期刊
MACROMOLECULAR CHEMISTRY AND PHYSICS
卷 223, 期 11, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/macp.202200021
关键词
bioimaging; iridium and rhenium hybrid materials; photophysical properties; reversible addition-fragmentation chain transfer polymerization
资金
- Australian Research Council [FT190100017]
- Australian Government Research Training Program (RTP) scholarship
- Australian Research Council [FT190100017] Funding Source: Australian Research Council
Copolymers containing luminescent iridium and iridium/rhenium fragments were prepared through modification of a precursor polymer. These materials exhibit excellent luminescent properties and have potential applications in tissue imaging.
Well-defined copolymers containing luminescent iridium and hybrid iridium/rhenium fragments are prepared utilizing parent poly(n-butyl acrylamide-co-N-(1H-tetrazol-5-yl) acrylamide) as macromolecular chelating species. The parent (co)polymers are prepared via the modification of a precursor poly(pentafluorophenyl acrylate) (polyPFPA) homopolymer, prepared by reversible addition-fragmentation chain transfer polymerization, with n-butylamine and 5-aminotetrazole. Reaction of the parent copolymers with [Ir-2(ppy)(4)(mu-Cl-2)] (ppy = 2-phenylpyridine) yields modified copolymers containing the Ir(ppy)(2) fragment as a pendent group. Attachment of the Ir species is confirmed by a combination of photophysical studies, UV-Vis spectroscopy, and visually under irradiation with UV light. Importantly, it is demonstrated that the chelation of the Ir(ppy)(2) fragment to a polymeric scaffold does not impact the fundamental photophysical properties of the Ir species. Attachment of a second luminescent metal species, Re(CO)(3)(phen) (phen = 1,10-phenanthroline), gives hybrid materials containing Re(I) and Ir(III). The photophysical properties of these hybrid materials are consistent with the presence of both metal species and indicate the occurrence of energy transfer phenomena from the polymer-bound Ir to Re metal centers. Finally, it is demonstrated that the Ir modified polymers and the Ir/Re hybrid materials offer potential in tissue imaging applications with scope to tune both luminescent properties and biological specificity as evidenced from preliminary brain tissue staining experiments.
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