☆ 4.6 Article

Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

JOURNAL OF VIROLOGY (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemistry & Molecular Biology

Scanning the RBD-ACE2 molecular interactions in Omicron variant

Soumya Lipsa Rath et al.

Summary: The emergence of new SARS-CoV-2 variants poses a threat to the human population, and assessing their severity is challenging. This study compares the interaction of the wild-type and the latest Omicron variant using molecular dynamics simulations, revealing diverse changes in the properties of the mutated protein complex. These findings enhance our understanding of the binding mechanism between the Omicron variant and the wild-type SARS-CoV-2.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic

Markus Hoffmann et al.

Summary: The Omicron variant of SARS-CoV-2 is spreading rapidly and shows resistance to most therapeutic antibodies. It also evades neutralization by antibodies induced by infection or vaccination more efficiently than the Delta variant. This suggests that therapeutic antibodies may not be effective against the Omicron variant, and double vaccination with BNT162b2 may not provide adequate protection against severe disease caused by this variant.

CELL (2022)

添加到收藏夹

Article Immunology

Neutralization of Severe Acute Respiratory Syndrome Coronavirus 2 Omicron Variant by Sera From BNT162b2 or CoronaVac Vaccine Recipients

Lu Lu et al.

Summary: Immune sera from BNT162b2 and Coronavac recipients showed reduced neutralizing antibody titers against the omicron variant. The presence of the spike R346K mutation did not affect the neutralization susceptibility.

CLINICAL INFECTIOUS DISEASES (2022)

添加到收藏夹

Article Multidisciplinary Sciences

Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization

Sandile Cele et al.

Summary: The study found that the Omicron variant has reduced neutralizing effectiveness in individuals vaccinated with Pfizer BNT162b2, but those who had previously been infected with SARS-CoV-2 showed better neutralization against Omicron.

NATURE (2022)

添加到收藏夹

Article Biochemistry & Molecular Biology

Ancestral SARS-CoV-2-specific T cells cross-recognize the Omicron variant

Yu Gao et al.

Summary: This study found that SARS-CoV-2 spike-specific CD4(+) and CD8(+) T cells induced by prior infection or BNT162b2 vaccination provide extensive immune coverage against the Omicron variant. Additionally, T cells induced by BNT162b2 vaccination exhibit higher cross-reactivity to the Omicron variant compared to T cells induced by prior SARS-CoV-2 infection.

NATURE MEDICINE (2022)

添加到收藏夹

Article Immunology

SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells

Hanjun Zhao et al.

Summary: The Omicron variant of SARS-CoV-2 has distinct virological characteristics compared to the Delta variant. It replicates more slowly and its entry pathway is mediated primarily through the endocytic pathway instead of TMPRSS2 pathway. This difference in entry pathway may have implications for the clinical manifestations or severity of the disease.

EMERGING MICROBES & INFECTIONS (2022)

添加到收藏夹

Article Immunology

The significant immune escape of pseudotyped SARS-CoV-2 variant Omicron

Youchun Wang et al.

Summary: The Omicron variant shows greater potential for immune escape compared to other variants, suggesting a significant impact on immunity from previous infections and vaccines.

EMERGING MICROBES & INFECTIONS (2022)

添加到收藏夹

Letter Biochemistry & Molecular Biology

SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2

Leyun Wu et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

添加到收藏夹

Article Infectious Diseases

Outbreak caused by the SARS-CoV-2 Omicron variant in Norway, November to December 2021

Lin T. Brandal et al.

Summary: In the Omicron SARS-CoV-2 outbreak in Oslo, Norway, most infected individuals were aged 30-50, 96% were vaccinated, with an attack rate of 74%, but none required hospitalization.

EUROSURVEILLANCE (2021)

添加到收藏夹

Article Infectious Diseases

Epidemiological characterisation of the first 785 SARS-CoV-2 Omicron variant cases in Denmark, December 2021

Laura Espenhain et al.

Eurosurveillance (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape

Zhiqiang Ku et al.

Summary: Antibody cocktails are a promising approach to prevent SARS-CoV-2 escape, with a combination of antibodies CoV2-06 and CoV2-14 identified as effective in preventing viral escape and providing protection in mice, offering new insights for treating COVID-19.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

New targets for drug design: importance of nsp14/nsp10 complex formation for the 3'-5' exoribonucleolytic activity on SARS-CoV-2

Margarida Saramago et al.

Summary: The SARS-CoV-2 virus nucleocapsid nsp14 is a multifunctional protein critical for the virus lifecycle. Research has uncovered how nsp14 activity is regulated by the nsp10 protein, laying the groundwork for developing inhibitors targeting specific amino acids to disrupt coronavirus replication.

