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Insomnia disorder: State of the science and challenges for the future

JOURNAL OF SLEEP RESEARCH (2022)

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Article Psychiatry

Treating Insomnia with High Risk of Depression Using Therapist-Guided Digital Cognitive, Behavioral, and Circadian Rhythm Support Interventions to Prevent Worsening of Depressive Symptoms: A Randomized Controlled Trial

Jeanne Leerssen et al.

Summary: The study shows that therapist-guided cognitive behavioral therapy for insomnia (CBT-I) and circadian rhythm support (CRS) are effective in preventing the worsening of depressive symptoms in high-risk individuals with insomnia, with the combination of CBT-I+CRS being the most effective. Treatment adherence was higher with therapist-guided interventions compared to previous automated interventions.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2022)

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Review Clinical Neurology

Cognitive behavioral therapy for insomnia in patients with mental disorders and comorbid insomnia: A systematic review and meta-analysis

Elisabeth Hertenstein et al.

Summary: This meta-analysis aimed to evaluate the effectiveness of cognitive behavioral therapy for insomnia (CBT-I) in patients with mental disorders and comorbid insomnia. The results showed that CBT-I had significant and lasting effects on insomnia severity and mental health in patients with depression, PTSD, and alcohol dependency.

SLEEP MEDICINE REVIEWS (2022)

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Review Clinical Neurology

Comparative efficacy of digital cognitive behavioral therapy for insomnia: A systematic review and network meta-analysis

Faizul Hasan et al.

Summary: A network meta-analysis of digital cognitive behavioral therapy for insomnia in adults found that web-based CBTi combined with a therapist significantly improves sleep duration, sleep onset latency, wake after sleep onset, and sleep efficiency compared to usual care. The analysis suggests that this treatment is most likely to be ranked the highest among all treatments, indicating that it is the optimal intervention for improving sleep outcomes.

SLEEP MEDICINE REVIEWS (2022)

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Article Psychiatry

Prevention of Incident and Recurrent Major Depression in Older Adults With Insomnia A Randomized Clinical Trial

Michael R. Irwin et al.

Summary: The study found that cognitive behavioral therapy for insomnia (CBT-I) has an overall benefit in preventing incident and recurrent major depression in older adults with insomnia disorder.

JAMA PSYCHIATRY (2022)

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Article Clinical Neurology

Large-scale implementation of insomnia treatment in routine psychiatric care: patient characteristics and insomnia-depression comorbidity

Martin Kraepelien et al.

Summary: This study aimed to compare comorbidity and patient characteristics before and after the implementation of CBT-I for patients receiving treatment for depression. While pretreatment symptom levels were high, there were no significant changes in insomnia severity or comorbid diagnosis after CBT-I implementation. Contrary to expectations, comorbid depression levels among insomnia patients having CBT-I remained similar to previous studies.

JOURNAL OF SLEEP RESEARCH (2022)

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Article Clinical Neurology

The effect of sleep restriction therapy for insomnia on sleep pressure and arousal: a randomized controlled mechanistic trial

Leonie F. Maurer et al.

Summary: The study aimed to investigate the mechanisms of action of sleep restriction therapy (SRT) on sleep pressure and arousal. The results showed that SRT increased sleep pressure and decreased arousal during acute implementation, providing support for its mechanism of action.

SLEEP (2022)

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Review Clinical Neurology

HPA axis activity in patients with chronic insomnia: A systematic review and meta of case-control studies

Raphael J. Dressle et al.

Summary: This study aimed to evaluate the differences in cortisol levels, the hormonal end product of the HPA axis, between patients with insomnia and good sleeper controls. The results suggested that patients with insomnia showed moderately increased cortisol levels, with higher effect sizes found when analyzing studies that used blood samples. There was a positive but insignificant association between the extent of objective sleep loss in insomnia patients and group differences in cortisol levels.

SLEEP MEDICINE REVIEWS (2022)

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Article Psychology, Developmental

Associations of sleep with psychological problems and well-being in adolescence: causality or common genetic predispositions?

Marije C. M. Vermeulen et al.

Summary: Short and problematic sleep are associated with worse psychological functioning in adolescents, and there are bidirectional associations between sleep and psychological problems. Changes in sleep problems in one individual of an identical twin pair are linked to increases in internalizing and externalizing problems, highlighting the importance of focusing on sleep quality for prevention and intervention.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2021)

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Review Physiology

BRAINMECHANISMS OF INSOMNIA: NEW PERSPECTIVES ON CAUSES AND CONSEQUENCES

Eus J. W. Van Someren

Summary: Insomnia is the second most common mental disorder, yet progress in understanding its underlying neurobiological mechanisms has been limited. This review explores the definition, prevalence, and susceptibility factors of insomnia, including genetic variants, early life stress, major life events, and brain structure and function. The proposed model suggests that in individuals vulnerable to developing insomnia, the locus coeruleus may be more sensitive to salience network input, leading to a spiral of hyperarousal and impaired sleep.

