期刊
JOURNAL OF VIROLOGY
卷 96, 期 9, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/jvi.00051-22
关键词
hepatitis B virus; HBV; spacer; evolution; diversity; polymorphism; polymerase; genotype; phylogeny
类别
资金
- Wellcome intermediate fellowship [110110/Z/15/Z]
- University of Oxford
- Wellcome Trust
- GSK
This study explores the role of the spacer sequence in HBV evolution and lineage, its associations with drug and immune evasion, and potential impacts on disease outcomes.
Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes. Hepatitis B virus (HBV) polymerase is divided into terminal protein, spacer, reverse transcriptase, and RNase domains. Spacer has previously been considered dispensable, merely acting as a tether between other domains or providing plasticity to accommodate deletions and mutations. We explore evidence for the role of spacer sequence, structure, and function in HBV evolution and lineage, consider its associations with escape from drugs, vaccines, and immune responses, and review its potential impacts on disease outcomes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据