期刊
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
卷 47, 期 2, 页码 E86-E98出版社
CMA-CANADIAN MEDICAL ASSOC
DOI: 10.1503/jpn.210121
关键词
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资金
- National Natural Science Foundation of China [81761128021, 81771452]
- National Institute of Health [R01MH112180]
- Estonian Research Council-European Union Regional Developmental Fund Mobilitas Pluss Program [MOBTT77]
- Beijing Municipal Administration of Hospitals Incubating Program [PX2021074]
This study investigated the role of the cytokine TGF-beta 1 in patients with schizophrenia and found that higher levels of TGF-beta 1 were associated with abnormalities in brain structure and cognitive function.
Background: Evidence indicates that cytokines are associated with cognitive deficits in schizophrenia; however, the underlying brain-behaviour mechanisms remain unclear. We hypothesized that aberrations in brain structural connectivity mediate the cytokine effect in schizophrenia. Methods: In this study, we recruited patients with first-episode schizophrenia (n = 75, average illness duration 12.3 months, average medication period 0.6 days) and healthy controls (n = 44) of both sexes. We first conducted whole-blood RNA sequencing to detect differentially expressed genes. We also explored transcriptomic data on the dorsal lateral prefrontal cortices (dIPFC) retrieved from the CommonMind Consortium for gene functional clustering; we measured plasma transforming growth factor 1.11 (TGF-beta 1) levels by enzyme-linked immunosorbent assay; we acquired high-resolution T,-weighted MRI data on cortical thickness MRI; and we assessed cognitive function using the validated Chinese version of the MATRICS Consensus Cognitive Battery. We compared these parameters in patients with schizophrenia and controls, and analyzed their associations. Results: Patients with schizophrenia had higher TGF-beta 1 at both the mRNA level (log(2) fold change = 0.24; adjusted p = 0.026) and the protein level (12.85 +/- 6.01 mu g/mL v. 8.46 +/- 5.15 mu g/mL, adjusted p < 0.001) compared to controls. Genes coexpressed with TGFB1 in the dlPFC were less abundant in patients with schizophrenia compared to healthy controls. In patients with schizophrenia, TGF-beta 1 protein levels were inversely correlated with cortical thickness, especially of the lateral occipital cortex (r = -0.47, adjusted p = 0.001), and with the MATRICS Consensus Cognitive Battery visual learning and memory domain (r = -0.50, adjusted p < 0.001). We found a complete mediation effect of the thickness of the lateral occipital cortex on the negative relationship between TGF-beta 1 and visual cognition (p < 0.05). Limitations: We did not explore the effect of other blood cytokines on neurocognitive performance and cortical thickness. Participants from the CommonMind Consortium did not all have first-episode schizophrenia and they were not all antipsychotic-naive, so we could not exclude an effect of antipsychotics on TGF-beta 1 signalling in the dIPFC. The sample size and cross-sectional design of our study were additional limitations. Conclusion: These findings highlighted an association between upregulated blood levels of TGF-beta 1 and impairments in brain structure and function in schizophrenia.
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