PHYSIOLOGICAL REVIEWS (2021)

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Article Psychology, Clinical

A Randomized Controlled Trial of the Transdiagnostic Intervention for Sleep and Circadian Dysfunction (TranS-C) to Improve Serious Mental Illness Outcomes in a Community Setting

Allison G. Harvey et al.

Summary: The study showed that TranS-C intervention significantly improved patients' functional impairment, psychiatric symptoms, and sleep and circadian functioning, with effects maintained in the long-term follow-up. This treatment also had positive effects on improving sleep efficiency, reducing wake time, and enhancing sleep health composite score.

JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY (2021)

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Article Psychology, Clinical

Does adjunctive digital CBT for insomnia improve clinical outcomes in an improving access to psychological therapies service?

Richard Stott et al.

Summary: Insomnia, often neglected in mental health programmes, has been shown to have a strong connection with anxiety and depression. A digital sleep intervention based on CBT-I principles, Sleepio, was introduced alongside other mental health interventions, resulting in significant clinical benefits and improved outcomes. This approach offers a feasible and highly scalable model for enhancing mental health outcomes in clinical services.

BEHAVIOUR RESEARCH AND THERAPY (2021)

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Article Clinical Neurology

Insomnia as a mediating therapeutic target for depressive symptoms: A sub-analysis of participant data from two large randomized controlled trials of a digital sleep intervention

Alasdair L. Henry et al.

Summary: Insomnia and depression are closely related, and cognitive behavioral therapy can help improve both conditions. Digital cognitive behavioral therapy has significant effects on insomnia and depressive symptoms, showing promise as a treatment option for individuals with clinically significant depressive symptoms.

JOURNAL OF SLEEP RESEARCH (2021)

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Article Biochemistry & Molecular Biology

Conscious experiences and high-density EEG patterns predicting subjective sleep depth

Aurelie M. Stephan et al.

Summary: This study challenges the traditional notion that slow wave sleep accounts for feeling deeply asleep, revealing that subjective sleep depth is related to a neurophysiological process predominating in early NREM sleep, particularly in REM sleep. Brain activity in sleep misperceptors is more frequent and widespread, providing insights into improving subjective sleep quality research.

CURRENT BIOLOGY (2021)

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Article Clinical Neurology

The acute effects of sleep restriction therapy for insomnia on circadian timing and vigilance

Leonie F. Maurer et al.

Summary: Sleep-restriction therapy (SRT) has been shown to improve insomnia symptoms by restricting sleep opportunity and delaying the timing of sleep attempt, leading to an increase in phase angle. Additionally, SRT has effects on psychomotor vigilance, delaying reaction time and increasing the number of lapses.

JOURNAL OF SLEEP RESEARCH (2021)

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Review Clinical Neurology

Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment

Jack D. Edinger et al.

Summary: This systematic review provides evidence on behavioral and psychological treatments for chronic insomnia disorder in adults, evaluating the clinical effects and impacts on patients.

JOURNAL OF CLINICAL SLEEP MEDICINE (2021)

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Article Clinical Neurology

Behavioral and psychological treatments for chronic insomnia disorder in adults: an American Academy of Sleep Medicine clinical practice guideline

Jack D. Edinger et al.

Summary: This guideline provides clinical practice recommendations for the use of behavioral and psychological treatments for chronic insomnia disorder in adults. It includes recommendations for using multicomponent cognitive behavioral therapy and various brief therapies in the treatment of chronic insomnia disorder.

JOURNAL OF CLINICAL SLEEP MEDICINE (2021)

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Review Clinical Neurology

The effects of non-invasive brain stimulation on sleep disturbances among different neurological and neuropsychiatric conditions: A systematic review

Alberto Herrero Babiloni et al.

Summary: Sleep disturbances and poor sleep quality are major health concerns in various neurological and neuropsychiatric clinical conditions. Repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) have the potential to improve insomnia symptoms and sleep disturbances across different types of diseases, although more research is needed to reduce bias and optimize brain stimulation parameters.

SLEEP MEDICINE REVIEWS (2021)

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Article Multidisciplinary Sciences

Insomnia subtypes characterised by objective sleep duration and NREM spectral power and the effect of acute sleep restriction: an exploratory analysis

Chien-Hui Kao et al.

Summary: Insomnia disorder is a heterogeneous condition with proposed subtypes based on objective sleep duration. This study identified three insomnia subtypes with different sleep durations and NREM spectral power, and found that acute sleep restriction improved multiple objective sleep measures across all insomnia subtypes.

