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Aquaporin-1 variants: a step further towards precise prescription in peritoneal dialysis?

KIDNEY INTERNATIONAL (2022)

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis

Johann Morelle et al.

Summary: A common variant in AQP1 is associated with decreased ultrafiltration and an increased risk of death or technique failure among patients treated with peritoneal dialysis.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Genetics & Heredity

Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

Abul Kalam Azad et al.

Summary: AQPs are integral membrane proteins involved in transmembrane diffusion of water and small solutes bidirectionally. They are functionally diverse and associated with a wide range of non-infectious diseases, while their role in infectious diseases remains to be fully evaluated. Studies suggest that AQPs can be regulated by microbial and parasitic infections, indicating their involvement in microbial pathogenesis, inflammation-related responses, and cell water homeostasis.

FRONTIERS IN GENETICS (2021)

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Article Urology & Nephrology

A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis

Rajnish Mehrotra et al.

Summary: Genetic variants are associated with variability in peritoneal solute transfer rate among patients receiving peritoneal dialysis. There is evidence of a genetic contribution to inter-individual variability in PSTR, as revealed through a genome-wide association study. The estimated heritability of PSTR is 19%, indicating a substantial genetic component influencing solute transfer rate in peritoneal dialysis patients.

KIDNEY INTERNATIONAL (2021)

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Article Urology & Nephrology

Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis

J Ni et al.

KIDNEY INTERNATIONAL (2006)

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Article Urology & Nephrology

Functional and molecular characterization of a peritoneal dialysis model in the C57BL/6J mouse

J Ni et al.

KIDNEY INTERNATIONAL (2005)

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Article Medicine, General & Internal

Brief report: Defective urinary concentrating ability due to a complete deficiency of aquaporin-1

LS King et al.

NEW ENGLAND JOURNAL OF MEDICINE (2001)

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Aquaporin-1 variants: a step further towards precise prescription in peritoneal dialysis?

相关参考文献

AQP1 Promoter Variant, Water Transport, and Outcomes in Peritoneal Dialysis

Human Aquaporins: Functional Diversity and Potential Roles in Infectious and Non-infectious Diseases

A genome-wide association study suggests correlations of common genetic variants with peritoneal solute transfer rates in patients with kidney failure receiving peritoneal dialysis

Aquaporin-1 plays an essential role in water permeability and ultrafiltration during peritoneal dialysis

Functional and molecular characterization of a peritoneal dialysis model in the C57BL/6J mouse

Brief report: Defective urinary concentrating ability due to a complete deficiency of aquaporin-1

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