期刊
JOURNAL OF THORACIC ONCOLOGY
卷 17, 期 3, 页码 461-466出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jtho.2021.08.765
关键词
Meningioma; BAP1; Mesothelioma; Germline
This study reports the co-occurrence of pleural mesotheliomas and meningiomas in patients with germline BAP1 mutations. The authors describe the cancer history, family pedigrees, clinical management, and outcomes of four BAP1 germline mutation carrier families with a history of malignant mesothelioma and meningioma.
BAP1 is a tumor suppressor gene implicated in DNA repair and cell growth. Individuals with germline BAP1 mutations are at a significantly increased risk for developing many different cancers including malignant mesothelioma, uveal melanomas, cutaneous melanomas and renal clear cell carcinomas. Meningiomas with absent BAP1 expression have been reported to be more aggressive and present often with rhabdoid features. Here, we report the co-occurrence of pleural mesotheliomas and meningiomas in patients with germline BAP1 mutations. We describe the cancer history, family pedigrees, clinical management, and outcomes of four BAP1 germline mutation carrier families with a history of malignant mesothelioma and meningioma. (c) 2021 Published by Elsevier Inc. on behalf of International Association for the Study of Lung Cancer.
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