SCIENTIFIC REPORTS (2021)

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Article Psychology, Multidisciplinary

Self-Conscious Affect Is Modulated by Rapid Eye Movement Sleep but Not by Targeted Memory Reactivation-A Pilot Study

Risto Halonen et al.

Summary: The quality of rapid eye movement sleep (REMS) as well as individual vulnerability toward the stressor type may affect the potential of REMS in affective processing.

FRONTIERS IN PSYCHOLOGY (2021)

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Article Clinical Neurology

Mode of delivery of Cognitive Behavioral Therapy for Insomnia: a randomized controlled non-inferiority trial of digital and face-to-face therapy

Havard Kallestad et al.

Summary: The study found that digital cognitive behavioral therapy (dCBT-I) performed significantly worse than individual face-to-face CBT-I in reducing insomnia severity, with results being inconclusive regarding the possible inferiority or non-inferiority. More clinical research is needed to clarify the optimal application of dCBT-I.

SLEEP (2021)

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Article Clinical Neurology

Event-related potentials in insomnia reflect altered perception of sleep

Bernd Feige et al.

Summary: The study found a reduced P2 amplitude in insomnia patients during phasic REM sleep, which was correlated with sleep misperception. Independent component analysis showed that frontal negativity played a key role in this group difference.

SLEEP (2021)

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Review Clinical Neurology

The clinical effects of sleep restriction therapy for insomnia: A meta-analysis of randomised controlled trials

Leonie F. Maurer et al.

Summary: Sleep restriction therapy effectively improves insomnia severity and sleep continuity in the short term, with potential comparable efficacy to multicomponent cognitive-behavioural therapy; further studies are needed to assess long-term effects and effectiveness in clinical practice.

SLEEP MEDICINE REVIEWS (2021)

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Article Clinical Neurology

Cost-effectiveness of digital cognitive behavioral therapy (Sleepio) for insomnia: a Markov simulation model in the United States

Michael Darden et al.

Summary: The study found that fully automated digital cognitive behavioral therapy (CBT) is the most cost-effective treatment for insomnia in the United States, followed by group CBT, pharmacotherapy, and individual CBT. Utilizing automated digital CBT to treat insomnia at a population scale is financially prudent and beneficial from a societal perspective.

SLEEP (2021)

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Article Clinical Neurology

Mode of delivery of Cognitive Behavioral Therapy for Insomnia: a randomized controlled non-inferiority trial of digital and face-to-face therapy

Havard Kallestad et al.

Summary: The study found that digital cognitive behavioral therapy for insomnia (dCBT-I) is comparable to individual face-to-face (FtF) CBT-I in reducing insomnia severity. However, dCBT-I performed worse than FtF CBT-I at both week 33 and week 9. More clinical research is needed to clarify the optimal application, dissemination, and implementation of dCBT-I.

SLEEP (2021)

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Review Neurosciences

Sleep, insomnia, and depression

Dieter Riemann et al.

NEUROPSYCHOPHARMACOLOGY (2020)

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Letter Psychiatry

Combined Internet-Based Cognitive-Behavioral and Chronobiological Intervention for Insomnia: A Randomized Controlled Trial

Kim Dekker et al.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2020)

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Article Clinical Neurology

The European Academy for Cognitive Behavioural Therapy for Insomnia: An initiative of the European Insomnia Network to promote implementation and dissemination of treatment

Chiara Baglioni et al.

JOURNAL OF SLEEP RESEARCH (2020)

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Article Clinical Neurology

Long-term benefits of digital cognitive behavioural therapy for insomnia: Follow-up report from a randomized clinical trial

Annemarie I. Luik et al.

JOURNAL OF SLEEP RESEARCH (2020)

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Article Clinical Neurology

Network outcome analysis identifies difficulty initiating sleep as a primary target for prevention of depression: a 6-year prospective study

Tessa F. Blanken et al.

SLEEP (2020)

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Article Clinical Neurology

The effects of digital cognitive behavioral therapy for insomnia on cognitive function: a randomized controlled trial

Simon D. Kyle et al.

SLEEP (2020)

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Article Medicine, General & Internal

Primary care treatment of insomnia: study protocol for a pragmatic, multicentre, randomised controlled trial comparing nurse-delivered sleep restriction therapy to sleep hygiene (the HABIT trial)

Simon D. Kyle et al.

BMJ OPEN (2020)

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Article Clinical Neurology

Isolating the role of me in bed restriction in the treatment of insomnia: a randomized, controlled, dismantling trial comparing sleep restriction therapy with time in bed regularization

Leonie Franziska Maurer et al.

