Should we consider calcimimetics as a therapeutic option for nephrotic syndrome?

Calcimimetics allosterically increase the calcium ion sensitivity of the calcium-sensing receptor (CaSR). Using a CaSR knockdown in podocytes and a podocyte-specific CaSR knockout in mice, Muhlig et al. uncovered a stabilizing role for actin cytoskeleton and cell adhesion. Short-term alleviation of albuminuria and proteinuria was observed in 4 children treated with cinacalcet. Here we discuss the potential mechanisms whereby CaSR displays a favorable effect in podocytes and the context in which calcimimetics may alleviate nephrotic syndrome. Copyright (C) 2022, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Automated summary

This study reveals the important role of actin cytoskeleton and cell adhesion in maintaining the stability of CaSR in podocytes, and suggests the potential benefits of calcimimetics in improving podocyte function.