FEBS JOURNAL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift

Elisabetta Cameroni et al.

NATURE (2021)

添加到收藏夹

News Item Multidisciplinary Sciences

HEAVILY MUTATED OMICRON VARIANT PUTS SCIENTISTS ON ALERT

Ewen Callaway

NATURE (2021)

添加到收藏夹

Article Virology

The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral Defense

Cem Azgari et al.

Summary: Understanding the evolution of SARS-CoV-2 is crucial in managing the COVID-19 pandemic, with mutagenesis and selection being key mechanisms. This study used a phylogenetic approach to reveal the contribution of mutagenesis and selection to the genetic diversity of SARS-CoV-2 genomes, showing that mutation patterns are influenced by host antiviral mechanisms and potential adaptive responses.

VIRUSES-BASEL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Spike residue 403 affects binding of coronavirus spikes to human ACE2

Fabian Zech et al.

Summary: By exchanging residue 403 between RaTG13 and SARS-CoV-2 spike proteins, researchers demonstrated the impact on binding to human ACE2 and entry of pseudotyped viruses. This finding suggests the potential of vaccination to protect against future zoonotic diseases.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Medicine, General & Internal

Emerging SARS-CoV-2 variants expand species tropism to murines

Huiping Shuai et al.

Summary: The study found that the SARS-CoV-2 variant B.1.1.7 and other N501Y-carrying variants can infect wildtype mice and rats, producing high viral loads and infectious virus particles in their respiratory tract. This suggests that these variants may have evolved to expand species tropism to murines.

EBIOMEDICINE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Thushan de Silva et al.

Summary: Variants within dominant SARS-CoV-2 T cell epitopes have been identified through global sequence data analysis. These variants, independently arising in multiple lineages, result in loss of T cell recognition of specific epitopes. The findings demonstrate the potential for T cell evasion and emphasize the importance of ongoing surveillance for variants capable of escaping immune responses.

ISCIENCE (2021)

添加到收藏夹

Article Cell Biology

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

Manuel Hayn et al.

Summary: SARS-CoV-2 proteins synergize to counteract innate immune responses, but they are vulnerable to type II and III interferons. Experimental results show potent inhibition of SARS-CoV-2 infection by interferon-gamma and lambda 1, highlighting potential for effective antiviral approaches.

CELL REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization

Delphine Planas et al.

Summary: The SARS-CoV-2 B.1.617 Delta variant, first identified in India in 2020, has become dominant in some regions and is spreading to many countries. This variant shows resistance to certain monoclonal antibodies and antibodies in convalescent sera, as well as reduced neutralization by some COVID-19 vaccines. Administration of two doses of the vaccine is needed for a neutralizing response against the Delta variant.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies

Florian A. Lempp et al.

Summary: The study reveals that C-type lectin receptors and other factors can serve as attachment receptors for SARS-CoV-2 infection, enhancing ACE2-mediated infection and modulating the neutralizing activity of antibodies.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape

Fabian Schmidt et al.

Summary: The number and variability of neutralizing epitopes targeted by polyclonal antibodies in individuals who have recovered from SARS-CoV-2 or been vaccinated play a crucial role in determining the breadth of neutralization and the genetic barrier to viral escape. Studying HIV-1 pseudotypes and plasma selection experiments, it was found that human polyclonal antibodies target multiple neutralizing epitopes within and outside the receptor-binding domain, and antibody targets coincide with spike sequences enriched for diversity in natural SARS-CoV-2 populations. Combining plasma-selected spike substitutions led to the generation of 'polymutant' spike protein pseudotypes that resist neutralization by polyclonal antibodies to a similar extent as circulating variants of concern. Plasma from individuals who had been infected with SARS-CoV-2 and subsequently received mRNA vaccination was able to neutralize highly resistant SARS-CoV-2 variants, suggesting that optimally elicited polyclonal antibodies can provide protection against future SARS-CoV-2 variations and potential sarbecovirus pandemics.

NATURE (2021)

添加到收藏夹

Article Microbiology

SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

Yongzhen Liu et al.

Summary: The study reveals the innate immune evasion strategy of SARS-CoV-2 mediated by the Nsp5 main protease and the development of a small-molecule inhibitor, which restores the innate immune response and inhibits viral replication. These findings provide potential antiviral agents for treating COVID-19 patients.

MBIO (2021)

添加到收藏夹

Article Multidisciplinary Sciences

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

Caterina Prelli Bozzo et al.

Summary: IFITM proteins can restrict viral pathogens, but they also support efficient infection of SARS-CoV-2 in human lung cells. The spike protein of SARS-CoV-2 interacts with IFITMs and hijacks them for viral infection, making IFITM proteins potential therapeutic targets for inhibiting virus entry and replication.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Article Cell Biology

Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Bo Meng et al.

