期刊
MACROMOLECULAR RAPID COMMUNICATIONS
卷 43, 期 10, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.202200089
关键词
click reaction; functionalization; melanin; surface coating; tyrosinase
资金
- National Research Foundation of Korea [2021R1C1C1005658]
- National Research Foundation of Korea [2021R1C1C1005658] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
A tyrosine-based azido derivative (TBAD) that can perform substrate-independent surface coating and clickable film functionalization is synthesized. The TBAD remains stable under alkaline and neutral conditions and is oxidized by tyrosinase to initiate melanin-like polymerization. The resulting poly(TBAD) film can be formed on various substrates and undergo click reaction with terminal alkyne moieties. This clickable coating technique could be significant for bioconjugation, soft lithography, and labeling techniques.
A tyrosine-based azido derivative (TBAD) that permits both substrate-independent surface coating and clickable film functionalization by mimicking natural melanogenesis is synthesized here. In contrast to catechol derivatives, which are generally susceptible to oxidation by air under ambient conditions, the monophenol-based TBAD remains stable under alkaline and neutral conditions and is activated to oxidized quinone in situ by tyrosinase to initiate melanin-like polymerization. The resulting poly(TBAD) film can be formed on various substrates including noble metals, metal oxides, and synthetic polymers, which can undergo click reaction with terminal alkyne moieties on the entire surface or a specific region through Cu(I)-catalyzed azide-alkyne cycloaddition. The enzyme-mediated coating can rapidly form thin films (approximate to 10 nm) and produce a uniform film morphology, which are important aspects in surface chemistry. This on-demand, clickable coating may become a significant tool for bioconjugation, soft lithography, and labeling techniques.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据