SLEEP (2020)

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Article Psychiatry

Effectiveness of Sequential Psychological and Medication Therapies for Insomnia Disorder: A Randomized Clinical Trial

Charles M. Morin et al.

JAMA PSYCHIATRY (2020)

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Review Engineering, Biomedical

Profile of Somryst Prescription Digital Therapeutic for Chronic Insomnia: Overview of Safety and Efficacy

Charles M. Morin

EXPERT REVIEW OF MEDICAL DEVICES (2020)

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Article Clinical Neurology

Efficacy of digital cognitive behavioural therapy for insomnia: a meta-analysis of randomised controlled trials

Hui Ling Soh et al.

SLEEP MEDICINE (2020)

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Review Psychology, Clinical

The efficacy of cognitive and behavior therapies for insomnia on daytime symptoms: A systematic review and network meta-analysis

Fee Benz et al.

CLINICAL PSYCHOLOGY REVIEW (2020)

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Article Psychiatry

Digital Cognitive Behavioral Therapy for Insomnia for Adolescents With Mental Health Problems: Feasibility Open Trial

Bethany Cliffe et al.

JMIR MENTAL HEALTH (2020)

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Article Clinical Neurology

REM sleep fragmentation associated with depressive symptoms and genetic risk for depression in a community-based sample of adolescents

Anu-Katriina Pesonen et al.

JOURNAL OF AFFECTIVE DISORDERS (2019)

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Article Genetics & Heredity

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

Philip R. Jansen et al.

NATURE GENETICS (2019)

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Article Genetics & Heredity

Biological and clinical insights from genetics of insomnia symptoms

Jacqueline M. Lane et al.

NATURE GENETICS (2019)

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Review Clinical Neurology

The effect of non-pharmacological sleep interventions on depression symptoms: A meta-analysis of randomised controlled trials

Brioney Gee et al.

SLEEP MEDICINE REVIEWS (2019)

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Review Clinical Neurology

Insomnia as a predictor of mental disorders: A systematic review and meta-analysis

Elisabeth Hertenstein et al.

SLEEP MEDICINE REVIEWS (2019)

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Article Clinical Neurology

Haunted by the past: old emotions remain salient in insomnia disorder

Rick Wassing et al.

BRAIN (2019)

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Article Biochemistry & Molecular Biology

Restless REM Sleep Impedes Overnight Amygdala Adaptation

Rick Wassing et al.

CURRENT BIOLOGY (2019)

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Article Clinical Neurology

British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: An update

Sue Wilson et al.

JOURNAL OF PSYCHOPHARMACOLOGY (2019)

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Article Clinical Neurology

Depression prevention via digital cognitive behavioral therapy for insomnia: a randomized controlled trial

Philip Cheng et al.

SLEEP (2019)

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Article Neurosciences

Data-Driven Analysis of EEG Reveals Concomitant Superficial Sleep During Deep Sleep in Insomnia Disorder

Julie Anja Engelhard Christensen et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Article Psychiatry

Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial

Colin A. Espie et al.

JAMA PSYCHIATRY (2019)

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Article Multidisciplinary Sciences

Accurate whole-night sleep monitoring with dry-contact ear-EEG

Kaare B. Mikkelsen et al.

SCIENTIFIC REPORTS (2019)

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Article Clinical Neurology

Long-Term Effects of an Unguided Online Cognitive Behavioral Therapy for Chronic Insomnia

Oystein Vedaa et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2019)

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Editorial Material Clinical Neurology

The Value of Digital Insomnia Therapeutics: What We Know and What We Need To Know

Emerson M. Wickwire

JOURNAL OF CLINICAL SLEEP MEDICINE (2019)

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Review Clinical Neurology

Orexin receptor antagonists for the treatment of insomnia and potential treatment of other neuropsychiatric indications

W. Joseph Herring et al.

JOURNAL OF SLEEP RESEARCH (2019)

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Letter Psychiatry

Introducing Network Intervention Analysis to Investigate Sequential, Symptom-Specific Treatment Effects: A Demonstration in Co-Occurring Insomnia and Depression

Tessa F. Blanken et al.

PSYCHOTHERAPY AND PSYCHOSOMATICS (2019)

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Article Clinical Neurology

Overnight worsening of emotional distress indicates maladaptive sleep in insomnia

Rick Wassing et al.

SLEEP (2019)

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Review Clinical Neurology

Cognitive behavioral therapy for insomnia: A meta-analysis of long-term effects in controlled studies

Tanja van der Zweerde et al.

SLEEP MEDICINE REVIEWS (2019)

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Article Psychiatry

Insomnia disorder subtypes derived from life history and traits of affect and personality

Tessa F. Blanken et al.

