期刊
MAGNETIC RESONANCE IN MEDICINE
卷 88, 期 2, 页码 676-690出版社
WILEY
DOI: 10.1002/mrm.29233
关键词
CAPTURE; deep learning; free-breathing; P2P; PET; MRI; respiratory motion correction
资金
- Siemens Healthineers
The impact of PET respiratory motion correction (MoCo) was evaluated using MRI-assisted methods in both a phantom and patients with hepatic lesions. The results demonstrated that this approach improved quantitative and qualitative metrics of PET images, as well as lesion conspicuity.
Purpose We evaluated the impact of PET respiratory motion correction (MoCo) in a phantom and patients. Moreover, we proposed and examined a PET MoCo approach using motion vector fields (MVFs) from a deep-learning reconstructed short MRI scan. Methods The evaluation of PET MoCo was performed in a respiratory motion phantom study with varying lesion sizes and tumor to background ratios (TBRs) using a static scan as the ground truth. MRI-based MVFs were derived from either 2000 spokes (MoCo2000, 5-6 min acquisition time) using a Fourier transform reconstruction or 200 spokes (MoCoP2P200, 30-40 s acquisition time) using a deep-learning Phase2Phase (P2P) reconstruction and then incorporated into PET MoCo reconstruction. For six patients with hepatic lesions, the performance of PET MoCo was evaluated using quantitative metrics (SUVmax, SUVpeak, SUVmean, lesion volume) and a blinded radiological review on lesion conspicuity. Results MRI-assisted PET MoCo methods provided similar results to static scans across most lesions with varying TBRs in the phantom. Both MoCo2000 and MoCoP2P200 PET images had significantly higher SUVmax, SUVpeak, SUVmean and significantly lower lesion volume than non-motion-corrected (non-MoCo) PET images. There was no statistical difference between MoCo2000 and MoCoP2P200 PET images for SUVmax, SUVpeak, SUVmean or lesion volume. Both radiological reviewers found that MoCo2000 and MoCoP2P200 PET significantly improved lesion conspicuity. Conclusion An MRI-assisted PET MoCo method was evaluated using the ground truth in a phantom study. In patients with hepatic lesions, PET MoCo images improved quantitative and qualitative metrics based on only 30-40 s of MRI motion modeling data.
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