期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 130, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jmbbm.2022.105205
关键词
Human aorta; Mock circulatory loop; Hysteresis loop; Viscoelasticity; Mass density
资金
- NSERC Discovery Grant
- NSERC RTI grant
In this study, healthy human descending thoracic aortas were tested in a mock circulatory loop to measure their mechanical response to physiological pulsatile pressure and flow. The viscoelastic properties and dynamic stiffness ratio of the aortic segments were investigated, while the shape of the deformed aorta under static and dynamic pressure was measured by image processing. Layer-specific experiments were also conducted to identify the mass density of the aortic tissue.
Healthy human descending thoracic aortas, obtained during organ donation for transplant and research, were tested in a mock circulatory loop to measure the mechanical response to physiological pulsatile pressure and flow. The viscoelastic properties of the aortic segments were investigated at three different pulse rates. The same aortic segments were also subjected to quasi-static pressure tests in order to identify the aortic dynamic stiffness ratio, which is defined as the ratio between the stiffness in case of pulsatile pressure and the stiffness measured for static pressurization, both at the same value of pressure. The loss factor was also identified. The shape of the deformed aorta under static and dynamic pressure was measured by image processing to verify the compatibility of the end supports with the natural deformation of the aorta in the human body. In addition, layer-specific experiments on 10 human descending thoracic aortas allowed to precisely identify the mass density of the aortic tissue, which is an important parameter in cardiovascular dynamic models.
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