4.7 Article

One-pot green reduction and surface decoration of graphene oxide nanosheets with PEGylated chitosan for application in cancer photothermal therapy

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ELSEVIER
DOI: 10.1016/j.jtice.2022.104359

关键词

One-pot green reduction and PEGylation; Reduced graphene oxide nanosheets; PEGylated chitosan; NIR-triggered hyperthermia; Cancer photothermal therapy

资金

  1. Ministry of Science and Technology [MOST 108-2221-E-005-024-MY2, MOST 108-2731-M-005-001, MOST 110-2628-E-005-001]

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This study successfully developed PCS20k-decorated rGO nanosheets, which exhibited excellent dispersion in high salt and serum-containing environment. These nanosheets had higher photothermal conversion efficiency under near-infrared irradiation and effectively suppressed the growth of cancer cells.
Background: The practical applications of reduced graphene oxide (rGO) nanosheets in cancer photothermal therapy (PTT) are still largely limited by their poor dispersion in serum-containing environment, irreversible aggregation and potential cytotoxicity.Methods: To conquer the above challenges, in this work, the PEGylated chitosan20k (PCS20k)-decorated rGO (PCS-rGO) nanosheets were developed by one-pot green reduction and PEGylation of GO nanosheets using PCS as a novel reducing and stabilizing agent.Significant findings: In addition to the decreased particle size, the reduction degree of GO nanosheets was significantly increased by raising the mass ratio of PCS20k and GO from 4/1 to 16/1. Notably, in the high salt and serum-containing milieu, distinct from GO nanosheets with massive aggregation, the PCS20k-rGO nano sheets exhibited virtually unchanged particle size (ca. 170 >> 200 nm), indicating their prominent dispersion due to the nearly neutral and PEG-rich surfaces. Importantly, under 808 nm near-infrared (NIR) irradiation, the PCS20k-rGO nanosheets exhibited photothermal conversion efficiency (77 = 67.7%) superior to GO nano sheets (77 = 55.0%). The in vitro cellular uptake and cytotoxicity studies revealed that the internalized PCS20k-rGO nanosheets effectively ablated cancer cells upon NIR-elicited hyperthermia (over 49 degrees C), suggesting their great potential in applications of cancer PTT.(c) 2022 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

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