4.6 Review

Skeletal Aging

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Review Endocrinology & Metabolism

Secondary Osteoporosis

Peter R. Ebeling et al.

Summary: Osteoporosis is a global public health problem with high prevalence rates among postmenopausal women, premenopausal women, and men. Identifying secondary causes of osteoporosis is crucial as treatment often involves addressing the underlying condition. Screening is recommended for all osteoporosis patients, with advanced investigations necessary for certain groups. The response to conventional therapy may be insufficient if the underlying condition is not recognized and treated. Bone densitometry can underestimate or overestimate fracture risk in certain chronic diseases. Tools such as FRAX and trabecular bone score provide additional information on fracture risk in secondary osteoporosis.

ENDOCRINE REVIEWS (2022)

Review Pharmacology & Pharmacy

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Paul D. Robbins et al.

Summary: Senescence is a signaling mechanism activated in stressed cells to prevent proliferation of damaged cells, leading to chronic sterile inflammation and age-related diseases. Senescent cells accumulate with age and in diseased anatomical sites, making them a logical therapeutic target. Senotherapeutics, a new class of drugs, selectively kill senescent cells or suppress their disease-causing phenotypes, showing promising results in preclinical studies and clinical trials.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

Article Endocrinology & Metabolism

Teriparatide Did Not Increase Adult Osteosarcoma Incidence in a 15-Year US Postmarketing Surveillance Study

Alicia Gilsenan et al.

Summary: The Osteosarcoma Surveillance Study in the US from 2003 to 2016 did not find a significant association between teriparatide treatment and osteosarcoma, with the incidence rate aligning with the background rate. Interviewed patients had similar characteristics to non-interviewed patients, and the prevalence of risk factors like radiation history and Paget's disease was low in the osteosarcoma cohort.

JOURNAL OF BONE AND MINERAL RESEARCH (2021)

Review Geriatrics & Gerontology

The prevention of osteoporosis and sarcopenia in older adults

Patrick P. Coll et al.

Summary: Osteoporosis and sarcopenia are common in older adults and can lead to issues such as frailty and disability. Prevention strategies include recommended screening and treatment to address these conditions.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2021)

Article Multidisciplinary Sciences

Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling

Charles A. Schurman et al.

Summary: Skeletal fragility in the elderly is not solely due to bone mass loss, with osteocytes playing a key role in bone aging. The degeneration of the lacunocanalicular network may lead to compromised mechanostimulation of osteocytes, highlighting them as potential targets for age-related therapeutic interventions to improve bone health.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Geriatrics & Gerontology

Vitamin D supplementation and risk of falling: outcomes from the randomized, placebo-controlled D-Health Trial

Mary Waterhouse et al.

Summary: This study found that monthly high-dose vitamin D supplementation did not reduce the risk of falls, and may potentially increase the risk of falling in individuals with normal BMI. Further investigation is needed to better understand the impact of vitamin D supplementation on falls risk in different populations.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

Article Endocrinology & Metabolism

Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence?

Jad G. Sfeir et al.

Summary: With the aging population, there is an increasing trend in patients aged 85 years or older seeking interventions to protect their musculoskeletal health. Osteoporosis in the elderly presents unique challenges, with factors like multimorbidity, frailty, falls, polypharmacy influencing fracture prevention approaches. Studies mainly focus on pharmacologic interventions for postmenopausal women, with limited evidence for the oldest old men and women who are also at risk for adverse events and mortality.

JBMR PLUS (2021)

Article Endocrinology & Metabolism

Effects of Zoledronate on Cancer, Cardiac Events, and Mortality in Osteopenic Older Women

Ian R. Reid et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Article Endocrinology & Metabolism

A Pooled Analysis of Fall Incidence From Placebo-Controlled Trials of Denosumab

Pojchong Chotiyarnwong et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Article Endocrinology & Metabolism

Targeted Reduction of Senescent Cell Burden Alleviates Focal Radiotherapy-Related Bone Loss

Abhishek Chandra et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2020)

Review Endocrinology & Metabolism

The role of cellular senescence in ageing and endocrine disease

Sundeep Khosla et al.

NATURE REVIEWS ENDOCRINOLOGY (2020)

Review Endocrinology & Metabolism

Osteocyte Cellular Senescence

Joshua N. Farr et al.

CURRENT OSTEOPOROSIS REPORTS (2020)

Review Medical Laboratory Technology

Cellular senescence in age-related disorders

Japneet Kaur et al.

TRANSLATIONAL RESEARCH (2020)

Article Endocrinology & Metabolism

Cellular senescence in bone

Joshua N. Farr et al.

