期刊
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
卷 31, 期 1, 页码 197-202出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ja00293a
关键词
-
资金
- Australian Research Council [LP100200079, LP120200081]
- Movember Foundation
- Prostate Cancer Foundation of Australia
- Australian Government Department of Health
- Australian Research Council [LP100200079, LP120200081] Funding Source: Australian Research Council
Elemental bio-imaging (EBI) of trace metal distributions in tissue sections is typically performed by laser ablation-single quadrupole-inductively coupled plasma-mass spectrometry (LA-ICP-SQ-MS) in which the sensitivity of biologically relevant elements such as Fe may be inhibited by polyatomic interferences. The triple quadrupole ICP-MS (ICP-QQQ-MS) is designed to reduce interferences and was examined for its potential application to EBI. Three tune modes; a no-gas, an H-2, and an O-2/H-2 tune were developed and investigated for their suitability. All three performed well with high signal to noise ratios and low limits of detection. The O-2/H-2 tune was applied to a prostate cancer biopsy sample, with high levels of Zn found in the area correlating with the cancer. The oxygen mass shift was applied to image P and Se in a mouse brain. The unique focussing properties of the ICP-QQQ-MS and the ability to use mixed cell gases provided sensitive analyses of all measured isotopes with the O-2/H-2 tune, including those unaffected by mass shift reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据