LANCET PSYCHIATRY (2019)

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Article Oncology

Internet-Delivered Cognitive-Behavioral Therapy for Insomnia in Breast Cancer Survivors: A Randomized Controlled Trial

Robert Zachariae et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Clinical Neurology

Insomnia-perchance a dream? Results from a NREM/REM sleep awakening study in good sleepers and patients with insomnia

Bernd Feige et al.

SLEEP (2018)

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Review Clinical Neurology

A lack of consistent brain alterations in insomnia disorder: An activation likelihood estimation meta-analysis

Masoud Tahmasian et al.

SLEEP MEDICINE REVIEWS (2018)

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Review Clinical Neurology

A meta-analysis of associations between obesity and insomnia diagnosis and symptoms

Wai Sze Chan et al.

SLEEP MEDICINE REVIEWS (2018)

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Article Oncology

Internet-Delivered Cognitive-Behavioral Therapy for Insomnia in Breast Cancer Survivors: A Randomized Controlled Trial

Robert Zachariae et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2018)

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Article Clinical Neurology

Insomnia-perchance a dream? Results from a NREM/REM sleep awakening study in good sleepers and patients with insomnia

Bernd Feige et al.

SLEEP (2018)

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Review Clinical Neurology

How does sleep restriction therapy for insomnia work? A systematic review of mechanistic evidence and the introduction of the Triple-R model

Leonie F. Maurer et al.

SLEEP MEDICINE REVIEWS (2018)

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Article Psychiatry

Insomnia Really Hurts: Effect of a Bad Night's Sleep on Pain Increases With Insomnia Severity

Yishul Wei et al.

FRONTIERS IN PSYCHIATRY (2018)

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Article Psychiatry

EEG Microstates Indicate Heightened Somatic Awareness in Insomnia: Toward Objective Assessment of Subjective Mental Content

Yishul Wei et al.

FRONTIERS IN PSYCHIATRY (2018)

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Article Clinical Neurology

European guideline for the diagnosis and treatment of insomnia

Dieter Riemann et al.

JOURNAL OF SLEEP RESEARCH (2017)

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Article Genetics & Heredity

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

Anke R. Hammerschlag et al.

NATURE GENETICS (2017)

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Article Clinical Neurology

Three-Year Follow-Up Comparing Cognitive Behavioral Therapy for Depression to Cognitive Behavioral Therapy for Insomnia, for Patients With Both Diagnoses

Kerstin Blom et al.

SLEEP (2017)

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Article Clinical Neurology

Investigating psychological and physiological responses to the Trier Social Stress Test in young adults with insomnia

Ivy Y. Chen et al.

SLEEP MEDICINE (2017)

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Article Clinical Neurology

Sleep and cognitive performance: cross-sectional associations in the UK Biobank

Simon D. Kyle et al.

SLEEP MEDICINE (2017)

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Review Clinical Neurology

Heart rate variability in insomnia patients: A critical review of the literature

Kirsty L. Dodds et al.

SLEEP MEDICINE REVIEWS (2017)

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Review Clinical Neurology

Sleep and emotion regulation: An organizing, integrative review

Cara A. Palmer et al.

SLEEP MEDICINE REVIEWS (2017)

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Article Psychiatry

Effect of a Web-Based Cognitive Behavior Therapy for Insomnia Intervention With 1-Year Follow-up A Randomized Clinical Trial

Lee M. Ritterband et al.

JAMA PSYCHIATRY (2017)

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Article Clinical Neurology

Three-Year Follow-Up Comparing Cognitive Behavioral Therapy for Depression to Cognitive Behavioral Therapy for Insomnia, for Patients With Both Diagnoses

Kerstin Blom et al.

SLEEP (2017)

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Article Multidisciplinary Sciences

Insomnia with objective short sleep duration is associated with longer duration of insomnia in the Freiburg Insomnia Cohort compared to insomnia with normal sleep duration, but not with hypertension

Anna F. Johann et al.

PLOS ONE (2017)

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Article Clinical Neurology

S3-Guideline Non-restorative Sleep/Sleep Disorders Chapter Insomnia in Adults (AWMF-Registration Number 063-003), Update 2016

D. Riemann et al.

SOMNOLOGIE (2017)

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Article Psychiatry

The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis

Daniel Freeman et al.

LANCET PSYCHIATRY (2017)

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Article Neurosciences

Insomnia and Personality-A Network Approach

Kim Dekker et al.

BRAIN SCIENCES (2017)

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Review Clinical Neurology

The Cost of Insomnia and the Benefit of Increased Access to Evidence-Based Treatment Cognitive Behavioral Therapy for Insomnia

Sarah A. Reynolds et al.