Letter Geriatrics & Gerontology

EFFECT OF DENOSUMAB ON FALLS, MUSCLE STRENGTH, AND FUNCTION IN COMMUNITY-DWELLING OLDER ADULTS

Steven Phu et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2019)

Article Geriatrics & Gerontology

Fracture Risk Assessment in Long-term Care (FRAiL): Development and Validation of a Prediction Model

Sarah D. Berry et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2018)

Article Endocrinology & Metabolism

Significant bone loss after stopping long-term denosumab treatment: a post FREEDOM study

M. B. Zanchetta et al.

OSTEOPOROSIS INTERNATIONAL (2018)

Review Medicine, General & Internal

Interventions to Prevent Falls in Older Adults Updated Evidence Report and Systematic Review for the US Preventive Services Task Force

Janelle M. Guirguis-Blake et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2018)

Article Endocrinology & Metabolism

A Phase III Randomized Placebo-Controlled Trial to Evaluate Efficacy and Safety of Romosozumab in Men With Osteoporosis

E. Michael Lewiecki et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Obstetrics & Gynecology

Effects of abaloparatide on bone mineral density and risk of fracture in postmenopausal women aged 80 years or older with osteoporosis

Michael R. McClung et al.

MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY (2018)

Article Biochemistry & Molecular Biology

Senolytics improve physical function and increase lifespan in old age

Ming Xu et al.

NATURE MEDICINE (2018)

Review Environmental Sciences

Exercise Early and Often: Effects of Physical Activity and Exercise on Women's Bone Health

Karen L. Troy et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2018)

Review Endocrinology & Metabolism

The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging

Joshua N. Farr et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2018)

Article Geriatrics & Gerontology

International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management

E. Dent et al.

JOURNAL OF NUTRITION HEALTH & AGING (2018)

Article Geriatrics & Gerontology

High-Dose Monthly Vitamin D for Prevention of Acute Respiratory Infection in Older Long-Term Care Residents: A Randomized Clinical Trial

Adit A. Ginde et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2017)

Article Medicine, Research & Experimental

Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis

Kyu Sang Joeng et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr et al.

NATURE MEDICINE (2017)

Article Medicine, General & Internal

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

Kenneth G. Saag et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Environmental Sciences

The Effect of Taichi Practice on Attenuating Bone Mineral Density Loss: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Liye Zou et al.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2017)

Review Endocrinology & Metabolism

Osteoporosis treatment: recent developments and ongoing challenges

Sundeep Khosla et al.

LANCET DIABETES & ENDOCRINOLOGY (2017)

Article Cell Biology

Degeneration of the osteocyte network in the C57BL/6 mouse model of aging

LeAnn M. Tiede-Lewis et al.

AGING-US (2017)

Article Medicine, General & Internal

Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis A Randomized Clinical Trial

Paul D. Miller et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Endocrinology & Metabolism

Identification of Senescent Cells in the Bone Microenvironment

Joshua N. Farr et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2016)

Article Medicine, General & Internal

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

F. Cosman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Endocrinology & Metabolism

Usefulness of daily teriparatide treatment in elderly patients over 80 years of age

R. Niimi et al.

OSTEOPOROSIS INTERNATIONAL (2016)

Article Medicine, General & Internal

Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline A Randomized Clinical Trial

Heike A. Bischoff-Ferrari et al.

JAMA INTERNAL MEDICINE (2016)

Article Endocrinology & Metabolism

Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model

Laura E. Wright et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2015)

Article Medicine, General & Internal

Efficacy and Safety of Single-Dose Zoledronic Acid for Osteoporosis in Frail Elderly Women A Randomized Clinical Trial

Susan L. Greenspan et al.

JAMA INTERNAL MEDICINE (2015)

Article Medicine, General & Internal

Exercise and Vitamin Din Fall Prevention Among Older Women A Randomized Clinical Trial

Kirsti Uusi-Rasi et al.

JAMA INTERNAL MEDICINE (2015)

Review Endocrinology & Metabolism

The bone-fat interface: basic and clinical implications of marrow adiposity

Maureen J. Devlin et al.

LANCET DIABETES & ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

In Vivo Assessment of Bone Quality in Postmenopausal Women With Type 2 Diabetes

Joshua N. Farr et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2014)

Article Geriatrics & Gerontology

Grip Strength Cutpoints for the Identification of Clinically Relevant Weakness

Dawn E. Alley et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Article Endocrinology & Metabolism

Clinician's Guide to Prevention and Treatment of Osteoporosis

F. Cosman et al.

OSTEOPOROSIS INTERNATIONAL (2014)

Article Multidisciplinary Sciences

Grip Strength across the Life Course: Normative Data from Twelve British Studies

Richard M. Dodds et al.

PLOS ONE (2014)

Review Endocrinology & Metabolism

Glucocorticoids and osteocyte autophagy

Wei Yao et al.

