期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 54, 期 4, 页码 1349-1357出版社
IOS PRESS
DOI: 10.3233/JAD-160430
关键词
Alpha-synuclein; Alzheimer's disease; Lewy bodies; methylation; SNCA
资金
- Health and Labor Science Research Grant from Japanese Ministry of Health, Labour and Welfare
- Japanese Ministry of Education, Culture, Sports, Science and Technology, JSPS KAKENHI [15K09808]
Despite the continuing debate about the amyloid hypothesis in Alzheimer's disease (AD), the precise pathogenesis is still unclear. Mixed pathology is common and multiple different protein aggregates are seen in human postmortem brains. Aggregates consisting of the alpha-synuclein protein encoded by the Synuclein Alpha gene (SCNA) are common in both dementia with Lewy bodies and AD. We examined SNCA mRNA expression and methylation rates of the CpG island at intron 1 of SNCA in peripheral leukocytes in 50 AD and age- and sex-matched control subjects to verify whether alpha-synuclein pathology affects the AD pathogenesis. SNCA mRNA expression in AD subjects was significantly higher than that in control subjects (1.62 +/- 0.73 versus 0.98 +/- 0.50, p< 0.001). We found significant differences between AD and control subjects at seven CpG sites (average rate; 8.8 +/- 2.7 versus 9.5 +/- 2.5, respectively: p = 0.027). The methylation rates tended to be lower in AD subjects at all CpG sites. We conclude that mRNA expression and methylation of SNCA intron 1 are altered in AD, which may be caused by Lewy body pathology in AD.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据