期刊
MARINE DRUGS
卷 20, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/md20060368
关键词
alkaloids; natural product; synthesis; biotechnological approaches; enzymatic reactions; chemoenzymatic strategies
资金
- Fundamental Research Funds for the Central Universities
- Sun Yat-sen University [22qntd2202]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011905]
This review discusses the research progress on marine-derived alkaloid synthesis via enzymatic reactions, as well as the advantages and disadvantages of their applications for industrial production and the green chemistry for marine natural product research.
Alkaloids are a large and structurally diverse group of marine-derived natural products. Most marine-derived alkaloids are biologically active and show promising applications in modern (agro)chemical, pharmaceutical, and fine chemical industries. Different approaches have been established to access these marine-derived alkaloids. Among these employed methods, biotechnological approaches, namely, (chemo)enzymatic synthesis, have significant potential for playing a central role in alkaloid production on an industrial scale. In this review, we discuss research progress on marine-derived alkaloid synthesis via enzymatic reactions and note the advantages and disadvantages of their applications for industrial production, as well as green chemistry for marine natural product research.
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