期刊
LETTERS IN APPLIED MICROBIOLOGY
卷 75, 期 1, 页码 24-28出版社
OXFORD UNIV PRESS
DOI: 10.1111/lam.13696
关键词
algae; algicidal effect; mastitis; Prototheca bovis; protothecosis
资金
- Brazilian funding agency Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Brazilian funding agency Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Brazilian funding agency Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
This study evaluated the therapeutic potential of biogenic silver nanoparticles (Bio-AgNP) against Prototheca spp. The results showed that Bio-AgNP exhibited algaecide activity against Prototheca spp., indicating its potential as a novel therapeutic approach.
Prototheca spp. cause numerous infections in a wide variety of species, including treatment-unresponsive mastitis. Thus, the search for an effective therapy is essential. Silver nanoparticles are compounds with high therapeutic potential. This study aimed to evaluate the susceptibility profile and morphological changes in Prototheca spp. treated with biogenic silver nanoparticles (Bio-AgNP). The algaecide activity was evaluated in microplates by microdilution method, resulting in a MIC50 of 30 mu g ml(-1) and a MIC90 of 60 mu g ml(-1). Scanning electron microscopy demonstrated changes in the surface of Prototheca bovis cells following treatment. The algaecide activity of Bio-AgNP suggests a therapeutic potential as a novel approach for the control of Prototheca spp. in bovine mastitis.
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