期刊
MATERIALS LETTERS
卷 311, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.matlet.2021.131574
关键词
Biogenic silver nanoparticles; Self-assembled monolayers; Biofilm; Antimicrobial surface
Hospital-acquired infections (HAIs) are a serious medical threat affecting the efficacy of existing medical infrastructure, with antibiotics contributing to multi-drug resistant bacteria and biofilm formation. Silver nanoparticles (AgNPs) based antimicrobial surfaces show potential in preventing bacterial adhesion and biofilm formation, offering a promising solution to address the issue of HAIs.
Hospital-acquired infections (HAIs) are a serious medical threat nowadays, compromising the efficacy of the existing medical infrastructure. HAIs driven impact on the antibiotics usage resulted in further complications of (a) developing multi-drug resistant bacterial strain and (b) insignificant potential towards eradicating biofilm formation. To address this serious issue, we have developed silver nanoparticles (AgNPs) based antimicrobial surfaces using amine self-assembled monolayers. The biogenic spherical AgNPs (76 +/- 15 nm) were synthesized using a plant extract of Miscanthus khasiana (silver grass) as a reducing agent. The surface energy of AgNPs-amine surface was 38.2 mJ/m(2) and remained constant after the in-vitro stability test. The prepared surfaces hampered the bacterial adhesion and biofilm formation of Pseudomonas aeruginosa. A 67% reduction in the viability of the adhered bacteria was observed in the presence of the designed AgNPs-amine surface, confirming its antibiofilm potential.
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