期刊
CANCER CHEMOTHERAPY AND PHARMACOLOGY
卷 76, 期 6, 页码 1101-1112出版社
SPRINGER
DOI: 10.1007/s00280-015-2903-8
关键词
Taxanes; Epothilones; Vinca alkaloids; Estrogens; 2-Methoxyestradiol
资金
- Medical Research Council of South Africa
- Research Committee of the Faculty of Health Sciences of the University of Pretoria
- Cancer association of South Africa
- National Research Foundation
Cancer is a complex disease since it is adaptive in such a way that it can promote proliferation and invasion by means of an overactive cell cycle and in turn cellular division which is targeted by antimitotic drugs that are highly validated chemotherapy agents. However, antimitotic drug cytotoxicity to non-tumorigenic cells and multiple cancer resistance developed in response to drugs such as taxanes and vinca alkaloids are obstacles faced in both the clinical and basic research field to date. In this review, the classes of antimitotic compounds, their mechanisms of action and cancer cell resistance to chemotherapy and other limitations of current antimitotic compounds are highlighted, as well as the potential of novel 17-beta estradiol analogs as cancer treatment.
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