4.2 Article

An Immune-Suppressive Triterpenoid from the Roots of Kadsura coccinea

期刊

LETTERS IN ORGANIC CHEMISTRY
卷 19, 期 12, 页码 1128-1131

出版社

BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1570178619666220527161914

关键词

Triterpenes; immune suppression; Kadsura coccinea; secolanostane; rheumatoid arthritis; TCMs

向作者/读者索取更多资源

This study conducted phytochemical research on the root of Kadsura coccinea and isolated a previously undescribed compound. The compound exhibited moderate immune-suppressive activity, suggesting its potential use in the treatment of rheumatic diseases.
Kadsura coccinea is a folk medicine from the family Schisandraceae. Clinically, it has been used to treat many diseases like chronic gastritis and rheumatoid arthritis (RA). Lignans and triterpenes are the main constituents of it. In this paper, phytochemical research on the root of K. coccinea was carried out, leading to the isolation of a previously undescribed 3,4-secolanostane (1). Its structure was established by means of comprehensive spectral analysis, including ECD calculation. Furthermore, bioactivity assay revealed that 1 could elicit a moderate immune-suppressive activity, showing an IC50 value of 8.32 +/- 0.13 mu M against ConA-induced T-cell proliferation and with IC50 value of 15.58 +/- 0.25 mu M against LPS-induced B-cell proliferation. The results indicate that 1 might be used in the treatment of rheumatic diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据