期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 55, 期 2, 页码 465-471出版社
IOS PRESS
DOI: 10.3233/JAD-160316
关键词
Alzheimer's disease; amyloid; F-18-AV-1451; F-18-FDG; molecular imaging; multimodal imaging; Pittsburgh compound B; positron-emission tomography; T-807; tau protein
The clinical heterogeneity of Alzheimer's disease is not reflected in the rather diffuse cortical deposition of amyloid-beta. We assessed the relationship between clinical symptoms, in vivo tau pathology, amyloid distribution, and hypometabolism in variants of Alzheimer's disease using novel multimodal PET imaging techniques. Tau pathology was primarily observed in brain regions related to clinical symptoms and overlapped with areas of hypometabolism. In contrast, amyloid-beta deposition was diffusely distributed over the entire cortex. Tau PET imaging may thus serve as a valuable biomarker for the localization of neuronal injury in vivo and may help to validate atypical subtypes of Alzheimer's disease.
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