期刊
JOURNAL OF ALZHEIMERS DISEASE
卷 52, 期 4, 页码 1321-1333出版社
IOS PRESS
DOI: 10.3233/JAD-160038
关键词
Alzheimer's disease; cerebrospinal fluid; frontotemporal dementia; Lewy body disease; microRNAs; mild cognitive impairment
资金
- Center for Translational Molecular Medicine [02N-101]
- EU Joint Programme Neurodegenerative Disease Research (JPND) through The Netherlands (ZonMw)
- EU Joint Programme Neurodegenerative Disease Research (JPND) through Italy (Finanziamento Ministero Salute)
- Ministry of University and Research [2010WPJXK]
- University of Antwerp Research Fund
- Alzheimer Research Foundation (SAO-FRA)
- Agency for Innovation by Science and Technology (IWT)
- Research Foundation Flanders (FWO)
- Belgian Science PolicyOffice Interuniversity Attraction Poles (IAP) program (BELSPO)
- Flemish Government initiated Methusalem excellence grant (EWI)
- Flanders Impulse Program on Networks for Dementia Research (VIND)
- EU/EFPIA Innovative Medicines Initiative Joint Undertaking (EMIF) [115372]
MicroRNAs (miRNAs) regulate translational inhibition of proteins, but are also detected in body fluids, including cerebrospinal fluid (CSF), where they may serve as disease-specific biomarkers. Previously, we showed differential expression of miR-146a, miR-29a, and miR-125b in the CSF of Alzheimer's disease (AD) patients versus controls. In this study, we aim to confirm these findings by using larger, independent sample cohorts of AD patients and controls from three different centers. Furthermore, we aim to identify confounding factors that possibly arise using such a multicenter approach. The study was extended by including patients diagnosed with mild cognitive impairment due to AD, frontotemporal dementia and dementia with Lewy bodies. Previous results of decreased miR-146a levels in AD patients compared to controls were confirmed in one center. When samples from all three centers were combined, several confounding factors were identified. After controlling for these factors, we did not identify differences in miRNA levels between the different groups. However, we provide suggestions to circumvent various pitfalls when measuring miRNAs in CSF to improve future studies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据