SLEEP MEDICINE CLINICS (2017)

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Article Psychology, Clinical

Treating Depression and Anxiety with Digital Cognitive Behavioural Therapy for Insomnia: A Real World NHS Evaluation Using Standardized Outcome Measures

Annemarie I. Luik et al.

BEHAVIOURAL AND COGNITIVE PSYCHOTHERAPY (2017)

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Review Medicine, General & Internal

Psychological and Behavioral Interventions for Managing Insomnia Disorder: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians

Michelle Brasure et al.

ANNALS OF INTERNAL MEDICINE (2016)

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Editorial Material Medicine, General & Internal

Cognitive Behavioral Therapy for Chronic Insomnia: Confronting the Challenges to Implementation

Roger G. Kathol et al.

ANNALS OF INTERNAL MEDICINE (2016)

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Review Medicine, General & Internal

Pharmacologic Treatment of Insomnia Disorder: An Evidence Report for a Clinical Practice Guideline by the American College of Physicians

Timothy J. Wilt et al.

ANNALS OF INTERNAL MEDICINE (2016)

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Article Medicine, General & Internal

Management of Chronic Insomnia Disorder in Adults: A Clinical Practice Guideline From the American College of Physicians

Amir Qaseem et al.

ANNALS OF INTERNAL MEDICINE (2016)

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Article Multidisciplinary Sciences

Internet-Delivered Cognitive Behavioral Therapy to Treat Insomnia: A Systematic Review and Meta-Analysis

Michael Seyffert et al.

PLOS ONE (2016)

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Article Multidisciplinary Sciences

Slow dissolving of emotional distress contributes to hyperarousal

Rick Wassing et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

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Article Psychology

Sleep and Mental Disorders: A Meta-Analysis of Polysomnographic Research

Chiara Baglioni et al.

PSYCHOLOGICAL BULLETIN (2016)

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Article Clinical Neurology

Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia

Michele A. Colombo et al.

SLEEP (2016)

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Article Clinical Neurology

I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia

Yishul Wei et al.

SLEEP (2016)

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Article Clinical Neurology

Guided Online or Face-to-Face Cognitive Behavioral Treatment for Insomnia: A Randomized Wait-List Controlled Trial

Jaap Lancee et al.

SLEEP (2016)

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Article Clinical Neurology

Cost-Effectiveness of Group and Internet Cognitive Behavioral Therapy for Insomnia in Adolescents: Results from a Randomized Controlled Trial

Eduard J. De Bruin et al.

SLEEP (2016)

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Review Clinical Neurology

Efficacy of internet-delivered cognitive-behavioral therapy for insomnia - A systematic review and meta-analysis of randomized controlled trials

Robert Zachariae et al.

SLEEP MEDICINE REVIEWS (2016)

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Review Clinical Neurology

Sleep disturbances compared to traditional risk factors for diabetes development: Systematic review and meta-analysis

Thunyarat Anothaisintawee et al.

SLEEP MEDICINE REVIEWS (2016)

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Article Physiology

More Severe Insomnia Complaints in People with Stronger Long-Range Temporal Correlations in Wake Resting-State EEG

Michele A. Colombo et al.

FRONTIERS IN PHYSIOLOGY (2016)

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Article Clinical Neurology

Wake High-Density Electroencephalographic Spatiospectral Signatures of Insomnia

Michele A. Colombo et al.

SLEEP (2016)

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Article Clinical Neurology

I Keep a Close Watch on This Heart of Mine: Increased Interoception in Insomnia

Yishul Wei et al.

SLEEP (2016)

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Article Clinical Neurology

Guided Online or Face-to-Face Cognitive Behavioral Treatment for Insomnia: A Randomized Wait-List Controlled Trial

Jaap Lancee et al.

SLEEP (2016)

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Article Clinical Neurology

Cost-Effectiveness of Group and Internet Cognitive Behavioral Therapy for Insomnia in Adolescents: Results from a Randomized Controlled Trial

Eduard J. De Bruin et al.

SLEEP (2016)

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Article Psychiatry

Effectiveness of an online insomnia program (SHUTi) for prevention of depressive episodes (the GoodNight Study): a randomised controlled trial

Helen Christensen et al.

LANCET PSYCHIATRY (2016)

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Review Clinical Neurology

The neurobiology, investigation, and treatment of chronic insomnia

Dieter Riemann et al.

LANCET NEUROLOGY (2015)

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Article Clinical Neurology

The Nature of Stable Insomnia Phenotypes

Vivek Pillai et al.

SLEEP (2015)

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Review Clinical Neurology

Towards standardisation and improved understanding of sleep restriction therapy for insomnia disorder: A systematic examination of CBT-I trial content

Simon D. Kyle et al.