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Article Biochemistry & Molecular Biology

Suppression of Autophagy in Osteocytes Mimics Skeletal Aging

Melda Onal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Endocrinology & Metabolism

Vertebral Bone Marrow Fat Associated With Lower Trabecular BMD and Prevalent Vertebral Fracture in Older Adults

Ann V. Schwartz et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Article Geriatrics & Gerontology

Pathogenesis of Age-Related Bone Loss in Humans

Sundeep Khosla

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

Article Geriatrics & Gerontology

Age- and Menopause-Related Bone Loss Compromise Cortical and Trabecular Microstructure

Ego Seeman

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)

Article Endocrinology & Metabolism

Relationship between use of antidepressants and risk of fractures: a meta-analysis

V. Rabenda et al.

OSTEOPOROSIS INTERNATIONAL (2013)

Review Biochemistry & Molecular Biology

Ageing as a Risk Factor for Disease

Teresa Niccoli et al.

CURRENT BIOLOGY (2012)

Article Endocrinology & Metabolism

Relationship of age to bone microstructure independent of areal bone mineral density

Kristy M. Nicks et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2012)

Article Medicine, General & Internal

A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention

Heike A. Bischoff-Ferrari et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Article Medicine, General & Internal

Association of BMD and FRAX Score With Risk of Fracture in Older Adults With Type 2 Diabetes

Ann V. Schwartz et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Article Medicine, General & Internal

Gait Speed and Survival in Older Adults

Stephanie Studenski et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Editorial Material Endocrinology & Metabolism

The 2011 Report on Dietary Reference Intakes for Calcium and Vitamin D from the Institute of Medicine: What Clinicians Need to Know

A. Catharine Ross et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2011)

Article Geriatrics & Gerontology

Sarcopenia: European consensus on definition and diagnosis

Alfonso J. Cruz-Jentoft et al.

AGE AND AGEING (2010)

Article Rehabilitation

Effect of a 12-Week Yoga Intervention on Fear of Falling and Balance in Older Adults: A Pilot Study

Arlene A. Schmid et al.

ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION (2010)

Article Endocrinology & Metabolism

Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa

Kirsten Ecklund et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Endocrinology & Metabolism

Hip and calcaneal bone loss increase with advancing age: Longitudinal results from the study of osteoporotic fractures

Kristine E. Ensrud et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Endocrinology & Metabolism

Perspective how many women have osteoporosis?

L. Joseph Melton et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2010)

Article Endocrinology & Metabolism

Assessment of Individual Fracture Risk: FRAX and Beyond

Joop P. W. van den Bergh et al.

Current Osteoporosis Reports (2010)

Article Endocrinology & Metabolism

Increased Bone Marrow Fat in Anorexia Nervosa

Miriam A. Bredella et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2009)

Article Medicine, General & Internal

Serum 25-hydroxyvitamin D concentrations and risk for hip fractures

Jane A. Cauley et al.

ANNALS OF INTERNAL MEDICINE (2008)

Editorial Material Cell & Tissue Engineering

Mesenchymal stem cells: Revisiting history, concepts, and assays

Paolo Bianco et al.

CELL STEM CELL (2008)

Article Endocrinology & Metabolism

FRAX™ and the assessment of fracture probability in men and women from the UK

J. A. Kanis et al.

OSTEOPOROSIS INTERNATIONAL (2008)

Article Medicine, General & Internal

Zoledronic acid and clinical fractures and mortality after hip fracture

Kenneth W. Lyles et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Endocrinology & Metabolism

Quantifying osteoblast and osteocyte apoptosis: Challenges and rewards

Robert L. Jilka et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Cellular senescence in cancer and aging

Manuel Collado et al.

Article Endocrinology & Metabolism

Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss

JI Aguirre et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2006)

Article Medicine, General & Internal

Denosumab in postmenopausal women with low bone mineral density

MR McClung et al.

NEW ENGLAND JOURNAL OF MEDICINE (2006)

Review Medicine, General & Internal

Effect of vitamin D on falls - A meta-analysis

HA Bischoff-Ferrari et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

Article Medicine, General & Internal

Effects of estrogen plus progestin on risk of fracture and bone mineral density - The Women's Health Initiative randomized trial

JA Cauley et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Article Medicine, General & Internal

Association between falls in elderly women and chronic diseases and drug use: cross sectional study

DA Lawlor et al.

BRITISH MEDICAL JOURNAL (2003)

Article Cell Biology

Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone

BS Noble et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2003)

Article Endocrinology & Metabolism

The structural and hormonal basis of sex differences in peak appendicular bone strength in rats

BT Kim et al.

JOURNAL OF BONE AND MINERAL RESEARCH (2003)

Article Geriatrics & Gerontology

Central nervous system-active medications and risk for falls in older women

KE Ensrud et al.

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2002)

Article Medicine, General & Internal

Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis.

RM Neer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

Article Endocrinology & Metabolism

Long-term risk of osteoporotic fracture in Malmo

JA Kanis et al.

OSTEOPOROSIS INTERNATIONAL (2000)