Preparation of Magadiite-Sodium Alginate Drug Carrier Composite by Pickering-Emulsion-Templated-Encapsulation Method and Its Properties of Sustained Release Mechanism by Baker-Lonsdale and Korsmeyer-Peppas Model

In this study, the nanohybrid drug carrier were synthesized by Pickering emulsion-templated encapsulation (PETE) method to control the sustained-released properties of the nanohybrid drug carrier; magadiite-cetyltriphenyl phosphonium bromide (MAG-CTPB-KH550) and sodium alginate (NaC6H7O6) was dissolved in the aqueous phase but metronidazole (C6H9N3O3) was dissolved in the ethyl acetate (CH3COOC2H5) of the oil phase; both the oil phase and the aqueous phase were mixed and dispersed to prepared organically-modified magadiite-sodium alginate (MAG-CTPB-KH550/SA) nanohybrid drug carrier. X-ray diffraction (XRD), Flourier transform infrared spectrometry (FTIR) and scanning electron microscopy (SEM) results were shown that the most of Sodium alginate (SA) were encapsulated into the MAG-CTPB-KH550 but a few of SA were intercalated into the inner space layers of MAG-CTPB-KH550, metronidazole was combined with carrier materials through physical apparent adsorption, ion exchange and electrostatic interaction. In vitro result, it was showed that the slow release was shown less than 10% content of Sodium alginate; whereas, it was reduced the initial release percentage of Metronidazole but it was extended the sustained-released time. To reach at equilibrium, the sustained-released effects of the drug carrier were prepared with 10% of Sodium Alginate for 32 h and the maximum cumulative release percentage was 93.42% for 24 h. First order model, Baker-Lonsdale model and Korsmeyer-Peppas model were fitted to study the slow-release mechanism; the correlation coefficients (R-2) of the three models were found over 0.9; thus, it was well described the release kinetics behavior of drug carrier composites. The slow-release mechanisms of the drug carrier were performed swelling and dissolving but the barrier effects of the lamina that were reduced the dissolution percentage of metronidazole. [GRAPHICS] .

Automated summary

In this study, a nanohybrid drug carrier was synthesized using the PETE method and its sustained-release properties were controlled. The results of XRD, FTIR, and SEM analysis showed that the carrier successfully encapsulated sodium alginate and metronidazole, and the slow-release mechanism was explained.