期刊
LETTERS IN ORGANIC CHEMISTRY
卷 19, 期 12, 页码 1128-1131出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570178619666220527161914
关键词
Triterpenes; immune suppression; Kadsura coccinea; secolanostane; rheumatoid arthritis; TCMs
This study conducted phytochemical research on the root of Kadsura coccinea and isolated a previously undescribed compound. The compound exhibited moderate immune-suppressive activity, suggesting its potential use in the treatment of rheumatic diseases.
Kadsura coccinea is a folk medicine from the family Schisandraceae. Clinically, it has been used to treat many diseases like chronic gastritis and rheumatoid arthritis (RA). Lignans and triterpenes are the main constituents of it. In this paper, phytochemical research on the root of K. coccinea was carried out, leading to the isolation of a previously undescribed 3,4-secolanostane (1). Its structure was established by means of comprehensive spectral analysis, including ECD calculation. Furthermore, bioactivity assay revealed that 1 could elicit a moderate immune-suppressive activity, showing an IC50 value of 8.32 +/- 0.13 mu M against ConA-induced T-cell proliferation and with IC50 value of 15.58 +/- 0.25 mu M against LPS-induced B-cell proliferation. The results indicate that 1 might be used in the treatment of rheumatic diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据