4.3 Article

Venetoclax in combination with hypomethylating agents or low dose cytarabine for relapsed and refractory acute myeloid leukemia

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

Clinical and molecular predictors of response and survival following venetoclax therapy in relapsed/refractory AML

Maximilian Stahl et al.

Summary: Combination therapy of venetoclax is effective in many patients with relapsed or refractory AML, with azacitidine+venetoclax showing higher response rates compared to low-dose cytarabine+venetoclax. Clinical and molecular characteristics of patients may predict treatment outcomes in this population.

BLOOD ADVANCES (2021)

Article Hematology

Single-center experience with venetoclax combinations in patients with newly diagnosed and relapsed AML evolving from MPNs

Lucia Masarova et al.

Summary: In patients with acute myeloid leukemia evolving from myeloproliferative neoplasms, the clinical activity of the B-cell lymphoma 2 inhibitor venetoclax remains to be determined. Venetoclax-based regimens showed modest short-lived responses in newly diagnosed patients, while no formal responses were seen in relapsed/refractory patients. However, significant treatment-associated hematologic toxicity and mortality were observed, highlighting the urgent need for additional treatment options for these patients.

BLOOD ADVANCES (2021)

Article Oncology

Venetoclax is safe and efficacious in relapsed/refractory AML

Chezi Ganzel et al.

LEUKEMIA & LYMPHOMA (2020)

Article Medicine, General & Internal

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia

C. D. DiNardo et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)