期刊
JOURNAL OF PSYCHOSOMATIC RESEARCH
卷 155, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychores.2022.110743
关键词
Obsessive-compulsive disorder; Pediatrics; Inflammation; Cytokines; Saliva; Biomarkers; Child; Adolescent; Inflammation mediators
类别
资金
- BC Childrens Hospital Research Institute
- International OCD Foundation Young Investigator Award
- Canadian Institutes of Health Research
- Michael Smith Foundation for Health Research
- BC Mental Health and Substance Use Services Research Institute
This study compared the salivary defense proteins and inflammatory mediators in children and youth with childhood-onset OCD and healthy controls. The results showed that pro-inflammatory cytokines were associated with the diagnosis and severity of OCD.
Objective: Childhood-onset obsessive-compulsive disorder (OCD) has been associated with immune dysregulation, including aberrant plasma inflammatory markers and increased rates of infectious and immune-mediated disorders. Saliva may provide a minimally-invasive tool for assessing oral mucosal immunity and inflammatory biomarkers in this population. The primary aim of this study was to compare salivary defense proteins and inflammatory mediators in saliva from children and youth with OCD and healthy controls, and evaluate their associations with measures of oral health and OCD phenotype. Methods: In this cross-sectional observational study, saliva was collected from 41 children and youth with childhood-onset OCD and 46 healthy controls. Levels of lysozyme, alpha-amylase, secretory immunoglobulin A (sIgA), C-reactive protein (CRP), interleukin-6 (IL-6), IL-1 beta, and tumor necrosis factor-alpha (TNF-alpha) were quantified by enzyme-linked immunosorbent assays or electrochemiluminescent-based immunoassays. Results: All analytes were detectable in saliva. When adjusting for salivary flow rate and total protein, multiple linear regression models including demographic variables, oral health measures, and OCD status explained a significant proportion of the variance in IL-6, IL-1 beta, and sIgA but not TNF-alpha, CRP, alpha-amylase, or lysozyme levels. Diagnosis of OCD was associated with significantly higher IL-6 (beta = 0.403, p = 0.026), while severity of OCD was a significant predictor of increased cytokines (IL-6,beta = 0.325, p = 0.009; IL-1 beta,beta = 0.284, p = 0.020; TNF-alpha, beta = 0.269, p = 0.036), but not other analytes. Conclusion: These data point to the feasibility of analyzing soluble immune mediators in the saliva in childhood onset OCD, suggesting that pro-inflammatory cytokines are associated with OCD diagnosis and symptom severity. Further work is required to elucidate the factors contributing to this association and implications for clinical practice.
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