on the quinoline ring with respect to its synthesis, reactivity, and therapeutic values. The reactivity of quinoline for the metal, electrophile, and other reactive counterparts defines the shape of the quinoline pharmacophore, which is an important part of this report; moreover, its spectroscopic characteristics have been included herein with suitable illustration. The quinoline and its derivatives have been presented as well as the general synthetic approaches along with the new developments in the catalytic system; the relevant information is also summarized under the various separate activity classes. The synthesis of heterocyclic scaffolds has been a concern for scientists, so herein we have tried to include the synthetic parameters of quinoline with regard to the important pharmacological aspects.

Automated summary

This review provides a comprehensive report on the synthesis, reactivity, and therapeutic values of the quinoline ring. The reactivity of quinoline with metal, electrophile, and other reactive counterparts shapes the quinoline pharmacophore, which is an important part of this report. The spectroscopic characteristics of quinoline are also discussed with suitable illustrations. Additionally, the synthesis of quinoline and its derivatives, along with the new developments in catalytic systems, are presented, and the relevant information is summarized under various activity classes. The synthetic parameters of quinoline with regard to important pharmacological aspects are highlighted.