SLEEP MEDICINE REVIEWS (2015)

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Article Medicine, General & Internal

Insomnia disorder

Charles M. Morin et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

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Article Clinical Neurology

The Nature of Stable Insomnia Phenotypes

Vivek Pillai et al.

SLEEP (2015)

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Article Multidisciplinary Sciences

Unobtrusive ambulatory EEG using a smartphone and flexible printed electrodes around the ear

Stefan Debener et al.

SCIENTIFIC REPORTS (2015)

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Review Psychology, Clinical

Sleep-related attentional bias in insomnia: A state-of-the-science review

Kamelia Harris et al.

CLINICAL PSYCHOLOGY REVIEW (2015)

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Article Psychology, Clinical

Guided internet cognitive behavioral therapy for insomnia compared to a control treatment - A randomized trial

Viktor Kaldo et al.

BEHAVIOUR RESEARCH AND THERAPY (2015)

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Article Psychology, Clinical

Internet-vs. group-delivered cognitive behavior therapy for insomnia: A randomized controlled non-inferiority trial

Kerstin Blom et al.

BEHAVIOUR RESEARCH AND THERAPY (2015)

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Article Psychology, Clinical

The Role of Sleep in Emotional Brain Function

Andrea N. Goldstein et al.

ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 10 (2014)

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Review Psychiatry

Sleep in infancy and childhood: implications for emotional and behavioral difficulties in adolescence and beyond

Avi Sadeh et al.

CURRENT OPINION IN PSYCHIATRY (2014)

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Letter Cardiac & Cardiovascular Systems

Insomnia and risk of cardiovascular disease: A meta-analysis of cohort studies

Min Li et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2014)

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Editorial Material Cell Biology

UK Biobank Data: Come and Get It

Naomi E. Allen et al.

SCIENCE TRANSLATIONAL MEDICINE (2014)

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Article Clinical Neurology

Insomnia Disorder is Associated with Increased Amygdala Reactivity to Insomnia-Related Stimuli

Chiara Baglioni et al.

SLEEP (2014)

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Article Clinical Neurology

Stress and Sleep Reactivity: A Prospective Investigation of the Stress-Diathesis Model of Insomnia

Christopher L. Drake et al.

SLEEP (2014)

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Review Clinical Neurology

The genetics of insomnia - Evidence for epigenetic mechanisms?

Laura Palagini et al.

SLEEP MEDICINE REVIEWS (2014)

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Review Clinical Neurology

Sleep changes. in the disorder of insomnia: A meta-analysis of polysomnographic studies

Chiara Baglioni et al.

SLEEP MEDICINE REVIEWS (2014)

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Article Medicine, General & Internal

The Sleep Condition Indicator: a clinical screening tool to evaluate insomnia disorder

Colin A. Espie et al.

BMJ OPEN (2014)

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Article Psychology, Biological

The microstructure of sleep in primary insomnia: An overview and extension

Bernd Feige et al.

INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY (2013)

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Article Clinical Neurology

Stepped Care for Insomnia: an Evaluation of Implementation in Routine Practice

Norah Vincent et al.

JOURNAL OF CLINICAL SLEEP MEDICINE (2013)

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Review Clinical Neurology

Insomnia with objective short sleep duration: The most biologically severe phenotype of the disorder

Alexandros N. Vgontzas et al.

SLEEP MEDICINE REVIEWS (2013)

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Article Clinical Neurology

Use of the Internet and Mobile Media for Delivery of Cognitive Behavioral Insomnia Therapy

Colin A. Espie et al.

SLEEP MEDICINE CLINICS (2013)

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Article Psychology, Biological

Increased EEG sigma and beta power during NREM sleep in primary insomnia

Kai Spiegelhalder et al.

BIOLOGICAL PSYCHOLOGY (2012)

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Article Psychiatry

Meta-Analysis of Sleep Disturbance and Suicidal Thoughts and Behaviors

Wilfred R. Pigeon et al.

JOURNAL OF CLINICAL PSYCHIATRY (2012)

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Article Clinical Neurology

Insomnia Pharmacotherapy

Timothy Roehrs et al.

NEUROTHERAPEUTICS (2012)

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Review Pharmacology & Pharmacy

REM Sleep Instability - A New Pathway for Insomnia?

D. Riemann et al.

PHARMACOPSYCHIATRY (2012)

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Article Clinical Neurology

The Consensus Sleep Diary: Standardizing Prospective Sleep Self-Monitoring

Colleen E. Carney et al.

SLEEP (2012)

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Article Clinical Neurology

A Randomized, Placebo-Controlled Trial of Online Cognitive Behavioral Therapy for Chronic Insomnia Disorder Delivered via an Automated Media-Rich Web Application

Colin A. Espie et al.