Summary: The Delta H69N70 mutation in SARS-CoV-2 spike protein increases infectivity and partially rescues immune escape mutations that impair infectivity. Continued surveillance and research on deletions with functional effects are necessary.

CELL REPORTS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development

Miao-Miao Zhao et al.

Summary: CTSL plays a crucial role in COVID-19 patients, with its levels positively correlated with disease severity. Research showed that CTSL promotes SARS-CoV-2 virus entry into cells, and the CTSL inhibitor amantadine can inhibit this process, providing a direction for the development of new anti-COVID-19 drugs.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Host-directed editing of the SARS-CoV-2 genome

Tobias Mourier et al.

Summary: The extensive sequence data from SARS-CoV-2 in 2020 pandemic has facilitated the study of viral genome evolution, revealing instances of directional mutation pressures exerted on the genome by host antiviral defense systems. It discusses three human defense mechanisms – APOBEC, ADAR, and ROS – and their potential implications on SARS-CoV-2 evolution.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)

添加到收藏夹

Review Immunology

Viral targets for vaccines against COVID-19

Lianpan Dai et al.

Summary: The urgent need for vaccines to control the COVID-19 pandemic has led to the rapid development of multiple vaccine candidates, with some showing positive results in late-stage clinical trials. This article discusses the viral elements used in these candidates, the reasons why they are good targets for the immune system, and their implications for protective immunity. Dai and Gao highlight the importance of selecting the right viral targets in vaccine development to ensure an effective immune response and the overall safety and efficacy of the vaccine.

NATURE REVIEWS IMMUNOLOGY (2021)

添加到收藏夹

Article Microbiology

Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses

Michael Letko et al.

NATURE MICROBIOLOGY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

添加到收藏夹

Article Infectious Diseases

Evolutionary analysis of SARS-CoV-2: how mutation of Non-Structural Protein 6 (NSP6) could affect viral autophagy

Domenico Benvenuto et al.

JOURNAL OF INFECTION (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Structure of replicating SARS-CoV-2 polymerase

Hauke S. Hillen et al.

NATURE (2020)

添加到收藏夹

Article Microbiology

A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition

M. Eugenia Dieterle et al.

CELL HOST & MICROBE (2020)

添加到收藏夹

Article Microbiology

Rampant C -> U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

P. Simmonds

MSPHERE (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting

Fran Robson et al.

MOLECULAR CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

Donald J. Benton et al.

NATURE (2020)

添加到收藏夹

Article Virology

Coronavirus Antiviral Research Database (CoV-RDB): An Online Database Designed to Facilitate Comparisons between Candidate Anti-Coronavirus Compounds

Philip L. Tzou et al.

VIRUSES-BASEL (2020)

添加到收藏夹

Article Microbiology

SARS-CoV-2 Is Restricted by Zinc Finger Antiviral Protein despite Preadaptation to the Low-CpG Environment in Humans

Rayhane Nchioua et al.

MBIO (2020)

添加到收藏夹

Article Cell Biology

Evasion of Type I Interferon by SARS-CoV-2

Hongjie Xia et al.

CELL REPORTS (2020)

添加到收藏夹

Article Multidisciplinary Sciences

APOBEC3-mediated restriction of RNA virus replication

Aleksandra Milewska et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Biochemistry & Molecular Biology

Virus Variation Resource - improved response to emergent viral outbreaks

Eneida L. Hatcher et al.

NUCLEIC ACIDS RESEARCH (2017)

添加到收藏夹

Article Multidisciplinary Sciences

CG dinucleotide suppression enables antiviral defence targeting non-self RNA

Matthew A. Takata et al.

NATURE (2017)

添加到收藏夹

Article Multidisciplinary Sciences

Data, disease and diplomacy: GISAID's innovative contribution to global health

Stefan Elbe et al.

GLOBAL CHALLENGES (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

The APOBEC Protein Family: United by Structure, Divergent in Function

Jason D. Salter et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

添加到收藏夹

Article Virology

An integrated map of HIV genome-wide variation from a population perspective

Guangdi Li et al.

RETROVIROLOGY (2015)

添加到收藏夹

Article Biochemistry & Molecular Biology

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

Fabian Sievers et al.

MOLECULAR SYSTEMS BIOLOGY (2011)

添加到收藏夹

Article Microbiology

Infidelity of SARS-CoV Nsp14-Exonuclease Mutant Virus Replication Is Revealed by Complete Genome Sequencing

Lance D. Eckerle et al.

PLOS PATHOGENS (2010)

添加到收藏夹

Review Virology

Nidovirales:: Evolving the largest RNA virus genome

AE Gorbalenya et al.

VIRUS RESEARCH (2006)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.