4.5 Article

Pan-tissue methylation aging clock: Recalibrated and a method to analyze and interpret the selected features

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Cell Biology

Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans

Paola Sebastiani et al.

Summary: Using samples from the New England Centenarian Study, researchers characterized the serum proteome of centenarians, their offspring, and age-matched controls. They identified protein signatures associated with longer survival in centenarians and younger individuals and found similarities in aging markers between centenarians and short-lived cohorts. The study provides specific circulating biomarkers of healthy aging and longevity, suggesting potential mechanisms to prolong health and support longevity.

AGING CELL (2021)

Article Cardiac & Cardiovascular Systems

Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure

Mark E. Pepin et al.

Summary: This study found a bimodal signature of cardiac DNA methylation in heart failure, corresponding to racial differences in all-cause mortality following mechanical circulatory support. Racial differences in promoter methylation disproportionately affect metabolic signaling pathways. Socioeconomic factors are associated with racial differences in the cardiac methylome among men with end-stage heart failure.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Molecular Signatures of Idiopathic Pulmonary Fibrosis

Iain R. Konigsberg et al.

Summary: This study integrated coding and noncoding transcriptomes, DNA methylomes, and proteomes to identify molecules and pathways associated with idiopathic pulmonary fibrosis (IPF). Analysis of data from 24 IPF subjects and 14 control subjects identified differentially expressed transcripts, abundant proteins, methylated regions, and long noncoding RNAs. The results demonstrated novel molecular relationships in IPF using a system biology approach.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2021)

Article Geriatrics & Gerontology

DeepMAge: A Methylation Aging Clock Developed with Deep Learning

Fedor Galkin et al.

Summary: DNA methylation aging clocks have become an invaluable tool in biogerontology research, with deep learning showing promise as an accurate method for predicting age. The newly presented DeepMAge clock demonstrates biological relevance by assigning higher predicted age to individuals with certain health-related conditions.

AGING AND DISEASE (2021)

Review Cell Biology

Measuring biological aging in humans: A quest

Luigi Ferrucci et al.

AGING CELL (2020)

Article Biotechnology & Applied Microbiology

A multidimensional systems biology analysis of cellular senescence in aging and disease

Roberto A. Avelar et al.

GENOME BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Epigenetic changes during aging and their reprogramming potential

Alice E. Kane et al.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2019)

Article Biochemistry & Molecular Biology

g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update)

Uku Raudvere et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Biochemistry & Molecular Biology

WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs

Yuxing Liao et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Biochemistry & Molecular Biology

Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions

Abel Soto-Gamez et al.

JOURNAL OF MOLECULAR BIOLOGY (2019)

Article Cell Biology

An epigenetic biomarker of aging for lifespan and healthspan

Morgan E. Levine et al.

AGING-US (2018)

Review Genetics & Heredity

DNA methylation-based biomarkers and the epigenetic clock theory of ageing

Steve Horvath et al.

NATURE REVIEWS GENETICS (2018)

Article Biochemical Research Methods

Preprocessing, normalization and integration of the Illumina HumanMethylationEPIC array with minfi

Jean-Philippe Fortin et al.

BIOINFORMATICS (2017)

Article Biochemistry & Molecular Biology

Accumulation of apoptosis-insensitive human bone marrow-mesenchymal stromal cells after long-term expansion

Sin-Gu Jeong et al.

CELL BIOCHEMISTRY AND FUNCTION (2016)

Article Biochemistry & Molecular Biology

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

Gregory Hannum et al.

MOLECULAR CELL (2013)

Article Biotechnology & Applied Microbiology

DNA methylation age of human tissues and cell types

Steve Horvath

GENOME BIOLOGY (2013)

Article Cell Biology

Methylation of ELOVL2 gene as a new epigenetic marker of age

Paolo Garagnani et al.

AGING CELL (2012)

Review Cell Biology

Adult mesenchymal stem cells for tissue engineering versus regenerative medicine

Arnold I. Caplan

JOURNAL OF CELLULAR PHYSIOLOGY (2007)

Article Biochemistry & Molecular Biology

GenAge: a genomic and proteomic network map of human ageing

JP de Magalhaes et al.

FEBS LETTERS (2004)