期刊
MACROMOLECULES
卷 -, 期 -, 页码 -出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.2c00561
关键词
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资金
- French Agence Nationale de la Recherche (ANR JCJC) [18-CE06-0002]
- iBiSA
- French Infrastructure for Integrated Structural Biology (FRISBI) [ANR-10-INSB-05-05]
The morphological evolution of graft copolymer-based nano-objects was monitored during their formulation in water by light scattering and electron microscopy. Unilamellar vesicles (ULVs) and large compound nano-objects (LCNs) were formed, and an unprecedented multicompartment vesicle (MCV) intermediate morphology was discovered, which was attributed to local phase separation between dextran and 2-hydroxypropyl methacrylate.
The morphological evolution of graft copolymer-based nano-objects was monitored by light scattering and electron microscopy during their formulation in water by polymerization induced self-assembly using a photo-mediated reversible addition-fragmentation chain transfer mechanism. The copolymer models used were composed of a dextran backbone bearing poly(2-hydroxypropyl methacrylate) grafts of two degrees of polymerization (X). At a full monomer conversion, unilamellar vesicles (ULVs) and large compound nano-objects (LCNs) were formed when targeting X = 100 and 500, respectively. For X = 100, some spherical, worm-like, then jellyfish-like structures were progressively observed before the ULVs formation. For X = SOO, electron cryotomography revealed an unprecedented intermediate morphology formed from the onset of self-assembly called a multicompartment vesicle (MCV) that fused to form LCN. The formation of MCV was attributed to a local phase separation between dextran and the residual 2-hydroxypropyl methacrylate inducing the appearance of multiple hydrophilic cores.
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