期刊
MARINE DRUGS
卷 20, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/md20040245
关键词
fucoxanthin; antioxidant; Parkinson's disease; ERK; JNK-c-Jun pathway
资金
- National Key R&D Program of China [2018YFD0901103, 2018YFD0900305]
- NSFC [31872540, 31772871]
- Major Scientific and Technological Project of Zhejiang Province [2021C02069-9]
- Zhejiang Province Nature Science Foundation of China [LQ20D060001, LY22C190002]
- Major Scientific and Technological Project of Ningbo [2021Z004, 2021Z104]
- Scientific and Technological Project of Ningbo [2021S063]
- Public-Benefit Foundation of Ningbo [202002N3171]
- China Agriculture Research System of MOF
- China Agriculture Research System of MARA
- K.C. Wong Magna Fund in Ningbo University
Fucoxanthin, extracted from seaweeds, has neuroprotective activity through its antioxidant properties. It can reduce cytotoxicity, inhibit cell apoptosis, and improve motor ability in Parkinson's disease patients with long-term l-DA administration.
As the most abundant marine carotenoid extracted from seaweeds, fucoxanthin is considered to have neuroprotective activity via its excellent antioxidant properties. Oxidative stress is regarded as an important starting factor for neuronal cell loss and necrosis, is one of the causes of Parkinson's disease (PD), and is considered to be the cause of adverse reactions caused by the current PD commonly used treatment drug levodopa (l-DA). Supplementation with antioxidants early in PD can effectively prevent neurodegeneration and inhibit apoptosis in dopaminergic neurons. At present, the effect of fucoxanthin in improving the adverse effects triggered by long-term l-DA administration in PD patients is unclear. In the present study, we found that fucoxanthin can reduce cytotoxicity and suppress the high concentration of l-DA (200 mu M)-mediated cell apoptosis in the 6-OHDA-induced PC12 cells through improving the reduction in mitochondrial membrane potential, suppressing ROS over-expression, and inhibiting active of ERK/JNK-c-Jun system and expression of caspase-3 protein. These results were demonstrated by PD mice with long-term administration of l-DA showing enhanced motor ability after intervention with fucoxanthin. Our data indicate that fucoxanthin may prove useful in the treatment of PD patients with long-term l-DA administration.
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