Patch testing with glucosides: The North American Contact Dermatitis Group experience, 2009-2018

Background: Alkyl glucosides are nonionic surfactants that are increasingly used in personal care products. Objective: To characterize positive patch test reactions to decyl glucoside (5% petrolatum, tested 2009-2018) and lauryl glucoside (3% petrolatum, tested 2017-2018). Methods: Retrospective analysis of patients tested by the North American Contact Dermatitis Group. Results: Of 24,097 patients patch tested to decyl and/or lauryl glucoside, 470 (2.0%) had positive reactions. Compared with glucoside-negative patients, glucoside-positive patients had higher odds of occupational skin disease (13.4% vs 10.1%; P = .0207), history of hay fever (38.5% vs 31.6%; P = .0014), atopic dermatitis (39.0% vs 28.6%; P \.0001), and/or asthma (21.8% vs 16.5%; P = .0023). Most glucoside reactions (83.9%) were currently relevant. The most common source was personal care products (63.0%), especially hair products (16.5%) and skin cleansers (15.2%). Of 4933 patients tested to decyl and lauryl glucoside, 134 (2.7%) were positive to 1 or both; 43.4% (43 of 99) of decyl-positive patients were also positive to lauryl glucoside and 55.1% (43/78) of lauryl glucoside patients were also positive to decyl glucoside. Limitations: The cohort predominantly reflects a referral population, and follow-up after testing was not captured. Conclusion: Glucoside positivity occurred in 2.0% of the tested patients. Reactions were often clinically relevant and linked to personal care products. Cross-reactivity was >40%.

Automated summary

This study retrospectively analyzed patients who underwent patch testing for two types of glucosides, and found that 2.0% of patients had positive reactions. These reactions were often linked to personal care products and cross-reactivity may be present.