SLEEP (2012)

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Review Clinical Neurology

Acute insomnia: Current conceptualizations and future directions

Jason G. Ellis et al.

SLEEP MEDICINE REVIEWS (2012)

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Article Psychiatry

Testing the Reliability and Validity of DSM-IV-TR and ICSD-2 Insomnia Diagnoses Results of a Multitrait-Multimethod Analysis

Jack D. Edinger et al.

ARCHIVES OF GENERAL PSYCHIATRY (2011)

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Review Clinical Neurology

Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies

Chiara Baglioni et al.

JOURNAL OF AFFECTIVE DISORDERS (2011)

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Review Pharmacology & Pharmacy

Chronic Insomnia: Clinical and Research Challenges - An Agenda

D. Riemann et al.

PHARMACOPSYCHIATRY (2011)

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Review Clinical Neurology

Histamine in the regulation of wakefulness

Mahesh M. Thakkar

SLEEP MEDICINE REVIEWS (2011)

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Article Psychology, Clinical

Sleep disturbance as transdiagnostic: Consideration of neurobiological mechanisms

Allison G. Harvey et al.

CLINICAL PSYCHOLOGY REVIEW (2011)

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Review Clinical Neurology

The hyperarousal model of insomnia: A review of the concept and its evidence

Dieter Riemann et al.

SLEEP MEDICINE REVIEWS (2010)

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Review Clinical Neurology

The role of personality traits in insomnia

Merijn van de Laar et al.

SLEEP MEDICINE REVIEWS (2010)

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Editorial Material Psychology, Applied

Sleep, Self-Regulation, Self-Control and Health

Martin S. Hagger

STRESS AND HEALTH (2010)

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Article Psychology, Clinical

Psychophysiological reactivity to sleep-related emotional stimuli in primary insomnia

Chiara Baglioni et al.

BEHAVIOUR RESEARCH AND THERAPY (2010)

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Article Psychiatry

The epidemiology of insomnia: Associations with physical and mental health. The HUNT-2 study

Borge Sivertsen et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2009)

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Article Clinical Neurology

Stepped Care: A Health Technology Solution for Delivering Cognitive Behavioral Therapy as a First Line Inysomnia Treatment

Colin A. Espie

SLEEP (2009)

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Review Medical Laboratory Technology

Genomic and personalized medicine: foundations and applications

Geoffrey S. Ginsburg et al.

TRANSLATIONAL RESEARCH (2009)

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Article Clinical Neurology

Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients

Bernd Feige et al.

JOURNAL OF SLEEP RESEARCH (2008)

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Article Clinical Neurology

Sleep and affect in older adults: using multilevel modeling to examine daily associations

Christina S. Mccrae et al.

JOURNAL OF SLEEP RESEARCH (2008)

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Article Clinical Neurology

A comparison of insomnia and depression as predictors of disability pension: The HUNT Study

Simon Overland et al.

SLEEP (2008)

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Article Clinical Neurology

Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia

Rachel Manber et al.

SLEEP (2008)

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Article Clinical Neurology

Dysfunctional beliefs and attitudes about sleep (DBAS):: Validation of a brief version (DBAS-16)

Charles M. Morin et al.

SLEEP (2007)

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Article Business

Insomnia, emotions, and job satisfaction: A multilevel study

Brent A. Scott et al.

JOURNAL OF MANAGEMENT (2006)

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Review Clinical Neurology

The attention-intention-effort pathway in the development of psychophysiologic insomnia: A theoretical review

Colin A. Espie et al.

SLEEP MEDICINE REVIEWS (2006)

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Review Clinical Neurology

Recommendations for a standard research assessment of insomnia

Daniel J. Buysse et al.

SLEEP (2006)

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Article Neurosciences

Homeostatic, circadian, and emotional regulation of sleep

CB Saper et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2005)

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Review Multidisciplinary Sciences

Hypothalamic regulation of sleep and circadian rhythms

CB Saper et al.

NATURE (2005)

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Review Clinical Neurology

Practice parameters for the indications for polysomnography and related procedures: An update for 2005

CA Kushida et al.

SLEEP (2005)

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Review Clinical Neurology

Cognitive behaviour therapy for primary insomnia: Can we rest yet?

AG Harvey et al.

SLEEP MEDICINE REVIEWS (2003)

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Review Psychology, Clinical

A cognitive model of insomnia

AG Harvey

BEHAVIOUR RESEARCH AND THERAPY (2002)

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Review Clinical Neurology

Epidemiology of insomnia: what we know and what we still need to learn

MM Ohayon

SLEEP MEDICINE REVIEWS (2002)

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Article Clinical Neurology

Beta/Gamma EEG activity in patients with primary and secondary insomnia and good sleeper controls

ML Perlis et al.

SLEEP (2001)

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